A5035231209- RNA modifications and cancer
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- Click Chemistry and Applications
- Digestive system and related health
- Biotin and Related Studies
- Genetics and Neurodevelopmental Disorders
- Neurogenetic and Muscular Disorders Research
- Data Analysis with R
- interferon and immune responses
- Advanced Biosensing Techniques and Applications
University of California, Los Angeles
2017-2020
The Robertson Trust
2008
mathematical models, discussing the interpretation of PK parameters.Compartment models and distribution drug concentration throughout body are discussed in Chapter 5 6 briefly introduces pharmaco-dynamics (PD), study effect drugs, PK-PD modelling, relating to potency toxicity.A real example from AstraZeneca is used illustrate some methods, good use made synthetic examples explain concepts.There a dearth references, which makes further reading difficult text appear be very personal view...
Little is known about the role of epithelial membrane protein-2 (EMP2) in breast cancer development or progression. In this study, we tested hypothesis that EMP2 may regulate formation self-renewal stem cells (BCSC) tumor microenvironment.
Abstract Cancer immuno-editing is a process that describes the interaction between immune cells and tumor cells. This can result in elimination of developing tumor, dormancy, or are capable surviving an immune-competent host. We have recently uncovered novel mechanism immunoediting by tetraspan protein Epithelial membrane EMP2. propose EMP2 serves as bridge innate adaptive immunity via mediated type I interferon expression. Most evade system through suppression ignorance. levels promote...
<div>Abstract<p>Little is known about the role of epithelial membrane protein-2 (EMP2) in breast cancer development or progression. In this study, we tested hypothesis that EMP2 may regulate formation self-renewal stem cells (BCSC) tumor microenvironment. <i>In silico</i> analysis gene expression data demonstrated a correlation with metastasis-related genes and markers (CSC) including aldehyde dehydrogenase (ALDH). cell lines, overexpression increased knockdown...
<p>Anti-EMP2 mAbs reduce tumor load in two trials using MDA-MB-231 xenograft models.</p>
<p>Modulation of EMP2 produces transcriptomic changes in breast cancer.</p>
<div>Abstract<p>Little is known about the role of epithelial membrane protein-2 (EMP2) in breast cancer development or progression. In this study, we tested hypothesis that EMP2 may regulate formation self-renewal stem cells (BCSC) tumor microenvironment. <i>In silico</i> analysis gene expression data demonstrated a correlation with metastasis-related genes and markers (CSC) including aldehyde dehydrogenase (ALDH). cell lines, overexpression increased knockdown...
<p>Modulation of EMP2 produces transcriptomic changes in breast cancer.</p>
<p>EMP2 and ALDH1 staining in breast cancer</p>
<p>EMP2 and ALDH1 staining in breast cancer</p>
<p>Anti-EMP2 mAbs reduce tumor load in two trials using MDA-MB-231 xenograft models.</p>
<p>Supplemental Methods</p>
<p>Tumorsphere formation of breast cancer cells with modified EMP2 levels</p>
<p>Secondary tumor formation following anti-EMP2 therapy.</p>
<p>Selected functional pathways affected by changes in EMP2 expression.</p>
<p>Characteristics of 23 mammary and breast cancer cell lines.</p>
<p>Selected functional pathways enriched with EMP2 mRNA based on TCGA data.</p>
<p>Supplemental Methods</p>
<p>Characteristics of 23 mammary and breast cancer cell lines.</p>
<p>Tumorsphere formation of breast cancer cells with modified EMP2 levels</p>
<p>Selected functional pathways affected by changes in EMP2 expression.</p>
<p>Selected functional pathways enriched with EMP2 mRNA based on TCGA data.</p>
<p>Secondary tumor formation following anti-EMP2 therapy.</p>
Abstract The rapid advances in sequencing, genomics and bioinformatics have generated a huge amount of genomic data available at our disposal. However, some proteins, the products those genes, are expressed cells or tissues extremely low levels, making identification characterization proteins bottle neck for biomedical research field. Approximately, 65% human proteome is less than few thousand copies. Thus, availability protein detection probes tools becomes critical element to measure lower...