A5025113251- Genetic Syndromes and Imprinting
- Kruppel-like factors research
- Epigenetics and DNA Methylation
Colgate University
2019-2021
Cancerous cells are detrimental to the human body and can be incredibly resilient against treatments because of complexities molecular carcinogenic pathways. In particular, cancer able sustain increased growth under metabolic stress due phenomena like Warburg effect. Krüppel-like factor 4 (KLF4), a context-dependent transcription that act as both tumor suppressor an oncogene, is involved in many pathways respond low glucose reactive oxygen species (ROS), raising question its role result...
Kruppel-like factor 4 (KLF4) is a zinc finger-containing transcription with diverse regulatory functions in cellular growth, proliferation, differentiation, autophagy and genomic stability. Furthermore, KLF4 exerts cell-cycle checkpoint effect part by acting as transcriptional activator of the cyclin-dependent kinase inhibitor, p21. Our lab has found that regulates autophagy, mitophagy, mitochondrial dynamics. Given close relationship these processes have metabolism, we aimed to determine...
Abstract Krüppel-like factor 4 (KLF4) is a zinc finger-containing transcription with diverse regulatory functions in cellular growth, proliferation, differentiation, autophagy and genomic stability. Furthermore, KLF4 exerts cell-cycle checkpoint effect part by acting as transcriptional activator of the cyclin-dependent kinase inhibitor, p21. Our lab has found that regulates autophagy, mitophagy, mitochondrial dynamics. Given close relationship these processes have metabolism, we aimed to...