A5035109877- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- Transplantation: Methods and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Inhalation and Respiratory Drug Delivery
- Systemic Sclerosis and Related Diseases
- Respiratory viral infections research
- Sarcoidosis and Beryllium Toxicity Research
- Occupational exposure and asthma
- Rheumatoid Arthritis Research and Therapies
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Immunodeficiency and Autoimmune Disorders
- Autophagy in Disease and Therapy
- COVID-19 Clinical Research Studies
- Organ Transplantation Techniques and Outcomes
- IL-33, ST2, and ILC Pathways
- Pneumonia and Respiratory Infections
- Lung Cancer Treatments and Mutations
- Inflammatory Myopathies and Dermatomyositis
- Pneumocystis jirovecii pneumonia detection and treatment
- Ultrasound and Hyperthermia Applications
- Trauma Management and Diagnosis
- Magnesium in Health and Disease
University of Chicago
2019-2024
Pulmonary and Critical Care Associates
2024
University of Chicago Medical Center
2021
Northwestern University
2015-2020
Jesse Brown VA Medical Center
2015-2020
Ontologically distinct populations of macrophages differentially contribute to organ fibrosis through unknown mechanisms. We applied lineage tracing, single-cell RNA sequencing and single-molecule fluorescence in situ hybridisation a spatially restricted model asbestos-induced pulmonary fibrosis. demonstrate that tissue-resident alveolar macrophages, peribronchial perivascular interstitial monocyte-derived are present the fibrotic niche. Deletion but not ameliorated lung Monocyte-derived...
Alveolar epithelial cell (AEC) mitochondrial dysfunction and apoptosis are important in idiopathic pulmonary fibrosis asbestosis. Sirtuin 3 (SIRT3) detoxifies reactive oxygen species, part, by deacetylating manganese superoxide dismutase (MnSOD) 8-oxoguanine DNA glycosylase. We reasoned that SIRT3 deficiency occurs fibrotic lungs thereby augments AEC mtDNA damage apoptosis. Human were assessed using immunohistochemistry for activity via acetylated MnSODK68. Murine cleaved caspase-9 (CC-9)...
Importance Pulmonary fibrosis (PF) is characterized by progressive scarring of lung tissue and poor survival. Racial ethnic minority populations face the greatest risk morbidity mortality from disparities impacting respiratory health, but pattern age at clinically relevant outcomes across diverse racial with PF unknown. Objective To compare PF-related heterogeneity in survival patterns among Hispanic, non-Hispanic Black, White participants. Design, Setting, Participants This cohort study...
Abstract Pulmonary fibrosis (PF) is characterized by profound scarring and poor survival. We investigated the association of leukocyte telomere length (LTL) with chronological age mortality across racially diverse PF cohorts. LTL measurements among participants stratified race/ethnicity were assessed in relation to all-cause mortality, compared controls. Generalized linear models used evaluate age-LTL relationship, Cox proportional hazards for hazard ratio estimation, Cochran–Armitage test...
Rationale: Computed tomography (CT) enables noninvasive diagnosis of usual interstitial pneumonia (UIP), but enhanced image analyses are needed to overcome the limitations visual assessment. Objectives: Apply multiple instance learning (MIL) develop an explainable deep algorithm for prediction UIP from CT and validate its performance in independent cohorts. Methods: We trained a MIL using pooled dataset (n=2,143) tested it three populations: data prior publication (n=127), single-institution...
Alveolar epithelial cell (AEC) mitochondrial (mt) DNA damage and fibrotic monocyte-derived alveolar macrophages (Mo-AMs) are implicated in the pathobiology of pulmonary fibrosis. We showed that sirtuin 3 (SIRT3), a protein regulating fate aging, is deficient AECs idiopathic fibrosis (IPF) patients asbestos- bleomycin-induced lung augmented Sirt3 knockout (Sirt3−/−) mice associated with AEC mtDNA intrinsic apoptosis. determined whether whole body transgenic SIRT3 overexpression (Sirt3Tg)...
Alveolar epithelial cell (AEC) apoptosis, arising from mitochondrial dysfunction and mitophagy defects, is important in mediating idiopathic pulmonary fibrosis (IPF). Our group established a role for the (mt) DNA base excision repair enzyme, 8-oxoguanine-DNA glycosylase 1 (mtOGG1), preventing oxidant-induced AEC mtDNA damage apoptosis showed that OGG1-deficient mice have increased lung fibrosis. Herein, we determined whether overexpressing mtOGG1 transgene ( mtOgg1 tg ) are protected against...
Tobacco smoking is an established cause of pulmonary disease whose contribution to interstitial lung (ILD) incompletely characterized. We hypothesized that compared with nonsmokers, subjects who smoked tobacco would differ in their clinical phenotype and have greater mortality. performed a retrospective cohort study ILD. evaluated demographic characteristics, time clinically meaningful function decline (LFD), mortality patients stratified by status (ever vs. never) within tertiary center ILD...
Alveolar epithelial cell (AEC) apoptosis and inadequate repair resulting from “exaggerated” lung aging mitochondrial dysfunction are critical determinants promoting fibrosis. α-Klotho, which is an antiaging molecule that expressed predominantly in the kidney secreted blood, can protect cells against hyperoxia-induced apoptosis. We reasoned Klotho protects AEC exposed to oxidative stress part by maintaining DNA (mtDNA) integrity mitigating find levels decreased both serum alveolar type II...
Purpose To compare the diagnostic performance of American Thoracic Society, Japanese Respiratory and Asociación Latinoamericana del Tórax (ATS/JRS/ALAT) versus College Chest Physicians (ACCP) imaging classifications for hypersensitivity pneumonitis (HP). Materials Methods Patients in institutional review board-approved Interstitial Lung Disease (ILD) registry referred multidisciplinary discussion (MDD) at authors' institution (January 1, 2006-April 2021) were included this retrospective...
Abstract Rheumatoid arthritis-related interstitial lung disease (RA-ILD) is a common connective tissue disease-related ILD (CTD-ILD) associated with high morbidity and mortality. Although rheumatoid factor (RF) seropositivity risk for developing RA-ILD, the relationship between RF seropositivity, mediastinal lymph node (MLN) features, progression unknown. We aimed to determine if high-titer predicted MLN function impairment, mortality in RA-ILD. In this retrospective cohort study, we...
Occupational risk factors for interstitial lung disease (ILD) are a remediable aspect of this progressive pulmonary disorder. The association between firefighting and ILD is unknown. Our objective was to assess the characteristics firefighters with from large single-center registry.The University Chicago database reviewed patients history firefighting. Clinical information abstracted medical record. prevalence rate ratio in compared baseline metropolitan area calculated via Poisson...
Abstract Ontologically distinct populations of macrophages differentially contribute to organ fibrosis through unknown mechanisms. We applied lineage tracing, spatial methods and single-cell RNA-seq a spatially-restricted model asbestos-induced pulmonary fibrosis. demonstrate that while tissue-resident interstitial macrophages, alveolar monocyte-derived are present in the fibrotic niche, only causally related Monocyte-derived were specifically localized regions proximity fibroblasts where...