A5037109715- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biliary and Gastrointestinal Fistulas
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Phagocytosis and Immune Regulation
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Tracheal and airway disorders
- Peroxisome Proliferator-Activated Receptors
- Hepatocellular Carcinoma Treatment and Prognosis
- Metastasis and carcinoma case studies
- Appendicitis Diagnosis and Management
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Platelet Disorders and Treatments
- Abdominal vascular conditions and treatments
- Oral and Maxillofacial Pathology
- Endometrial and Cervical Cancer Treatments
National Kyushu Medical Center
2019-2024
Clinical Research Institute
2023
Kyushu Rosai Hospital
2014
Kyushu University
2007-2011
Beppu Medical Center
2010
National Hospital Organization
2010
SUNY Downstate Health Sciences University
2008
Ministry of Education, Culture, Sports, Science and Technology
2007
Ministry of Health Labour and Welfare
2007
Oita Medical Center
1989
To clarify whether serum chemokine and cytokine levels can become useful biological functional markers to assess the severity of chronic pancreatitis (CP). This study aimed at clarifying CP.Serum monocyte chemoattractant protein-1 (MCP-1), transforming growth factor beta-1 (TGF-beta1), soluble type fractalkine (s-fractalkine) concentrations were examined in patients with CP (n = 109) healthy controls 116). Severity disease was classified by a staging system. Relationships between...
Endoscopic treatment for malignant biliary obstruction (MBO) in patients bearing surgically altered anatomy (SAA) is not well-established. Although endoscopic ultrasound-guided drainage (EUS-BD) has emerged as a new option MBO, limited data are available regarding the efficacy and safety of EUS-BD with SAA. We conducted multicenter prospective registration study to evaluate this population.This involved 10 referral centers Japan. Patients SAA who were scheduled receive unresectable MBO...
A 75-year-old man was referred to our hospital for endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB). He had no remarkable medical history and not receiving anticoagulant therapy. Laboratory testing revealed a normal platelet count coagulation profile. mass in the pancreatic tail been noted on computed tomography at previous hospital. Because autoimmune pancreatitis suspected from imaging studies, we used 19-gauge needle (EchoTip ProCore; Cook Medical, Bloomington, Indiana, USA;...
Objectives: Chronic pancreatitis consists of excessive leukocyte infiltration and fibrosis. IS-741 has been reported to be an antiinflammatory drug through inhibitory action on cell adhesion. In this study, we investigated whether could inhibit the progression pancreatic fibrosis monocyte infiltration. Moreover, effect rat stellate cells (PSCs). Methods: was induced by dibutyltin dichloride in rats. From days 7 28 after application, or distilled water administered. At 14 28, histological...
Background/Aims: Although endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is performed globally, the procedure remains challenging. Guidewire manipulation most difficult step, and there are few reports on factors associated with unsuccessful guidewire manipulation. This study aimed to assess significance of puncture angle EUS images identify effective rescue method for patients manipulation.Methods: We retrospectively enrolled 115 who underwent EUS-HGS between May 2016 April 2022...
To evaluate the chemoradiotherapy for locally advanced pancreatic cancer utilizing low dose gemcitabine as a radiation sensitizer administered twice weekly.We performed retrospective analysis of weekly at 40 mg/m(2). After that, maintenance systemic chemotherapy with gemcitabine, 1000 mg/m(2), was 3 wk 1-wk rest until disease progression or unacceptable toxicity developed.Eighteen patients unresectable were enrolled. Three those could not continue therapy; one patient had interstitial...
Abstract Endoscopic duodenal stent (DS) placement for malignant gastric outlet obstruction (GOO) is rapidly increasing in clinical practice; however, the most suitable patient candidates DS have not been determined. One hundred and thirty-five patients with GOO who underwent three Japanese referral centers between January 2010 October 2019 were retrospectively evaluated. Overall survival (OS) after placement, technical/clinical success rates, adverse events, predictive factors affecting OS...
Patients with acute cholecystitis (AC) after metallic stent (MS) placement for malignant biliary obstruction (MBO) have a high surgical risk. We performed percutaneous transhepatic gallbladder aspiration (PTGBA) as the first treatment AC. aimed to identify risk factors AC MS and poor response of PTGBA.We enrolled 401 patients who underwent MBO between April 2011 March 2020. The incidence was 10.7%. Of these 43 patients, 37 PTGBA treatment. patients' responses were divided into good...
Gemcitabine (GEM) is a gold-standard chemotherapy agent for advanced pancreatic cancer. Because of the malignant character disease, nearly all patients show disease progression despite treatment with GEM-based chemotherapy; therefore, second-line may be beneficial these patients. We report retrospective analysis 5 cancer, treated paclitaxel-containing regimen as second-, third- or fourth-line after various therapies, such regimen, S-1 and chemoradiation. retrospectively analyzed efficacy...
症例は54歳, 男性. 当科初診の4カ月前に近医にて糖尿病と診断され, 内服加療を開始された. その後3カ月間で約8kgの体重減少を認め, さらに左側腹部痛が出現した. 画像検査にて膵癌が疑われたため, 平成15年11月に当科紹介受診となる. 初診時, 右鼠径部に圧痛を伴う径4cmの腫瘤を触知した. 腹部CTでは, 膵尾部から脾門部へ浸潤する径5cmの腫瘤と, 多発性肝内腫瘤および右精索腫瘤を認めた. ERPにて膵尾部主膵管の急峻な途絶像を認め, 肝腫瘍生検の結果は腺癌であった. 以上より, 肝および右精索転移を伴うStage IVbの膵尾部癌と診断し, UFT併用Gemcitabine療法を開始した. 治療に伴い腫瘍マーカーは低下, 原発巣および転移巣は縮小した. 膵癌の精索転移は稀であり, 精索への転移経路として血行性およびリンパ行性が考えられた.
Carcinoma of the ampulla Vater with distant metastases is regarded as unresectable. Systemic chemotherapy basically treatment choice for such tumors. A 68-year-old woman was referred to our hospital and diagnosed carcinoma lymph node multiple liver metastases. She underwent systemic a combination gemcitabine cisplatin. After 19 months treatment, primary tumor were difficult detect on follow-up images. Shrinkage enlarged nodes also confirmed. Surgical resection performed curative intent after...
A 51-year-old woman underwent endoscopic biliary drainage with a plastic stent for obstructive jaundice due to unresectable pancreatic head cancer. During chemotherapy following heavy ion therapy the cancer, she presented acute cholangitis and massive rectal bleeding. The hemorrhage was caused by rupture of duct pseudoaneurysm in right hepatic artery. position aneurysm coincided liver-side end stent. Sustained irritation arterial bile walls considered have contributed formation aneurysm.
Abstract Background Gastroenteric neuroendocrine carcinomas (NECs) account for 6.2% of gastroenteric tumors (NETs), and only 1% or less NETs occur in the ampulla Vater (AoV). Clinical features NEC AoV remain obscure. Case presentation A 65-year-old man visited a general practitioner because jaundice, an abdominal contrast-enhanced computed tomography scan revealed tumor 11 mm diameter, which was enhanced arterial phase at duodenal papilla, with dilation upstream bile duct. Gastrointestinal...
: Gemcitabine (GEM) is widely recognized to be an effective chemotherapy for advanced pancreatic cancer. Some clinical trials of combined with GEM and other anti-cancer drugs have shown greater therapeutic effectiveness. We here report a case 63-year-old woman diagnosed gastric double cancers. After systemic using S-1, the sizes both cancers tumor marker levels were gradually reduced. Our showed that S-1 was very useful treat cancer cancer, suggested synergistic effect two against such
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Malignant gastroduodenal outlet obstruction (MGOO) is occasionally seen in patients with advanced pancreatic cancer. The endoscopic placement of self-expandable metallic stents (SEMS) has proven to be an effective treatment for MGOO [1] [2]. However, the optimal that recurs after a duodenal SEMS remains unknown. Although few reports have shown argon plasma coagulation (APC) treating stenosis esophagogastric [3] [4] [5], application APC malfunction not yet been reported. Hence, we are first...
EUS-guided hepaticogastrostomy (EUS-HGS) is performed for benign biliary diseases as an alternative therapy ERCP. However, a critical adverse event such stent migration was reported.[1] Recently, retrieval method in the HGS route using Spy bite (Boston Scientific, Marlborough, Massachusetts, USA),[2] forceps,[3] or balloon[4] has been reported. We report case that plastic (PS) basket Scientific) [Figure 1] and grasping flap of PS efficient new method.Figure 1: USA)A 70-year-old man with...
Abdominal computed tomography revealed a 19×13mm delayed enhancing mass and dilation of the distal pancreatic duct in head pancreas. Magnetic resonance cholangiopancreatography showed stenosis tail Endoscopic retrograde pancreatography an abrupt interruption main at We could not assess side due to large extent obstruction. The was diagnosed as adenocarcinoma using endoscopic ultrasound-fine needle aspiration biopsy. However, we determine whether pancreas malignant. Nevertheless, performed...
症例は66歳，男性．上腹部不快感，体重減少を主訴に近医受診．膵腫瘍を指摘され当科紹介入院となった．腹部画像検査にて膵体部に5cm大の腫瘍を認め，超音波内視鏡下腫瘍生検にて膵小細胞癌と診断した．化学療法は，GemcitabineとS-1には効果を認めなかったが，PE療法（cisplatin+etoposide）が著効した．膵小細胞癌は稀であるが，化学療法に高感受性を示すため，正確な診断が重要である．