A5022225872- Pain Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Axon Guidance and Neuronal Signaling
- Zebrafish Biomedical Research Applications
- Hedgehog Signaling Pathway Studies
- Musculoskeletal pain and rehabilitation
- Ion channel regulation and function
- Epigenetics and DNA Methylation
- Ocular Disorders and Treatments
- Memory and Neural Mechanisms
Institut des Neurosciences Cellulaires et Intégratives
2016-2024
Centre National de la Recherche Scientifique
2016-2024
Institut du Cerveau
2021-2024
Pitié-Salpêtrière Hospital
2024
Sorbonne Université
2024
Inserm
2024
Université de Strasbourg
2013-2020
GluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions in the brain are mostly unknown. Here, we show that expression subunits controls excitability mouse adult cortical and amygdalar circuits via unusual signaling mechanism involving formation excitatory glycine GluN1/GluN3A (eGlyRs) their tonic activation by extracellular glycine. eGlyRs extrasynaptic reside specific neuronal populations, including principal cells basolateral amygdala (BLA) SST-positive...
Interneurons (INs), specifically those in disinhibitory circuits like somatostatin (SST) and vasoactive intestinal peptide (VIP)-INs, are strongly modulated by the behavioral context. Yet, mechanisms which these INs recruited during active states whether their activity is consistent across sensory cortices remain unclear. We now report that mice, locomotor recruits SST-INs primary somatosensory (S1) but not visual (V1) cortex. This diverse engagement of cannot be explained differences VIP-IN...
In the mammalian neocortex, GABAergic interneurons (INs) inhibit cortical networks in profoundly different ways. The extent to which this depends on how INs process excitatory signals along their dendrites is poorly understood. Here, we reveal that functional specialization of two major populations determined by unique association dendritic integration modes with distinct synaptic organization motifs. We found somatostatin (SST)-INs exhibit NMDAR-dependent and uniform synapse density tree....
Abstract Plasticity of inhibitory transmission in the spinal dorsal horn (SDH) is believed to be a key mechanism responsible for pain hypersensitivity neuropathic syndromes. We evaluated this plasticity by recording responses mechanical stimuli silent neurons (nonspontaneously active [NSA]) and showing ongoing activity (spontaneously [SA]) SDH control nerve-injured mice (cuff model). The SA NSA represented 59% 41% recorded neurons, respectively, were predominantly wide dynamic range (WDR)...
Endogenous acetylcholine (ACh) is an important modulator of nociceptive sensory processing in the spinal cord. An increased level ACh induces analgesia both humans and rodents while interfering with cholinergic signaling allodynic, demonstrating that a basal tone modulates responses naïve animals. The plasticity undergone by this system chronic pain situation unknown, mere presence neuropathic animals controversial. We have addressed these issues mice through behavioral experiments,...
Abstract The identity of a glycinergic synapse is maintained presynaptically by the activity surface glycine transporter, GlyT2, which recaptures back to presynaptic terminals preserve vesicular content. GlyT2 loss-of-function mutations cause Hyperekplexia, rare neurological disease in loss neurotransmission causes generalized stiffness and strong motor alterations. However, molecular underpinnings controlling remain poorly understood. In this work, we identify Hedgehog pathway as robust...
Local inhibitory neurons (INs), specifically those involved in disinhibitory circuits like somatostatin (SST) and vasoactive intestinal peptide (VIP)-positive INs, are essential for regulating cortical function during behavior. However, it is unclear the mechanisms by which these INs recruited active states whether their activity consistent across different sensory cortices. We now reveal that mice, locomotor strongly recruits SST-INs primary somatosensory (S1) but not visual (V1) cortex....
Abstract At the spinal cord level, a tone of endogenous acetylcholine (ACh) modulates nociceptive sensory processing. Increasing level ACh induces analgesia in naïve animals or situation acute pain clinics, but whether this is still case situations models chronic controversial. Here, we demonstrate persistence, and even increased impact analgesic cholinergic acting through nicotinic receptors neuropathic mice. The neuropathy does not affect number properties dorsal horn neurons, proposed to...