Abstract Aims To investigate whether fatty liver per se is an independent risk factor of incident type 2 diabetes mellitus (T2DM) in Koreans. Methods We examined the clinical and laboratory data 5372 non‐diabetic participants (3670 men 1702 women; age 46.8 ± 8.4 years, range 20–79 years) who underwent voluntary medical check‐ups 2000 follow‐up examinations 2005. Results Two hundred thirty‐three (4.3%) developed T2DM after 5 years. Univariate analysis showed that development was associated...

Red cell distribution width (RDW) and serum albumin concentration are associated with postoperative outcomes. However, the usefulness of RDW/albumin ratio in burn surgery remains unclear. Therefore, we evaluated association between 90-day mortality after surgery.Between 2013 2020, a retrospective review patients intensive care unit (ICU) was performed. Receiver operating characteristic curve, multivariate Cox logistic regression, regression Kaplan-Meier analyses were conducted to evaluate...

Capsaicin, a major ingredient of hot pepper, is considered to exhibit anti-inflammatory properties. Our previous study demonstrated that capsaicin inhibited the production pro-inflammatory mediators through NF-kappaB inactivation in LPS-stimulated macrophages. In order further clarify mechanism underlying action capsaicin, we investigated whether alters PPARgamma activity, which regulates cytokine TNFalpha. Capsaicin significantly TNFalpha by macrophages dose-dependent manner. Simultaneous...

BACKGROUND: Male patients undergoing transurethral resection of bladder tumors (TURBT) are prone to suffer from catheter-related discomfort (CRBD). Lidocaine administration has been widely performed reduce postoperative pain. Here, the effect intravenous lidocaine on moderate-to-severe CRBD was evaluated in male TURBT. METHODS: Patients were randomly allocated receive (1.5 mg/kg bolus dose followed by a 2 mg/kg/h continuous infusion during intraoperative period, which continued for 1 hour...

Background Catheter-related bladder discomfort occurs because of involuntary contractions the smooth muscle after urinary catheterization. Magnesium is associated with relaxation. This study hypothesized that among patients having transurethral resection tumor, magnesium will reduce incidence postoperative moderate-to-severe catheter-related discomfort. Methods In this double-blind, randomized study, were randomly allocated to group (n = 60) or control 60). group, a 50 mg/kg loading dose...

Abstract Aims Although hyperphagia is a common manifestation of diabetes mellitus, data on food craving in patients with are limited. This study compared Type 2 mellitus and control group without diabetes. Methods A total 210 subjects (105 105 age‐, sex‐ BMI‐matched subjects) participated two surveys. The surveys were as follows: the General Food Cravings Questionnaire—Trait, which assesses general trait craving; Questionnaire—State, state or current desire for high‐carbohydrate high‐fat...

Robot-assisted laparoscopic prostatectomy (RALP) requires pneumoperitoneum and the Trendelenburg position to optimize surgical exposure, which can increase intracranial pressure (ICP). Anesthetic agents also influence ICP. We compared effects of propofol sevoflurane on sonographic optic nerve sheath diameter (ONSD) as a surrogate for ICP in prostate cancer patients who underwent RALP. Thirty-six were randomly allocated groups receiving (propofol group, n = 18) or (sevoflurane anesthesia. The...

The nutritional condition of patients is an important prognostic factor in various diseases. Free flap failure a serious complication undergoing free reconstruction, increasing morbidity and hospital costs. We evaluated the predictive factors, including index (PNI), associated with extremity reconstruction. PNI was calculated as follows: 10 × serum albumin (g/dL) + 0.005 total lymphocyte count (per mm3), <40 defined low. Univariate multivariate logistic regression analyses were performed...

Abstract Aims To determine the prevalence of metabolic syndrome according to criteria Adult Treatment Panel III (ATP III) and World Health Organization (WHO). Methods Data were collected from 1108 subjects over 40 years age in Chongup district, a rural area South Korea. We evaluated clinical characteristics two criteria. Results According ATP criteria, central obesity was 0.2% men 27.3% women, which is much lower than Americans. However, similar Of Korean age, 29.4% 39.2% had WHO...

To examine the effects of longitudinal changes in fat mass or lean body on risk Type 2 diabetes Korean adults.Participants included 18 687 adults (aged 20-79 years) who underwent routine medical check-ups 2007-2008 and again 2011-2012 with a mean (range) 4.3 (3.0-5.7) years interval. Total fat, fat-free, soft fat-free masses were determined using bioelectrical impedance.A total 692 subjects (3.7%) developed during follow-up. Those had greater increase percent (2.9 ± 3.0 vs 2.6 3.2 percentage...

Urinary catheterization can cause catheter-related bladder discomfort (CRBD). Ketorolac is widely used for pain control. Therefore, we evaluated the effect of ketorolac on prevention CRBD in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP). All were randomly allocated to group or control group. The primary outcome was above a moderate grade at 0 h postoperatively. 1, 2, and 6 also assessed. Postoperative pain, opioid requirement, ketorolac-related complications,...

Robot-assisted laparoscopic prostatectomy (RALP) is a minimally invasive technique for the treatment of prostate cancer. RALP requires patient to be placed in steep Trendelenburg position, along with pneumoperitoneum, which may increase risk postoperative pulmonary complications (PPCs). This large single-center retrospective study evaluated incidence and factors PPCs 2208 patients who underwent between 2014 2017. Patients were divided into those (PPC group) without (non-PPC PPCs....

Summary Post‐induction hypotension is common and associated with postoperative complications. We hypothesised that pneumatic leg compression reduces post‐induction in elderly patients undergoing robot‐assisted laparoscopic prostatectomy. In this double‐blind randomised study, were allocated randomly to the group (n = 50) or control 50). intervention group, was initiated before induction of anaesthesia. 20 min after anaesthesia induction. The primary outcome incidence these groups. defined as...

The C-reactive protein (CRP)/albumin ratio is a useful index used to represent patient inflammation and nutritional status. Elderly patients are at the highest risk for acute kidney injury (AKI). We clarified impact of preoperative CRP/albumin on AKI evaluated postoperative end-stage renal disease (ESRD) among elderly cystectomy patients.We included ≥ 65 years age who underwent radical cystectomy. Multivariate logistic regression analysis receiver operating characteristic curve were...

Diabet. Med. 28, 319–324 (2011) Abstract Aims To investigate the rate of progression to insulin deficiency in Korean patients with Type 2 diabetes mellitus positive for anti‐GAD antibody (GADA) and determine factors related deficiency. Methods We retrospectively analysed data on 87 GADA‐positive age‐ sex‐matched GADA‐negative diabetes. were further subclassified into high‐titre (≥ 250 WHO units/ml) ( n = 24) low‐titre (< 63) subgroups. Cox proportional hazard analysis was used identify...

Abstract Radical cystectomy is considered the standard treatment for patients with muscle-invasive bladder tumors and has high postoperative complication rates among urological surgeries. High-risk patients, defined as those ≥45 years of age history coronary artery disease, stroke, or peripheral disease ≥65 age, can have a higher incidence cardiac complications. Therefore, we evaluated incidence, risk factors, outcomes myocardial injury after non-cardiac surgery (MINS) in high-risk who...

Abstract Background: Pneumoperitoneum and steep Trendelenburg position during robot-assisted laparoscopic prostatectomy (RALP) can increase intracranial pressure (ICP). Dexmedetomidine, a highly selective alpha-2 adrenergic receptor agonist, cause cerebral vasoconstriction decrease blood flow by stimulating the postsynaptic receptors on vessels. However, effects of dexmedetomidine ICP are controversial have not been evaluated RALP under establishment pneumoperitoneum in position. Therefore,...

Urinary diversion after radical cystectomy is associated with a risk of renal function impairment. A significant decline in the glomerular filtration rate (GFR) (i.e., ≥30% baseline GFR 12 months) long-term We compared between ileal conduit and neobladder urinary diversions months cystectomy. retrospectively included patients. Propensity score-matched analysis was performed. The primary outcome incidence (ileal group) secondary outcomes were change end-stage disease (ESRD) two groups. After...