A5001549639- Signaling Pathways in Disease
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Genetics, Aging, and Longevity in Model Organisms
- RNA Interference and Gene Delivery
- NF-κB Signaling Pathways
- Advanced biosensing and bioanalysis techniques
- Telomeres, Telomerase, and Senescence
- Advanced Nanomaterials in Catalysis
- Spaceflight effects on biology
- Vanadium and Halogenation Chemistry
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Metal-Catalyzed Oxygenation Mechanisms
- Autophagy in Disease and Therapy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Polyoxometalates: Synthesis and Applications
- Integrated Circuits and Semiconductor Failure Analysis
- Neurofibromatosis and Schwannoma Cases
- Biological Stains and Phytochemicals
National Cancer Institute
2022-2024
Cancer Genetics (United States)
2022-2024
Center for Cancer Research
2022-2024
Government of the United States of America
2022
Centre for DNA Fingerprinting and Diagnostics
2011-2017
Institute of Liver and Biliary Sciences
2017
Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), master regulator response, acts as a prime modifier c-MYC-mediated transcription. HSF1 deficiency diminishes DNA binding and dampens genome wide. Mechanistically, c-MYC, MAX, assemble into transcription complex on genomic DNAs, surprisingly, dispensable. Instead, physically recruits histone acetyltransferase general...
Abstract Calcineurin (CN) is a major calmodulin binding serine/threonine phosphatase which plays crucial role in numerous mammalian signal transduction pathways. inhibitors represent valuable tool for elucidating CN dependent cellular processes. The present work deals with the synthesis and comprehensive characterization of new polymer anchored peroxo niobium complex, [Nb 2 (O ) 6 (carboxylate) ]‐PA (Nb [PA=poly(sodium acrylate)], identification set comprising neat homoleptic as well...
ABSTRACT Unlike genomic instability, the implications of proteomic instability in cancer remain ambiguous. By governing proteotoxic stress response, heat shock factor 1 (HSF1) sustains stability upon environmental insults. Apart from its importance to resistance and survival, HSF1 is emerging as a powerful, generic oncogenic enabler. In Neurofibromatosis type I ( NF1 )-deficient malignant peripheral nerve sheath tumor (MPNST) cells, depletion prompted protein polyubiquitination, aggregation,...
Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remain poorly defined. Here, we show that heat shock factor 1 (HSF1), master regulator heat-shock response, acts as a prime modifier c-MYC-mediated transcription. HSF1 deficiency diminishes DNA binding and dampens genome-widely. Mechanistically, c-MYC, MAX, assemble into transcription complex on genomic DNAs and, surprisingly, dispensable. Instead, physically recruits histone...
Transcription factors (TFs) play a pivotal role in gene expression, and their DNA binding is the prerequisite to instigating transcription. Here, we present protocol that exploits proximity ligation assay technique measure DNA-binding activities of TFs situ at single-cell resolution. We describe steps for immunostaining with specific antibodies against double-stranded interest, probe incubation, ligation, signal amplification. then detail procedures imaging image analysis. For complete...
ABSTRACT Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is attuned quantitatively remain poorly defined. Here, we show that heat shock factor 1 (HSF1), master regulator heat-shock, or proteotoxic stress, response, acts as a key modifier c-MYC-mediated transcription. HSF1 deficiency diminishes DNA binding and dampens genome-widely. Mechanistically, c-MYC, MAX, assemble into transcription complex on genomic DNAs and, surprisingly, dispensable. Instead,...