A5049727157- Connexins and lens biology
- Bacillus and Francisella bacterial research
- Heat shock proteins research
- Orthopaedic implants and arthroplasty
- Photoreceptor and optogenetics research
- RNA Interference and Gene Delivery
- Social Media in Health Education
- Impact of Technology on Adolescents
- Hip and Femur Fractures
- Bone fractures and treatments
- Health Literacy and Information Accessibility
University of Chicago
2022-2024
Cleveland Clinic Lerner College of Medicine
2015-2019
Cleveland Clinic
2018
Highlights•Cx46-mediated cell-cell communication is essential for GBM self-renewal•A communication-based screening platform identifies clofazimine as a Cx46 inhibitor•Clofazimine targets CSCs and has little effect on non-stem tumor cells•Clofazimine treatment of tumor-bearing mice extends survival in vivoSummaryGap-junction-mediated enables cells to synchronize complex processes. We previously found that glioblastoma cancer stem (CSCs) express higher levels the gap junction protein compared...
// Maksim Sinyuk 1,2 , Alvaro G. Alvarado 1,3 Pavel Nesmiyanov 4 Jeremy Shaw 1 Erin E. Mulkearns-Hubert Jennifer T. Eurich James S. Hale Anna Bogdanova Masahiro Hitomi Jaroslaw Maciejewski 3,5,6 Alex Y. Huang 6,7 Yogen Saunthararajah and Justin D. Lathia 1,2,3,6 Department of Cellular Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA 2 Biological, Geological, Environmental Sciences, State University, 3 College Case Western Immunology Allergy, Volgograd...
Recently social media use within healthcare has increased significantly. Today, it is common for patients to browse the Internet, including physicians' pages, learn about their medical conditions and search providers. The purpose of this study analyze among hand surgeons, compare between academic private surgeons.Using American Society Surgery Hand's (ASSH) online directory, all active members practicing ten most populated U.S. cities were identified. Social presence was determined by an...
https://ota.org/education/ota-online-resources/video-library-procedures-techniques/achievinglimb-length-equality.
Summary Gap junction-mediated cell-cell communication enables tumor cells to synchronize the execution of complex processes. Despite connexin family gap junction proteins being considered suppressors, we previously found that glioblastoma cancer stem (CSCs) express higher levels Cx46 compared non-stem cells, and this was necessary sufficient for CSC maintenance. To develop a targeting strategy, utilized point mutants disrupt specific functions coupling critical function CSCs. Based on...
Gap junction-mediated cell-cell communication enables tumor cells to synchronize the execution of complex processes. Despite connexin family gap junction proteins being considered suppressors, we previously found that glioblastoma cancer stem (CSCs) express higher levels Cx46 compared non-stem cells, and this was necessary sufficient for CSC maintenance. To develop a targeting strategy, utilized point mutants disrupt specific functions coupling critical function CSCs. Based on finding,...