A5033197027- Saffron Plant Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Adipokines, Inflammation, and Metabolic Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chemotherapy-induced cardiotoxicity and mitigation
- Liver physiology and pathology
- Inflammasome and immune disorders
- Natural Antidiabetic Agents Studies
- Chemotherapy-induced organ toxicity mitigation
- Liver Disease Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Vitamin C and Antioxidants Research
- Nephrotoxicity and Medicinal Plants
- Chronic Myeloid Leukemia Treatments
- Cancer Mechanisms and Therapy
- Pregnancy and Medication Impact
- Garlic and Onion Studies
- Pancreatic function and diabetes
- Immune Response and Inflammation
- Medicinal Plants and Bioactive Compounds
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Phytochemical and Pharmacological Studies
Mansoura University
2013-2023
Zagazig University
2016
Isra University
2005
Rutgers New Jersey Medical School
1993
Rutgers, The State University of New Jersey
1993
Cooper Institute
1977
Ulcerative colitis (UC) is usually a mildly active disease; however, it can be associated with serious systemic complications. The current study was undertaken to evaluate the anti-ulcerogenic and coloprotective properties of crocin; major biologically ingredient saffron against experimentally-induced UC, by intracolonic instillation AA (AA). Rats received either felodipine (3 mg/kg) or crocin (20 orally for 8 successive days as protective curative therapies. Either remedy, significantly...
The fish oil-derived omega-3 fatty acids, like docosahexanoic (DHA), claim a plethora of health benefits. We currently evaluated the antitumor effects DHA, alone or in combination with cisplatin (CP) EAC solid tumor mice model, and monitored concomitant changes serum levels C-reactive protein (CRP), lipid peroxidation (measured as malondialdehyde; MDA) leukocytic count (LC). Further, we verified capacity DHA to ameliorate lethal, CP-induced nephrotoxicity rats molecular mechanisms involved...
The aim of this study was to evaluate and compare the effects imatinib nilotinib that silymarin on established liver fibrosis oxidative stress in a thioacetamide (TAA) rat model. Male Wistar rats received intraperitoneal (i.p.) injections TAA (150mg/kg, twice weekly) for 12weeks. Daily treatments with (10mg/kg), (100mg/kg) were administered orally during last 4weeks TAA-administration. At end study, hepatic damage evaluated by analysis function tests serum. Hepatic histopathology collagen...
Epigallocatechin-gallate (EGCG) and resveratrol (RSVL) are two of the most promising natural medicines. We verified their capacity to ameliorate cisplatin (CP)-induced disruption renal glomerular filtration rate (GFR) in rats, sought mediatory involvement lipid peroxidation (malondialdehyde [MDA]-level) inflammatory cytokine (TNF-α) therein. CP (10 mg kg−1), a single i.p. dose, disrupted GFR (11-fold-rise proteinuria, 2–5-fold rise serum creatinine/urea levels) after 7 days, killed all...
Diabetic nephropathy [DN] is one of the most prevalent microvascular complications diabetes mellitus [DM] and it considered a leading cause kidney failure. In this study calycosin, an isoflavone that constitutes major constituent in Radix Astragali with numerous pharmacological merits was investigated as reno-protective agent against DN also potential underlying mechanisms were investigated. Streptozotocin (STZ) (40 mg/kg) injected peritoneal cavity male Sprague-Dawely rats to induce DM. For...
Breast cancer prevalence has been globally increasing, therefore, introducing novel interventions in treatment is of a significant importance. The present study was designed to investigate the anti-cancer effect Canagliflozin (CNG) an experimental model DMBA-induced mammary carcinoma female rats.18 rats were divided into three groups: Normal control, DMBA DMBA+ CNG treated group. (7.5 mg/kg) injected subcutaneously cells twice weekly for 4 weeks and (10 orally administered daily additional 3...
The present study was designed to explore the possible protective effects of agmatine, a known nitric oxide (NO) synthase inhibitor, against gentamicin-induced nephrotoxicity in rats. For this purpose, we quantitatively evaluated renal structural and functional alterations using histopathological biochemical approaches. Furthermore, effect agmatine on hypersensitivity urinary bladder rings acetylcholine (ACh) evaluated. Twenty-four male Wistar albino rats were randomly divided into 3 groups,...
Pulmonary fibrosis is a progressive fatal lung disorder with significantly high mortality rates. Bleomycin (BLM) one of the most commonly used chemotherapeutic agents for treatment several carcinomas. The severe adverse effect BLM pulmonary toxicity; therefore, has been repeatedly reported to be considered amongst widely induction experimental fibrosis. In current study, flavocoxid investigated its ability ameliorate BLM-induced was instilled intratracheally and administered orally (20...
This work aimed to investigate a possible mechanism that may mediate the hepatoprotective effects of pomegranate fruit extract (PFE) against thioacetamide (THIO)-induced liver fibrosis in rats. Male Sprague Dawley rats were randomly allocated into four groups (n = 8 each): control; PFE (150 mg/kg/day, orally); THIO (200 mg/kg, i.p, 3 times week); and PFE-treated groups. Oral treatment decreased liver/body weight ratio by 12.4%, diminished serum function levels ALT, AST, ALP, LDH, total...