A5022632835- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Inflammatory Myopathies and Dermatomyositis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Viral Infections and Immunology Research
- Smoking Behavior and Cessation
- High Altitude and Hypoxia
- Phagocytosis and Immune Regulation
- SARS-CoV-2 and COVID-19 Research
- Complement system in diseases
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- Sarcoidosis and Beryllium Toxicity Research
- Bipolar Disorder and Treatment
- Nicotinic Acetylcholine Receptors Study
- Dietary Effects on Health
- Pancreatitis Pathology and Treatment
- Genetic Neurodegenerative Diseases
- Tryptophan and brain disorders
- Peptidase Inhibition and Analysis
Instituto Nacional de Enfermedades Respiratorias
2018-2025
Universidad Nacional Autónoma de México
2023
Interferons (IFNs) are a group of cytokines with antiviral, antiproliferative, antiangiogenic, and immunomodulatory activities. Type I IFNs amplify propagate the antiviral response by interacting their receptors, IFNAR1 IFNAR2. In COVID-19, IFNAR2 (interferon alpha beta receptor subunit 2) gene has been associated severity disease, but soluble (sIFNAR2) levels have not investigated. We aimed to evaluate association variants (rs2236757, rs1051393, rs3153, rs2834158, rs2229207) COVID-19...
Background . The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement genetic factors. There are scarce data available on classical HLA class I association with pandemic. Methods We analyzed frequency alleles and haplotypes in case-control study including 138 patients (INF-P) 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. typing was performed by high-resolution sequence-based method. Results Our analysis revealed...
Abstract Background The impact of genetic variants in the expression tumor necrosis factor-α (TNF-α) and its receptors coronavirus disease 2019 (COVID-19) severity has not been previously explored. We evaluated association TNF (rs1800629 rs361525), TNFRSF1A (rs767455 rs1800693), TNFRSF1B (rs1061622 rs3397) with COVID-19 severity, assessed as invasive mechanical ventilation (IMV) requirement, plasma levels soluble TNF-α, TNFR1, TNFR2 patients severe COVID-19. Methods study included 1353...
Around 50% of rheumatoid arthritis (RA) patients show some extra-articular manifestation, with the lung a usually affected organ; in addition, presence anti-citrullinated protein antibodies (ACPA) is common feature, which caused by citrullination modifications, catalyzed peptidyl arginine deiminases (PAD) enzymes. We aimed to identify single nucleotide variants (SNV) PADI2 and PADI4 genes (PAD2 PAD4 proteins, respectively) associated susceptibility interstitial disease (ILD) RA PAD2 levels....
Genetic variants related to susceptibility chronic respiratory conditions such as interstitial lung disease (ILD) could share critical pathways in the pathogenesis of COVID-19 and be implicated outcomes post-COVID-19. We aimed identify participation genetic function ILD genes severe post-COVID-19 condition. studied 936 hospitalized patients with COVID-19. The requirement invasive mechanical ventilation (IMV) acute distress syndrome (ARDS) classification were considered. mortality was...
An impaired coagulation process has been described in patients with severe or critical coronavirus disease (COVID-19). Nevertheless, the implication of coagulation-related genes not explored. We aimed to evaluate impact F5 rs6025 and SERPINE1 rs6092 on invasive mechanical ventilation (IMV) requirement levels proteins among COVID-19. Four-hundred fifty-five COVID-19 were genotyped using TaqMan assays. Coagulation-related (P-Selectin, D-dimer, P-selectin glycoprotein ligand-1, tissue...
In COVID-19, critical disease and invasive mechanical ventilation (IMV) increase the risk of death, mainly in patients over 60 years age.To find relationship between miR-21-5p miR-146a-5p terms severity, IMV, mortality hospitalized COVID-19 younger than 55 age.The were stratified according to severity using IDSA/WHO criteria for severe subclassified into non-survivors survivors.Ninety-seven severe/critical included; 81.3% deceased male 18.8% female. Higher expression levels associated as...
Background: Genetic association studies have identified single nucleotide polymorphisms (SNPs) related to COPD susceptibility. Aim: identify HHIP genetic variants associated with COPD, pulmonary function, and serum sputum protein levels in Mexican mestizo smokers. Material methods: Association analysis was performed by carrying out a case-control study smokers comprising two groups: tobacco-smoking subjects (COPD-TS, n = 222) without (SWOC, 333). We evaluated three SNPs (rs13147758,...
The pathogenesis of Rheumatoid Arthritis (RA) is not fully understood, probably influenced by genetic and environmental factors. Interstitial Lung Disease (ILD) an extra-articular manifestation RA, which contributes significantly to morbidity mortality. identification anti-HLA antibodies has been useful in the transplantation field; however, its contribution autoimmune diseases as RA studied. We aimed determine presence patients with without ILD possible association clinical biochemical...
The antisynthetase syndrome (ASSD) is an autoimmune disorder characterized by myositis, arthritis, mechanic's hands, fever, Raynaud phenomenon, and interstitial lung disease (ILD). We aimed to evaluate single-nucleotide polymorphisms in the interleukin 1B ( IL1B ) gene their association between ILD with autoantibodies, as well IL-1β serum levels. most frequent autoantibody was anti-Jo1. tomographic pattern non-specific pneumonia, whereas anti-Jo1 subjects, it organized pneumonia. Anti-Jo1...
This paper assesses the association of insertion/deletion ACE (angiotensin-converting enzyme) variant (rs1799752 I/D) and serum activity with severity COVID-19 as well its impact on post-COVID-19, we compare these associations those for patients non-COVID-19 respiratory disorders. We studied 1252 COVID-19, 104 subjects recovered from 74 hospitalized a disease different COVID-19. The rs1799752 was assessed using TaqMan® Assays. determined colorimetric assay. DD genotype related to risk...
: The presence of the rs35705950 variant in
Supplemental oxygen (SO) increases survival in hypoxemic patients. In hypoxia, mammals respond by modulating O2-sensitive transducers that stabilize the transcription factor hypoxia-inducible factor-1-alpha (HIF-1α), which transactivates genes govern angiogenesis and metabolic pathways. Residing at high altitudes exposes millions of people to hypoxemia with potential adverse consequences on their health. We aimed identify markers can be used evaluation patients addition pulse oximetry...
Protein citrullination is accomplished by a broad enzyme family named Peptidyl Arginine Deiminases (PADs), which makes this post-translational modification in many proteins that perform physiological and pathologic mechanisms the body. Due to these modifications, has become significant topic study of pathological processes. It been related some chronic autoimmune diseases, including rheumatoid arthritis (RA), interstitial lung diseases (ILD), multiple sclerosis (MS), certain types cancer,...
Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by joint inflammation. It presents extra-articular manifestations, with the lungs being one of affected areas. Among these, damage to pulmonary interstitium (Interstitial Lung Disease—ILD) has been linked proteins involved in inflammatory process and related extracellular matrix deposition lung fibrosis establishment. Peptidyl arginine deiminase enzymes (PAD), which carry out protein citrullination, play a role this...
Tobacco smoking is the leading risk factor for many respiratory diseases. Several genes are associated with nicotine addiction, such as CHRNA5 and ADAM33. This research aims to evaluate association of polymorphisms rs16969968 (CHRNA5) rs3918396 (ADAM33) in patients who developed severe COVID-19. We included 917 COVID-19 hospitalized critical disease oxygenation impairment. They were divided into two groups, tobacco-smoking (n = 257) non-smoker 660) patients. The genotype allele frequencies...
Antisynthetase syndrome (ASSD) is a rare multisystemic connective tissue disease affecting the skin, joints, muscles, and lungs, characterized by anti-aminoacyl transfer-RNA-synthetases (anti-tRNA) autoantibodies production, being anti-Jo1 most frequent. We included one-hundred twenty-one ASSD patients 340 healthy subjects (HS), also, we divided case group into non-anti-Jo1. Two single nucleotide polymorphisms (SNPs) in IL17A gene were evaluated. Anti-Jo1 was common anti-tRNA antibody our...
<b>Introduction:</b> Tobacco smoking is the leading risk factor for many respiratory diseases, and current smokers have an increased of a worst clinical COVID-19 outcome. Several genes are associated with nicotine addiction. This research aimed to evaluate association polymorphisms rs16969968 (CHRNA5) y rs3918396 (ADAM33) in patients who developed severe COVID-19. <b>Methods:</b> We included 917 hospitalized critical disease oxygenation impairment. They were divided into two groups,...
Critical disease status and invasive mechanical ventilation (IMV) increase the risk of death in COVID-19. The miR-21-5p miR-146a-5p are involved with molecules participating severe forms We aimed to find relationship between miRNAs, severity, IMV, mortality under 55 years hospitalized patients. Patients were stratified according severity IDSA/WHO criteria as critical subclassified into non-survivors survivors. Ninety-seven severe/critical COVID-19 patients (median 43 years) included. 81.3%...
<b>Introduction:</b> Tobacco smoking is a complex and multifactorial disease involving both environmental genetic factors. In Mexican mestizo population, single-nucleotide polymorphisms (SNP) associated with cigarette greater degree of nicotine addiction have been identified; however, no possible roles explored the age initiation smoking, nor in success quitting smoking. <b>Methods:</b> present study 151 smokers were included, grouped according to at which they started (table 1), those who...