A5021055736- Telomeres, Telomerase, and Senescence
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Neuroblastoma Research and Treatments
- Cardiac Ischemia and Reperfusion
- S100 Proteins and Annexins
- Sirtuins and Resveratrol in Medicine
- DNA Repair Mechanisms
- Neuroscience and Neuropharmacology Research
- Protein Kinase Regulation and GTPase Signaling
- Breast Cancer Treatment Studies
- Cancer Mechanisms and Therapy
- Brain Metastases and Treatment
- MicroRNA in disease regulation
- Hereditary Neurological Disorders
- Corneal Surgery and Treatments
- Organ Donation and Transplantation
- Head and Neck Surgical Oncology
- Ocular Oncology and Treatments
- Neuroendocrine Tumor Research Advances
- Helicobacter pylori-related gastroenterology studies
- Circadian rhythm and melatonin
- Metabolism, Diabetes, and Cancer
- Neurofibromatosis and Schwannoma Cases
Chongqing University
2025
University of California, Irvine
2021-2024
University of California, Irvine Medical Center
2024
Duke University
2018-2019
University of Hong Kong
2011
Capital Medical University
2005
Intravitreal injection of antisense oligonucleotides targeting mutated Ataxin-7 improves visual function in a mouse model spinocerebellar ataxia type 7.
Spinocerebellar ataxia type 7 (SCA7) is a retinal-cerebellar degenerative disorder caused by CAG-polyglutamine (polyQ) repeat expansions in the ataxin-7 gene. As many SCA7 clinical phenotypes occur mitochondrial disorders, and magnetic resonance spectroscopy of patients revealed altered energy metabolism, we considered role for dysfunction. Studies mice uncovered marked impairments oxygen consumption respiratory exchange. When examined cerebellar Purkinje cells mice, observed network...
Telomerase can promote neuron survival and be regulated by growth factors such as brain-derived neurotrophic factor (BDNF). Increases of BDNF expression telomerase activity after brain injury suggest that may involved in BDNF-mediated neuroprotection. We investigated regulation rat spinal cord motor neurons (SMNs). Our results indicate increases levels SMNs activates mitogen-activated protein kinase/extracellular signal-regulated kinases 1 2 phosphatidylinositol-3-OH kinase/protein kinase B...
Osteoporosis (OP) is a progressive metabolic bone disease characterized by impaired microarchitecture, decreased strength, and dysregulated remodeling, leading to an increased risk of fractures. Among osteoporotic fractures, vertebral compression fractures (OVCF) are the most common can significantly impact patients' quality life. Growing evidence suggests that microRNAs (miRNAs) play crucial role in homeostasis regulating osteoblast differentiation, metabolism, remodeling processes....
The authors have no relevant conflicts of interest to disclose.
In the most cases, invasive ductal carcinoma (IDC) of breast is identifiable when they present with classic infiltrative growth pattern. However, subset IDC can occur in a very sneaky way, significantly mimicking appearance situ (DCIS). this condition, it’s much easier to miss component without pulling ancillary staining morphologic findings are extremely compatible DCIS, especially diagnosis DCIS was made on previous biopsy. Here, we reported 55 year-old female who noted have...
Abstract Introduction/Objective Malignant peripheral nerve sheath tumors (MPNST) most commonly affect the proximal extremities and paraspinal region. Primary hepatic MPNST is extremely rare. Here we report a primary with heterologous glandular differentiation in patient Neurofibromatosis type 1 (NF1). Methods/Case Report Review of clinical features histopathological findings resected specimen. A review all published cases liver MPNST. Results (if Case Study enter NA) 69-year-old male history...