A5057896433- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vasculitis and related conditions
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Inflammatory Myopathies and Dermatomyositis
- Urticaria and Related Conditions
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Pulmonary Hypertension Research and Treatments
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Vibrio bacteria research studies
- Bone and Joint Diseases
- Renal Diseases and Glomerulopathies
- Bacterial biofilms and quorum sensing
- Bone Metabolism and Diseases
- Autoimmune Bullous Skin Diseases
- Galectins and Cancer Biology
- Lipid metabolism and disorders
Marqués de Valdecilla University Hospital
2016-2025
Instituto de Investigación Marqués de Valdecilla
2015-2024
Universidad de Cantabria
2016-2022
Institute for Atherosclerosis Research
2018
Center for Rheumatology
2016
Fundación Marques de Valdecilla
2012-2013
Abstract Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk enhanced by dysregulation adipokines. Low omentin levels were associated with metabolic dysfunction and conditions different from axSpA. Accordingly, we evaluated genetic functional implication subclinical atherosclerosis a cohort 385 axSpA patients. Subclinical was carotid ultrasound. Omentin rs12409609, linkage disequilibrium polymorphism risk, genotyped patients 84 controls....
Abstract The aim of the present study was to determine if use anti‐tumor necrosis factor ( TNF )‐α monoclonal antibody adalimumab could improve endothelial function and arterial stiffness in patients with moderate severe psoriasis. This a prospective on series consecutive psoriasis who completed 6 months therapy adalimumab. Patients history cardiovascular events, diabetes mellitus, kidney disease, hypertension or body mass index 35 kg/m 2 more were excluded. Assessment by brachial artery...
The aim of this study was to determine the role endothelin-1 (ET-1), a molecule involved in multiple vascular and fibrosing abnormalities, as biomarker interstitial lung disease (ILD), well its use for differential diagnosis between idiopathic pulmonary fibrosis (IPF) ILD associated with autoimmune diseases (AD-ILD), using large well-defined cohort patients ILD. A total 112 IPF, 91 AD-ILD (28 rheumatoid arthritis (RA), 26 systemic sclerosis, 20 inflammatory myositis 17 pneumonia features) 44...
The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on this we performed first genome-wide association study (GWAS) condition. 308 IgA patients and 1,018 healthy controls from Spain were genotyped by Illumina HumanCore BeadChips. Imputation GWAS data was using 1000 Genomes Project Phase III dataset as reference panel. After quality control filters imputation, 285 1,006 remained in datasets included further analysis....
Introduction: Early diagnosis of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA) constitutes a challenge for the clinicians. Pulmonary vasculopathy is relevant in development disease. Accordingly, we aimed to explore role vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and asymmetric dimethylarginine (ADMA), key molecules vasculopathy, as potential biomarkers pulmonary fibrosis RA-ILD + . Methods: We included 21 patients two...
ABSTRACT Serratia spp. are opportunistic human pathogens responsible for an increasing number of nosocomial infections. However, little is known about the virulence factors and regulatory circuits that may enhance establishment long-term survival liquefaciens in hospital environment. In this study, two reporter strains, Chromobacterium violaceum CV026 VIR24, high-resolution triple-quadrupole liquid chromatography–mass spectrometry (LC-MS) were used to detect quantify N -acyl-homoserine...
Objective IgA vasculitis (Henoch‐Schönlein) (IgAV), formerly called Henoch‐Schönlein purpura, is the most common in children, but it not rare adults. Increased familial occurrence supports a genetic predisposition to IgAV. In this context, an association with HLA–DRB1*01 phenotype has been suggested Caucasian individuals However, data on potential of IgAV were based small case series. We undertook study further investigate by performing HLA–DRB1 genotyping largest series patients ever...
Abstract Osteoprotegerin (OPG), receptor activator of nuclear factor-ΚB ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing (TRAIL) have been involved in rheumatoid arthritis (RA) pathophysiology. In this study, we assessed messenger RNA (mRNA) expression these molecules by qPCR peripheral blood from 26 patients with RA (12 them ischemic heart disease –IHD) 10 healthy controls. Correlation coefficients between OPG, RANKL TRAIL levels their clinical demographic characteristics...
The most critical forms of coronavirus disease 2019 (COVID-19) are associated with excessive activation the inflammasome. Despite COVID-19 impact on public health, we still do not fully understand mechanisms by which inflammatory response influences prognosis. Accordingly, aimed to elucidate role polymorphisms in key genes formation and signaling inflammasome as biomarkers severity. For this purpose, a large well-defined cohort 377 patients mild (n = 72), moderate 84), severe 100), 121)...
Rheumatoid Arthritis-associated Interstitial Lung Disease (RA-ILD) significantly reduces life quality and survival, necessitating improvements in its understanding clinical management. We addressed these goals using DNA methylation analysis, which has not been done RA-ILD samples, by comparing 32 RA patients with ILD diagnosed less than one year before (cases) matched without (controls). This analysis identified 6679 differentially methylated positions (DMPs) Δβ ≥ 2% FDR < 0.05, 576 regions...
Abstract Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A SALL1 exert an influence on CRP non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes development CV RA patients. Three tag polymorphisms were genotyped 2,313 Spanish patients by TaqMan. Subclinical determined 1,298 them...
In the present study, we aimed to report our experience with rituximab (RTX) in treatment of patients ILD associated AD (AD-ILD) at a single center. For this purpose, clinical characteristics, radiological findings, and pulmonary function tests (PFTs) RTX-treated AD-ILD-patients seen from May 2016 until March 2020 referral center for individuals were retrospectively reviewed. Additionally, an updated literature review was conducted. A total 26 (mean age 58.3 ± 11.1 years diagnosis) included....
Interstitial lung disease (ILD) may occur in patients with a rheumatic autoimmune (AD), increasing their risk of morbidity and mortality. However, little is known about the prevalence AD diagnosed an ILD. In this prospective study, we determined spectrum ILD associated (AD-ILD) among sent for assessment to single clinic transplantation from referral center between May 2016 December 2019. diagnosis was made by pneumologists based on clinical radiological findings pulmonary function test...
Introduction Patients with axial spondyloarthritis (axSpA) have a high disease burden mainly due to the rheumatic itself, and also exhibit accelerated atherosclerosis, that leads higher incidence of cardiovascular (CV) disease. Accordingly, identification biomarkers CV risk inflammation in axSpA patients is clinically relevant. In this sense, given beneficial functions exerted by adipomyokine irisin processes related inflammation, our aim was assess, for first time, role as genetic...
To investigate the genetic background influencing development of cardiovascular (CV) disease in patients with rheumatoid arthritis (RA).We performed a genome-wide association study (GWAS) which, after quality control and imputation, total 6,308,944 polymorphisms across whole genome were analyzed 2,989 RA European origin. Data on subclinical atherosclerosis, obtained through assessment carotid intima-media thickness (CIMT) presence/absence plaques by ultrasonography, available for 1,355...
To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in risk of subclinical atherosclerosis patients with rheumatoid arthritis (RA).A total 576 Spanish RA from Northern Spain were genotyped for 6 well-known IL33-IL1RL1 polymorphisms (IL33 rs3939286, IL33 rs7025417, rs7044343, IL1RL1 rs2058660, rs2310173 and rs13015714) by TaqMan genotyping assay. The presence was determined assessment carotid intima-media thickness (cIMT)...