A5101756135- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Immune cells in cancer
- Alkaloids: synthesis and pharmacology
- Pharmacological Effects of Natural Compounds
- Respiratory Support and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Acute Kidney Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Neonatal Respiratory Health Research
- Advanced Glycation End Products research
- Clinical Reasoning and Diagnostic Skills
- Clusterin in disease pathology
First Affiliated Hospital of Harbin Medical University
2017-2025
Harbin Medical University
2017-2025
Education Department of Heilongjiang Province
2025
Poor inter-rater reliability in chest radiograph interpretation has been reported the context of acute respiratory distress syndrome (ARDS), although not for Berlin definition ARDS. We sought to examine effect training material on accuracy and consistency intensivists' interpretations ARDS diagnosis. conducted a rater agreement study which 286 intensivists (residents 41.3%, junior attending physicians 35.3%, senior physician 23.4%) independently reviewed same 12 radiographs developed by...
ABSTRACT Protocatechuic acid (PCA) is a type of polyphenol with diverse biological activities, including antioxidant and anti‐inflammatory properties. This study aimed to explore the function PCA in acute respiratory distress syndrome (ARDS) delve into its functional mechanism. Lipopolysaccharides were applied stimulate human pulmonary microvascular endothelial cells (HPMECs) or C57BL/6 mice generate ARDS models vitro vivo. treatment (300 μM for 20 30 mg/kg mice) reduced proinflammatory...
ABSTRACT Sepsis is characterised by fatal organ dysfunction resulting from a dysfunctional host response to infection, imposing substantial economic burden on families and society. Therefore, identifying biomarkers for early sepsis diagnosis improving patient prognosis are critical. This study recruited 59 patients 35 healthy volunteers the Department of Critical Care Medicine at Harbin Medical University Affiliated First Hospital between March December 2021. Through combination non‐targeted...
Esculentoside A (EsA), a saponin isolated from Phytolacca esculenta, can attenuate acute liver and lung injury. However, whether EsA has protective effect against sepsis-induced kidney injury (AKI) not been reported. In this study, (2.5, 5, or 10 mg/kg) was given to rats with sepsis induced by cecal ligation puncture (CLP). We found that improved the survival of septic in dose-dependent manner. addition, lowered tubular damage score decreased blood urea nitrogen creatinine. Moreover,...
Macrophages could adhere to extracellular matrix molecules(ECM) induce the expression of pro-inflammatory mediators and phagocytosis that contribute pathogenesis pulmonary infection diseases. Fibronectin (FN) is a large glycoprotein capable interacting with various ECM molecules produced by variety cell types involved in attachment chemotaxis. However, it unknown whether FN regulates macrophages injured lung tissue. Here, we investigated interaction between integrin β1 macrophages, which...