Abstract Simultaneous absence of the IgG1, IgG2, IgG4 and IgA1 immunoglobulins has been unambiguously demonstrated in a healthy 75‐year‐old woman by testing for allotypes, isoallotypes isotypes these four subclasses. Only IgM, IgD, IgG3, IgA2 IgE were present. The IgG3 levels significantly increased. Family investigation showed inheritance haplotype Gm −;−;b A2m 2 . This person is homozygous an extensive DNA deletion including Cγ1, Cγ2, Cγ4 Cα1 genes.

The first incentive leading to this study is search for the origin and nature of what Levis-Strauss meant by fundamental structures and/or hidden rules that contribute construction languages cultures within principal idea structural anthropology. This leads rethink process knowledge still a matter controversial debates. I propose DNA as physical source these innate structures. Supported evidence substantial arguments derived from latest scientific findings, suggestion developed formulated...

Background: Among polymorphisms of non-transcribed DNA sequences and functional genes, those Alu insertions that the APOE gene have been widely used to clarify degree genetic relationships between human populations.Aim: eight insertion were investigated in Tunisians compared with data from neighbour populations order gain new insights into position Tunisia Mediterranean region.Subjects methods: A total 121 individuals North Centre-South regions sampled.Results: No significant differences...

SUMMARY The Gm, Am and Km immunoglobulin allotypes ABO blood groups were studied in three of Tunisian Berbers. results showed that the actual Berbers Tunisia present certain heterogeneity their ancestors probably first inhabitants North Africa. Indeed, although Gm‐Am haplotypes are mainly Caucasoid, some them typically African. group Kesra village, most shows frequencies very close to those South European populations, particularly Spanish, who same origin. gene Berber similar recorded...

The constant region of the gamma 1, 2 and 3 heavy chains human IgG1, IgG2 IgG3 immunoglobulins carries antigenic determinants or G1m, G2m G3m allotypes, which are genetic markers these subclasses. exceptional presence on 1 Gm allotypes usually located CH3 domain shows an unexpected clustering base changes subsequent identity short DNA sequences in exon non-allelic genes. Such clusters substitutions not easily explained classical basis point mutations. A gene conversion, substituted a segment...

Abstract Aim To analyze apolipoprotein gene polymorphisms in the Tunisian population and to check relation of these homocysteine, lipid levels coronary artery disease (CAD). Methods In healthy blood donors patients with CAD complicated by myocardial infarction (MI) four [APO (a) PNR, APO E, CI CII] were determined plasma total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HLD-C) apolipoproteins (apo A-I, Apo B, E) measured. Results Analysis shows a relative genetic homogeneity...

Although much of Jordan is covered by desert, its north-western region forms part the Fertile Crescent that had given a rich past to Jordanians. This past, scarcely described historians, not yet clarified sufficient genetic data. Thus in this paper we aim determine differentiation Jordanian population and discuss origin.A total 150 unrelated healthy Jordanians were investigated for ten Alu insertion polymorphisms. Genetic relationships among populations estimated principal component (PC)...

Unusual combinations--unexpected sets, excess of lack--of antigenic determinants, or Gm allotypes, on the constant regions heavy chains human IgG1 and IgG3 immunoglobulins are accounted for in terms genetic events (exchanges, duplications deletions) involving DNA sequences, exons, coding three CH1-, CH2- CH3 domains gamma 1 3 chains. Equal unequal cross-overs at level introns without damage to CH exons postulated.

Aim: To describe the diversity of four cytochrome and sulfotransferase polymorphisms in six north African samples. Scarce data have been compiled for these samples despite rich genetic background populations. Materials & methods: CYP3A4*1B, CYP3A4*17, CYP3A4*3, CYP3A5*3, SULT1A1*2, SULT1A2*2, SULT1A2*3 SULT1E1*2 were explored 556 individuals from Morocco, Algeria, Tunisia Libya. Results: Allele frequencies our largely exceeded variation ranges described European populations, especially...

Background: The genetic differentiation of Bahrain natives is unclear because the absence adequate studies. Aim: Eight Alu insertion polymorphisms have been analysed in Bahrainis and southern Iranians to examine origins determine their position among wider Middle East populations. Subjects methods: Two representative samples 97 65 determined. Genetic relationships populations estimated by a principal component plot based on R-matrix software. Mantel tests used check statistical significance...

The Rhesus (Rh) blood group system is one of the most highly polymorphic genetic systems used in investigation human relationships. In this paper researchers aimed to expand determination Rh haplotype frequencies new samples from North African populations providing comparative analyses within and between these populations. A total 771 were collected three countries. Results reveal a general homogeneity when representative wide areas considered, regardless their current linguistic status....

It is generally accepted that the human evolutionary history was started in sub-Saharan Africa by emergence of first individuals belonging to our genus Homo. But details this evolution, particularly those its last stage relating modern man (Homo sapiens sapiens) emergence, represent until now a controversial topic. Confusion and imprecision associated with certain concepts definitions have accentuated controversy therefore helped curb progress research In paper I present these problems...

Background: It is thought that the ancient population of Libya was mainly composed Saharan Berbers. Socio-geographic conditions and historical events have exerted some changes on composition present-day Libyan population.Aim: To screen a set autosomal Alu markers in representative sample general order to study its ethnic genetic structure re-examine relationships with Mediterranean Middle Eastern groups.Subjects methods: A 190 Libyans analysed for 17 insertions. The divided according Arabic...

In recent years, several genomic regions have been robustly associated with coronary artery disease (CAD) in different genome-wide association studies (GWASs) conducted mainly people of European descent. These kinds data are lacking African populations, even though heart diseases a major cause premature death and disability.Here, 384 single nucleotide polymorphisms (SNPs) the top four CAD risk (1p13, 1q41, 9p21, 10q11) were genotyped 274 case-control samples from Morocco Tunisia, aim...

In holy Qur’an countless verses are related to topics on the nature and universe. this report I try show how these carry scientific concepts taking as examples some of those relating anthropological sciences. one God “Allah”, speaking scientists, presents signs what we designate currently coupled Cultural Biological Anthropology using eloquent terms which represent a distinct abridgement “…..variations your languages colors….”. another verse “…, Roam earth find out origin life…“ Allah urges...