A5063211365- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Viral Infections and Immunology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Rheumatoid Arthritis Research and Therapies
- Peptidase Inhibition and Analysis
- Smoking Behavior and Cessation
- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
- Biochemical Analysis and Sensing Techniques
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Esophagitis
- Nutrition, Genetics, and Disease
- T-cell and B-cell Immunology
- Nicotinic Acetylcholine Receptors Study
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Heat shock proteins research
Instituto Nacional de Enfermedades Respiratorias
2018-2023
Instituto Politécnico Nacional
2020
Around 50% of rheumatoid arthritis (RA) patients show some extra-articular manifestation, with the lung a usually affected organ; in addition, presence anti-citrullinated protein antibodies (ACPA) is common feature, which caused by citrullination modifications, catalyzed peptidyl arginine deiminases (PAD) enzymes. We aimed to identify single nucleotide variants (SNV) PADI2 and PADI4 genes (PAD2 PAD4 proteins, respectively) associated susceptibility interstitial disease (ILD) RA PAD2 levels....
Heat shock proteins (HSP) genes are a superfamily responsible for encoding highly conserved that important antigen presentation, immune response regulation, and cellular housekeeping processes. These can be increased by stress related to pollution, example, smoke from biomass burning and/or tobacco smoking. Single nucleotide polymorphisms (SNPs) in these could affect the levels of their proteins, as well susceptibility developing lung diseases, such chronic obstructive pulmonary disease...
The pathogenesis of Rheumatoid Arthritis (RA) is not fully understood, probably influenced by genetic and environmental factors. Interstitial Lung Disease (ILD) an extra-articular manifestation RA, which contributes significantly to morbidity mortality. identification anti-HLA antibodies has been useful in the transplantation field; however, its contribution autoimmune diseases as RA studied. We aimed determine presence patients with without ILD possible association clinical biochemical...
Genetic variability defends us against pathogen-driven antigens; human leucocyte antigens (HLA) is the immunological system in charge of this work. The Mexican mestizo population arises mainly from mixture three founder populations; Amerindian, Spaniards, and a smaller proportion African population. We describe allele haplotype frequencies HLA class I (-A -B) II (-DRB1 -DQB1), which were analyzed by PCR-SSP urban populations Mexico: Chihuahua-Chihuahua City (n = 88), Mexico City-Tlalpan...
Asthma is a complex and chronic inflammatory airway disease. Asthma's etiology unknown; however, genetic environmental factors could affect disease susceptibility. We designed case-control study aimed to evaluate the role of single-nucleotide polymorphisms (SNP), copy-number variants (CNV) in IL4 IL13 genes asthma susceptibility their participation plasma cytokine levels depending on genotypes Methods: include 486 subjects, divided into patients (AP, n = 141) clinically healthy subjects...
Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by joint inflammation. It presents extra-articular manifestations, with the lungs being one of affected areas. Among these, damage to pulmonary interstitium (Interstitial Lung Disease—ILD) has been linked proteins involved in inflammatory process and related extracellular matrix deposition lung fibrosis establishment. Peptidyl arginine deiminase enzymes (PAD), which carry out protein citrullination, play a role this...
Interstitial lung abnormalities (ILA) are defined as the presence of different patterns increased density, including ground glass attenuation and reticular opacities on chest high-resolution computed tomography (HRCT). In this study, we included 90 subjects with ILA 189 healthy controls (HC) from our Aging Lung Program. We found that older, have a significant smoking history, worse pulmonary function than HC (p < 0.05). When evaluated allele frequencies human leukocyte antigen (HLA)...
Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by joint inflammation. It presents extra-articular manifestations, with the lungs one of affected areas. Among these, damage to pulmonary interstitium (Interstitial Lung Disease -ILD) has been linked proteins involved in inflammatory process and related extracellular matrix deposition lung fibrosis establishment. Peptidyl arginine deiminase enzymes (PAD), which carry out protein citrullination, play a role this context....
<b>Introduction:</b> Tobacco smoking is a complex and multifactorial disease involving both environmental genetic factors. In Mexican mestizo population, single-nucleotide polymorphisms (SNP) associated with cigarette greater degree of nicotine addiction have been identified; however, no possible roles explored the age initiation smoking, nor in success quitting smoking. <b>Methods:</b> present study 151 smokers were included, grouped according to at which they started (table 1), those who...