A5003156666- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Bacterial Genetics and Biotechnology
- Enzyme Production and Characterization
- RNA and protein synthesis mechanisms
- Catalysis for Biomass Conversion
- Microbial Metabolites in Food Biotechnology
- Microbial Metabolism and Applications
- Insect Pest Control Strategies
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Advanced Cellulose Research Studies
- Cellular transport and secretion
- Traditional and Medicinal Uses of Annonaceae
- Cytokine Signaling Pathways and Interactions
- Postharvest Quality and Shelf Life Management
University of York
2017-2022
Engineering and Physical Sciences Research Council
2016-2018
Biotechnology and Biological Sciences Research Council
2016-2018
University of Nottingham
2013-2018
Aarhus University
2009
Consolidated bioprocessing (CBP) is reliant on the simultaneous enzyme production, saccharification of biomass, and fermentation released sugars into valuable products such as butanol. Clostridial species that produce butanol are, however, unable to grow crystalline cellulose. In contrast, those saccharolytic predominantly ethanol, Clostridium thermocellum cellulolyticum, degrade cellulose with high efficiency due their possession a multienzyme complex termed cellulosome. This has led...
The use of fossil fuels is no longer tenable. Not only are they a finite resource, their damaging the environment through pollution and global warming. Alternative, environmentally friendly, renewable sources chemicals required. To date, focus has been on using lignocellulose as feedstock for microbial fermentation. However, its recalcitrance to deconstruction making development economic processes extremely challenging. One solution generation an organism suitable in consolidated...
While lignocellulose is a promising source of renewable sugars for microbial fermentations, the presence inhibitory compounds in typical lignocellulosic feedstocks, such as furfural, has hindered their utilisation. In Escherichia coli, major route furfural toxicity depletion NADPH pools due to its use substrate by YqhD enzyme that reduces less toxic alcohol form. Here, we examine potential exploiting benzyl dehydrogenases an alternative means provide this same catalytic function but using...
The solventogenic anaerobe Clostridium beijerinckii has potential for use in the sustainable bioconversion of plant‐derived carbohydrates into solvents, such as butanol or acetone. However, relatively few strains have been extensively characterised either at genomic level through exemplification a complete genetic toolkit. To remedy this situation, new strain C. , NCIMB 14988, is selected from among total 55 clostridial isolates capable growth on hexose and pentose sugars. Chosen basis its...
The evolution of gene fusions that result in covalently linked protein domains is widespread bacteria, where spatially coupling domain functionalities can have functional advantages vivo. Fusions to integral membrane proteins are less widely studied but could provide routes enhance function synthetic biology. We the major facilitator superfamily (MFS), as largest family transporter examine extent and nature these proteins. A remarkably diverse variety identified 8 most abundant examples...