A5018542682- Trace Elements in Health
- Metal complexes synthesis and properties
- Lanthanide and Transition Metal Complexes
- Molecular Sensors and Ion Detection
- Drug Transport and Resistance Mechanisms
- Magnetism in coordination complexes
- Nanoparticle-Based Drug Delivery
- Advanced MRI Techniques and Applications
- Electrochemical Analysis and Applications
- Advanced NMR Techniques and Applications
- Heavy Metal Exposure and Toxicity
- Neuroscience and Neuropharmacology Research
The University of Texas at Dallas
2018-2024
It has been demonstrated that divalent zinc ions packaged with insulin in β-cell granules can be detected by MRI during glucose-stimulated secretion using a gadolinium-based Zn2+-sensitive agent. This study was designed to evaluate whether simpler agent design having single Zn2+-sensing moieties but variable Zn2+ binding affinities might also detect from the pancreas. Using an implanted MR-compatible window hold pancreas fixed position for imaging, we now demonstrate focally intense "hot...
The design, synthesis, and properties of a new gadolinium-based copper-responsive magnetic resonance imaging (MRI) contrast agent is presented. sensor (GdL1) has high selectivity for copper ions exhibits 43% increase in r1 relaxivity (20 MHz) upon binding to 1 equiv Cu2+ aqueous buffer. Interestingly, the presence physiological levels human serum albumin (HSA), amplified further up 270%. Additional spectroscopic X-ray absorption spectroscopy (XAS) studies show that coordinated by two...
A Mn(II)-based zinc-sensitive MRI contrast agent, MnPyC3A-BPEN, was prepared, characterized, and applied in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas prostate
This study was designed to test whether the single appended phosphonate group in GdDOTA-1AmP is sufficient for catalyzing exchange of proton from inner-sphere water-exchanging molecule. Unlike other derivatives this series, showed a surprisingly smooth increase r1 relaxivity 3.0 6.3 mM–1 s–1 at 20 MHz as pH lowered 9 2.5. In comparison bis-, tris-, and tetrakis-phosphonate analogues, which all show biphasic dependence with changes pH, unique versus characteristics are shown closely parallel...
<div> <p>The design, synthesis, and properties of a new gadolinium-based copper-responsive MRI contrast agents are presented in detail here. The sensor (GdL<sub>1</sub>) has high selectivity for copper ions exhibits 47% increase r<sub>1</sub> relaxivity upon binding to 1 equivalent Cu<sup>2+</sup> aqueous buffer. Interestingly, the presence physiological levels human serum albumin (HSA), is amplified even further up 270%. Additional...
The design, synthesis, and properties of a new gadolinium-based copper-responsive MRI contrast agents are presented in detail here. sensor (GdL 1 ) has high selectivity for copper ions exhibits 47% increase r relaxivity upon binding to equivalent Cu 2+ aqueous buffer. Interestingly, the presence physiological levels human serum albumin (HSA), is amplified even further up 270%. Additional spectroscopic XAS studies show that coordinated by two carboxylic acid groups single amine group on an...
A Mn(II)-based zinc-sensitive MRI contrast agent, Mn(PyC3A)-BPEN, was prepared and characterized the agent used in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from mouse pancreas prostate <i>in vivo</i>. Thermodynamic kinetic stability tests showed that Mn(PyC3A-BPEN) has superior inertness compared Gd(DTPA), is less susceptible transmetallation presence of excess Zn<sup>2+</sup> ions, transchelation by albumin. In comparison with other...
A Mn(II)-based zinc-sensitive MRI contrast agent, Mn(PyC3A)-BPEN, was prepared and characterized the agent used in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from mouse pancreas prostate vivo . Thermodynamic kinetic stability tests showed that Mn(PyC3A-BPEN) has superior inertness compared Gd(DTPA), is less susceptible transmetallation presence of excess Zn 2+ ions, transchelation by albumin. In comparison with other gadolinium-based sensors bearing a single...