A5020091275- Hemoglobin structure and function
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Research studies in Vietnam
- Cancer Immunotherapy and Biomarkers
- Liver physiology and pathology
- Hepatitis C virus research
- Erythrocyte Function and Pathophysiology
- Traditional and Medicinal Uses of Annonaceae
- Hepatitis B Virus Studies
- Neonatal Health and Biochemistry
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Dendrimers and Hyperbranched Polymers
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Phytochemistry and Biological Activities
- Advanced biosensing and bioanalysis techniques
- Plant-derived Lignans Synthesis and Bioactivity
- Virus-based gene therapy research
- Liver Disease and Transplantation
- Immunotherapy and Immune Responses
- Nitric Oxide and Endothelin Effects
- Heme Oxygenase-1 and Carbon Monoxide
Chungnam National University
2015-2025
Hanoi University of Science and Technology
2021-2025
VNU University of Science
2025
Tokyo Metropolitan University
2022-2024
Osaka Metropolitan University
2022-2024
Vietnam Academy of Science and Technology
2024
Hung Vuong University
2023
Ho Chi Minh City Open University
2020-2023
Osaka City University
2013-2022
Can Tho University
2022
Long-term senescent cells exhibit a secretome termed the senescence-associated secretory phenotype (SASP). Although mechanisms of SASP factor induction have been intensively studied, release mechanism and how factors influence tumorigenesis in biological context remain unclear. In this study, using mouse model obesity-induced hepatocellular carcinoma (HCC), we identified factors, which include interleukin-1β (IL-1β)- IL-1β-dependent IL-33, from hepatic stellate (HSCs) via gasdermin D (GSDMD)...
Abstract The identity of the specific nitric oxide dioxygenase (NOD) that serves as main in vivo regulator O 2 -dependent NO degradation smooth muscle remains elusive. Cytoglobin (Cygb) is a recently discovered globin expressed fibroblasts and cells with unknown function. Cygb, coupled cellular reducing system, efficiently regulates rate consumption by metabolizing an manner decreased physiological hypoxia. Here we show Cygb major cardiovascular tone. Knockout greatly prolongs decay,...
Abstract Recently, mRNA‐based therapeutics, including vaccines, have gained significant attention in the field of gene therapy for treating various diseases. Among mRNA delivery vehicles, lipid nanoparticles (LNPs) emerged as promising vehicles packaging and delivering with low immunogenicity. However, while has several advantages, efficiency stability LNPs remain challenging therapy. In this study, an ionizable helper cholesterol analog, 3β[L‐histidinamide‐carbamoyl] (Hchol) is developed...
In hepatocellular carcinoma (HCC), the clinical significance of soluble immune checkpoint protein levels as predictors patient outcomes or therapeutic responses has yet to be defined. This study profiled baseline sixteen proteins and their changes following sorafenib treatment for HCC. Plasma samples were obtained from 53 patients with advanced HCC at baseline, week 1, 2 4 tested concentrations 16 using multiplexed fluorescent bead-based immunoassays. Multivariate analysis showed high sBTLA...
Cytoglobin (CYGB) is ubiquitously expressed in the cytoplasm of fibroblastic cells many organs, including hepatic stellate cells. As yet, there no specific marker with which to distinguish from myofibroblasts human liver. To investigate whether CYGB can be utilized normal and fibrotic liver, liver tissues damaged by infection hepatitis C virus (HCV) at different stages fibrosis were obtained biopsy. Immunohistochemistry was performed on histological sections using antibodies against CYGB,...
Abstract Cytoglobin (Cygb) was identified in hepatic stellate cells (HSCs) and pericytes of all organs; however, the effects Cygb on cellular functions remain unclear. Here, we report spontaneous age-dependent malformations multiple organs −/− mice. Twenty-six percent young mice (<1 year old) showed heart hypertrophy, cystic disease kidney or ovary, loss balance, liver fibrosis lymphoma. Furthermore, 71.3% (82/115) aged (1–2 years exhibited abnormalities, such as hypertrophy cancer...
Aims: Cytoglobin (CYGB) is a member of the mammalian globin family respiratory proteins. Despite extensive research efforts, its physiological role remains largely unknown, but potential functions include reactive oxygen species (ROS) detoxification and signaling. Accumulating evidence suggests that ROS play crucial in podocyte detachment apoptosis during diabetic kidney disease. This study aimed to explore antioxidative renal CYGB both vivo vitro. Results: Using Cygb-deficient mouse model,...
Dendrimer micelles with glycyrrhizic acid (GA) were developed for anti-inflammatory therapy of acute lung injury (ALI). Cholesterol was conjugated to histidine- and arginine-grafted polyamidoamine (PamHR) micelle formation. The cholesterol-conjugated PamHR (PamHRchol) mixed amphiphilic GA produce PamHRchol/GA micelles. integrated into the had two functions: it acted as an drug facilitated intracellular gene delivery. formed stable complexes plasmid DNA. Integrating increased their...
Study on the chemical components from roots of Aganonerion polymorphum resulted in isolation a new and six first isolated compounds. The structure compound was definitively determined by employment multiple spectroscopic techniques, hydrolysis reaction, followed HPLC‐MS analysis comparison with those reported literature. All compounds were evaluated for inhibitory effect LPS induced nitric oxide (NO) production RAW264.7 cells. Compounds 1, 4, 6, 7 demonstrated IC50 values 4.71 ± 0.08, 7.89...
Symplocos sumuntia Buch-Ham ex D Don is traditionally used to relieve inflammation in Vietnam. This study described a chemical investigation that led isolation and identification of one new nine known compounds. Their structures were determined by using spectroscopic techniques. Compounds 1 - 10 possessed inhibitory activities on NO production induced LPS activated macrophages. Among them, compounds 2 3 demonstrated strong ability reduce with IC50 values 3.91 ± 0.05 3.96 0.24 µM,...
•Reactive oxygen species levels are increased in advanced NASH-related fibrosis.•CYGB directly scavenges •OH and attenuates 8-OHdG generation human HSCs.•CYGB downregulation by TGF-β1 leads to oxidative DNA damage HSCs.•TGF-β1 suppresses CYGB expression HSCs via the pSMAD2/SP3-M1 pathway.•CYGB is absent pSMAD2+8-OHdG+ fibrosis. Background & AimsCytoglobin (CYGB) a respiratory protein that acts as scavenger of reactive species. The molecular role hepatic stellate cell (HSC) activation liver...
This study aimed to measure the rate of depression, anxiety and stress among ethnic minority adolescents identify relationships between demographic characteristics, behaviours adverse childhood experiences (ACEs) factors with different mental disorders. A cross-sectional was conducted in Lang Son province, Vietnam, boarding schools for minorities. The Depression-Anxiety-Stress Scale–21 (DASS-21) ACEs Questionnaire were used. Information on age, gender, ethnicity, frequency home visits,...
Để đưa ra kết luận giám định ADN phục vụ truy nguyên cá thể hoặc xác quan hệ huyết thống, cần kèm theo con số suất dựa trên dữ liệu tần alen và kiểu gen đặc trưng cho mỗi quần thể. Việc sử dụng 21 locus STR lõi trong hình sự đã được thực hiện rộng rãi thế giới ở Việt Nam, tuy nhiên của các mở người (Kinh) vẫn còn thiếu. Trong nghiên cứu này, chỉ đánh giá tính đa toán khảo sát nhằm xây dựng bảng về bộ kit GlobalFiler. Kết quả gen, một điểm di truyền như có cao nhất thấp nhất, phổ biến. là...
O. indicum là một cây thuốc được sử dụng trong y học cổ truyền ở nhiều nước khác nhau trên thế giới. Nghiên cứu này nhằm đánh giá hiệu quả chống lại tế bào ung thư gan HepG2 của dịch chiết ethanol từ lá, vỏ thân và rễ của indicum. Sàng lọc MTT áp để phân tích tác động dịch lên sự tăng sinh bào, apoptosis phát hiện qua nhuộm nhân với DAPI và sản ROS đánh giá thông huỳnh quang H2DCFDA. Kết quả cho thấy, đã làm giảm đáng kể gây ra kiểu hình tuỳ thuộc vào liều lượng. Trong đó,...
Abstract This study clarified the role of Cygb, fourth globin in mammals originally discovered rat hepatic stellate cells (HSCs), cholestatic liver disease. Bile duct ligation (BDL) augmented inflammatory reactions as revealed by increased infiltrating neutrophils, CD68 + -macrophages, and chemokine expression Cygb −/− mice. In these mice, impairment bile canalicular indicated loss CD10 expression, down-regulation salt transporters, total acid, massive apoptotic necrotic hepatocytes occurred...