A5044304794- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- interferon and immune responses
- Computational Drug Discovery Methods
- Dyeing and Modifying Textile Fibers
- Cell death mechanisms and regulation
- Photonic Crystals and Applications
- Silk-based biomaterials and applications
- NF-κB Signaling Pathways
Mario Negri Institute for Pharmacological Research
2023-2024
National Research Council
2023
Institute of Organic Synthesis and Photoreactivity
2019
Abstract Alzheimer’s disease (AD), the leading cause of dementia in older adults, is a double proteinopathy characterized by amyloid-β (Aβ) and tau pathology. Despite enormous efforts that have been spent last decades to find effective therapies, late pharmacological interventions along course disease, inaccurate clinical methodologies enrollment patients, inadequate biomarkers for evaluating drug efficacy not allowed development an therapeutic strategy. The approaches followed so far...
Abstract This work describes the preparation of a novel substrate based on keratin extracted from wool and its application as potential support for solution‐processed organic solar cells. Optically transparent, free‐standing, resistant films are successfully prepared, starting water solution, characterized in terms morphology, structure, thermal mechanical properties. The effect solvents annealing is also investigated order to mimic evaluate impact processing conditions used devices...
Inhibitor of Apoptosis Proteins (IAPs) are validated targets for cancer therapy, and the deregulation their activities within NF-κB pathway correlates with chemoresistance events, even after treatment IAPs-antagonists in clinic (Smac-mimetics). The molecule FC2 was identified as a modulator MDA-MB-231 adenocarcinoma cells virtual screening Chembridge library against Baculoviral IAP Repeat 1 (BIR1) domain cIAP2 XIAP. An improved cytotoxic effect is observed when combined Smac-mimetics or...