A5016612175- Microbial metabolism and enzyme function
- Angiogenesis and VEGF in Cancer
- Kruppel-like factors research
- Advanced Surface Polishing Techniques
- Cell Adhesion Molecules Research
- Russia and Soviet political economy
- TGF-β signaling in diseases
- Industrial Vision Systems and Defect Detection
- Bone and Dental Protein Studies
- Economic and Technological Developments in Russia
- Cancer Genomics and Diagnostics
- Caveolin-1 and cellular processes
- Genetic factors in colorectal cancer
- Aortic aneurysm repair treatments
- Advancements in Photolithography Techniques
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tissue Engineering and Regenerative Medicine
- Economic, Social, and Public Health Issues in Russia and Globally
- Lung Cancer Treatments and Mutations
North-Caucasus Federal University
2021
University Health Network
2015-2019
Princess Margaret Cancer Centre
2015-2019
University of Toronto
2018
Petrozavodsk State University
2018
Integrin α11β1 is a stromal cell-specific receptor for fibrillar collagens and overexpressed in carcinoma-associated fibroblasts (CAFs). We have investigated its direct role cancer progression by generating severe combined immune deficient (SCID) mice integrin α11 (α11) expression. The growth of A549 lung adenocarcinoma cells two patient-derived non-small cell carcinoma (NSCLC) xenografts these knockout (α11−/−) was significantly impeded, as compared with wild-type (α11+/+) SCID mice....
Integrin α11, a stromal collagen receptor, promotes tumor growth and metastasis of non-small cell lung cancer (NSCLC) is associated with the regulation stiffness in stroma. We have previously reported that lysyl oxidase like-1 (LOXL1), matrix cross-linking enzyme, down-regulated integrin α11-deficient mice. In present study, we investigated relationship between LOXL1 role NSCLC tumorigenicity. Our results show expression α11 was correlated three adenocarcinoma patient datasets indeed...
Carcinoma-associated fibroblasts (CAFs) are abundant stromal cells in tumor microenvironment that critically involved cancer progression. Contrasting reports have shown CAFs can either pro- or antitumorigenic roles, indicating functionally heterogeneous. Therefore, to precisely target the cancer-promoting CAF subsets, it is necessary identify specific markers define these subpopulations and understand their functions. We characterized two subsets from 28 non–small cell lung (NSCLC) patient...
ABSTRACT Background Genomic profiling of patient tumors has linked somatic driver mutations to survival outcomes non-small cell lung cancer (NSCLC) patients, especially for those receiving targeted therapies. However, it remains unclear whether specific non-driver have any prognostic utility. Methods Whole exomes and transcriptomes were measured from NSCLC xenograft models patients with diverse clinical outcomes. Penalised regression analysis was performed identify a set 865 genes associated...