A5032354687- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Peptidase Inhibition and Analysis
- Diabetes Treatment and Management
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- Healthcare Systems and Practices
- Muscle activation and electromyography studies
- Elasticity and Material Modeling
- Solid-state spectroscopy and crystallography
- Statistical Methods and Bayesian Inference
- Electrochemical Analysis and Applications
- Connexins and lens biology
- Chronic Disease Management Strategies
- Medication Adherence and Compliance
- Cardiovascular and Diving-Related Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Medical Imaging Techniques and Applications
- Statistical Methods and Inference
Chang Gung University
2014-2025
Taoyuan Chang Gung Memorial Hospital
2025
Chang Gung Memorial Hospital
2014-2024
Memorial Hospital of South Bend
2020
Chiayi Chang Gung Memorial Hospital
2020
Linkou Chang Gung Memorial Hospital
2020
Tao Yuan General Hospital
2015
Texas Historical Commission
2014
Cedars-Sinai Medical Center
2005
Chung Yuan Christian University
2005
As the number of cardiac implantable electronic devices (CIEDs) is increasing annually, CIED-related complications are becoming increasingly important. The aim study was to assess risks associated with CIEDs by a nationwide database. Patients were selected from Taiwan National Health Insurance Database. Admissions for CIED implantation, replacement, and revision evaluated evaluation period 14 years. Endpoints included infection, pneumothorax, heart perforation. 40,608 patients mean age 71.8...
The electrophysiological mechanisms underlying melatonin’s actions and the consequences of superimposed therapeutic hypothermia (TH) in preventing cardiac ischemia-reperfusion (IR) injury-induced arrhythmias remain largely unknown. This study aimed to unveil these issues using acute IR-injured hearts. Rabbits were divided into heart failure (HF), HF+melatonin, control, control+melatonin groups. HF was induced by rapid right ventricular pacing. Melatonin administered orally (10 mg/kg/day) for...
Left ventricular systolic dysfunction (LVSD) characterized by a reduced left ejection fraction (LVEF) is associated with adverse patient outcomes. We aimed to build deep neural network (DNN)-based model using standard 12-lead electrocardiogram (ECG) screen for LVSD and stratify prognosis.This retrospective chart review study was conducted data from consecutive adults who underwent ECG examinations at Chang Gung Memorial Hospital in Taiwan between October 2007 December 2019. DNN models were...
Aims: Curved M-mode images of global strain (GS) and rate (GSR) provide sufficiently detailed spatiotemporal information deformation mechanics. This study investigated whether a deep convolutional neural network (CNN) could accurately classify these in patients with atrial fibrillation (AF) who underwent radiofrequency catheter ablation (RFCA) different outcomes. Methods Results: We retrospectively evaluated 606 consecutive RFCA for drug-refractory AF. Patients were divided into AF-free ( n...
The cerebrovascular safety and efficacy of sitagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes mellitus (T2DM) ischemic stroke remains uncertain. aim this study was to assess the sitagliptin T2DM recent stroke. We analyzed data from Taiwan National Health Insurance Research Database between March 1, 2009, December 31, 2011. Ischemic were identified individuals T2DM. Patients who received compared those did not evaluate cardiovascular sitagliptin. primary outcome...
Background The cardiovascular safety and efficacy of sitagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, in type 2 diabetic patients after acute myocardial infarction (AMI) has so far remained uncertain. Methods We analyzed data from the National Health Insurance Research Database (NHIRD), government-operated, population-based database, March 1st, 2009 to December 31st, 2011. Type hospitalized for AMI were included our study. compared subjects using sitagliptin with comparison group...
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce new-onset atrial fibrillation (AF) in patients with type diabetes mellitus (T2DM). We aimed to determine the long-term effects of SGLT2i on tachyarrhythmia recurrence after catheter ablation (CA) T2DM patients.
Abstract Aims This study aimed to compare the efficacy of angiotensin receptor–neprilysin inhibitor (ARNI) therapy with receptor blocker (ARB) for cardiovascular outcomes in patients heart failure (HF) reduced ejection fraction. Methods and results Data were obtained from Chang Gung Research Database. The cohort entry date ARB group was assigned as that ARNI avoid immortal time bias. Additionally, 1:1 propensity score matching based on age, sex, baseline left ventricular fraction conducted....
The therapeutic effect of low-voltage area (LVA)-guided left atrial (LA) linear ablation for non-paroxysmal fibrillation (non-PAF) is uncertain. We aimed to investigate the efficacy LA based on preexisting LVA and its effects reverse remodeling in non-PAF patients.We retrospectively evaluated 145 consecutive patients who underwent radiofrequency catheter drug-refractory non-PAF. CARTO-guided bipolar voltage mapping was performed (AF). defined as sites with ≤ 0.5 mV. If circumferential...
Left atrial (LA) dimension ≥50 mm had approximately four times the risk of developing fibrillation (AF). The aim this study was to investigate whether application clinical and echocardiographic parameters could differentiate between patients having severely dilated left atrium with without AF.This retrospective cross-sectional enrolled consecutive LA divided them into three groups: no AF (no-AF), paroxysmal (PAF) non-paroxysmal (non-PAF) groups. For PAF non-PAF groups, all underwent...
Piceatannol, a grape-derived polyphenol, has been linked to proarrhythmic properties by aggravating inhomogeneous conduction delay in the ischemia-reperfusion (IR) zone enhance arrhythmogenic alternans heart failure (HF) rabbits. The underlying molecular mechanisms of piceatannol-induced disturbance were unclear this model.HF was induced 4 weeks' rapid ventricular pacing. IR injury vivo using protocol left coronary artery ligation and release. Left cardiomyocytes isolated enzymatically for...
<h2>Abstract</h2><h3>Background</h3> The role of P wave in identifying left atrial enlargement (LAE) using artificial intelligence (AI)-enabled electrocardiogram (ECG) models is unclear. It also unknown if AI-enabled single-lead ECGs could be used as a diagnostic tool for LAE surveillance. We aimed to build P-wave and ECG identify sinus rhythm (SR) and/or non-SR ECGs, compared the prognostic ability severe diameter (LAD) ≥50 mm assessed by echocardiography. <h3>Methods</h3> This...
The presence of a Gore-Tex patch can create difficulty in performing transeptal puncture for atrial septal defect patients underwent fibrillation ablation. maneuverability and stability using manually operated catheters via retrograde aortic approach could be overcome by large-curved catheter to form loop facilitating approachability all parts left atrium.
Most previous risk prediction models in patients hospitalized for heart failure (HF) are derived from populations Western countries, and it is unclear whether these applicable to Asian populations. This study aimed construct a score system predicting one-year mortality compare the applicability of this with 3C-HF system.We used population Taiwan Society Cardiology-Heart Failure Reduced Ejection Fraction (TSOC-HFrEF) registry, which prospective cohort admitted acute decompensated (ADHF)...
Background The VICTORIA trial demonstrated a significant decrease in cardiovascular events through vericiguat therapy. This study aimed to assess the potential mechanisms responsible for reduction of with therapy rabbit model myocardial infarction (MI). Methods A chronic MI was created coronary artery ligation. Following 4 weeks, hearts were harvested and Langendorff perfused. Subsequently, electrophysiological examinations dual voltage-calcium optical mapping studies conducted at baseline...
The article reported a methodology and system development to locate the area of myocardial dysfunction using Trans-esophageal Echocardiogram (TEE). gated discretely acquired left ventricular TEE images were first delineated reconstructed into 3D wire mesh. In tracing normal vector contour centroid LV chamber, distribution appeared in function natural logarithm decay which was significantly distributed within 1 mm radius. minimum size for evaluation calculated reported. angle vectors tallied....
Abstract Background: Studies have demonstrated that db/db mice increased susceptibility to myocardial ischemia-reperfusion (IR) injury and ventricular tachyarrhythmias (VA). We aimed investigate the antiarrhythmic molecular mechanisms of ranolazine in mouse hearts with acute IR injury.Methods: Ranolazine was administered for 1 week before coronary artery ligation. Diabetic control db/+ were divided into ranolazine-given -nongiven groups. model created by 15-min left ligation 10-min...