A novel custom-made 3D silicone printer and two-part Ecoflex resins were used to 3D-print standard-shaped coupon irregular-shaped meniscus structures via a heat-cured extrusion-based method. This article is segmented into three parts: (1) study on the effect of printing parameters dimensional accuracy mechanical properties 3D-printed silicone, (2) reliability failure analysis according ASTM D575 standards under monotonic cyclic compressive loading, (3) cytotoxicity by extraction method ISO...

The development and applications of an organocatalyzed living radical polymerization <italic>via</italic> halogen-bonding catalysis, <italic>i.e.</italic>, reversible complexation mediated (RCMP), are highlighted.

Composite hydrogels have gained great attention as three-dimensional (3D) printing biomaterials because of their enhanced intrinsic mechanical strength and bioactivity compared to pure hydrogels. In most conventional methods for composite hydrogels, particles are preloaded in ink before printing, which often reduces the printability with little improvement due poor particle-hydrogel interaction physical mixing. contrast, situ incorporation nanoparticles into a hydrogel during 3D achieves...

The first successful direct 3D printing, or additive manufacturing (AM), of heat-cured silicone meniscal implants, using biocompatible and bio-implantable resins is reported. Silicone implants have conventionally been manufactured by indirect casting molding methods which are expensive time-consuming. A novel custom-made heat-curing extrusion-based printer capable directly printing medical introduced. rheological study the optimization critical process parameters described in detail. surface...

Osteoarthritis of the knee with meniscal pathologies is a severe pathology suffered by aging population worldwide. However, conventional substitutes are not 3D-printable and lack customizability 3D printed implants mechanically robust enough for human implantation. Similarly, hydrogel scaffolds suffer from drawbacks being weak as result patients unable to execute immediate post-surgical weight-bearing ambulation rehabilitation. To solve this problem, we have developed silicone meniscus...

Biomimetic actuators are critical components of bionics research and have found applications in the fields biomedical devices, soft robotics, smart biosensors. This paper reports first study nanoassembly topology-dependent actuation shape memory programming biomimetic 4D printing. Multi-responsive flower-like block copolymer nanoassemblies (vesicles) utilized as photocurable printing materials for digital light processing (DLP) The enhance thermal stability, attributed to their surface loop...

Biofabrication technologies have endowed us with the capability to fabricate complex biological constructs. However, cytotoxic biofabrication conditions been a major challenge for their clinical application, leading trade-off between cell viability and scalability of biofabricated Taking inspiration from nature, we proposed protection strategy which mimicks protected dormant state plant seeds in adverse external germination response appropriate environmental cues. Applying this bioinspired...

Mechanical properties of hydrogel particles are importance for their interactions with cells or tissue, apart from relevance to other applications. While so far the majority works aiming at tuning particle mechanics relied on chemical cross-linking, we report a novel approach using inwards interweaving self-assembly poly(allylamine) (PA) and poly(styrenesulfonic acid) (PSSA) agarose gel beads. Using this technique, shell thicknesses up tens micrometers can be achieved single-polymer...

Controls over stimuli-responsive functional materials and programmable shape deformations are key features in the four-dimensional (4D) printing of soft actuators. Instead using random copolymers, homopolymers, or natural polymers, this paper reports first use amphiphilic, photocurable, pH-responsive block copolymer (BCP) nanoassemblies digital light processing (DLP) 4D to fabricate smart Programmable actuation was studied via a bottom-up approach: (1) designed synthesis BCPs, (2)...

Abstract The unique inwards interweaving morphology of polyamines and polyacids within agarose hydrogels that leads to the formation striated shells with different porosities spherical scaffold is reported. Microcompartments sophisticated structures are commonly used in drug delivery, tissue engineering, other biomedical applications. However, a method capable producing well‐defined, multiporous single compartment still lacking. By alternating deposition polyallylamine (PA)...

Using "Generally Recognized as Safe" (GRAS) materials for assembly, edible polyelectrolytes (EPL/PGA) are coated on sugar (maltotriose)–dextran particles and crosslinked (left). Cargo-loaded hollow capsules created by dissolution of the template (right).

Hydrogels with complex internal structures are required for advanced drug delivery systems and tissue engineering or used as inks 3D printing. However, hydrogels lack the tunability diversity of polymeric shells require complicated postsynthesis steps to alter its structure properties. We report on first integrated approach assemble design take various functions such multilayer nanofilms, multidensity immobilization matrix, multiadhesive chromatography resins via tuning four assembly...

A nano-capsule synthesized via self-catalyzed RCMP and its use as a heterogeneous catalyst nano-reactor of to generate multi-elemental particle.

In the presence of alkynes (CHC–R²), iodide chain-end polymers (Polymer–I) were successfully transformed to vinyl (Polymer–CHCR²–I) in a single step <italic>via</italic> organocatalysis.

The breakthrough of genetic therapy is set back by the lack suitable vector systems. We present development permeability-tunable, capsule-like, polymeric, micron-sized, core–shell particles for delivery recombinant nucleic acids into target cells. These were demonstrated to effectively release rod-shaped small hairpin RNA and selectively retain RNA-encoding DNA template, which was designed form a bulky tripartite structure. Thus, they can serve as vectors preloaded with cargo or...

The self-assembly of bottlebrush or comb copolymers into well-ordered structures can be accurately controlled to create functional materials for smart elastomeric actuators. However, date, copolymer self-assemblies have only been utilized in fabricating isotropic In this work, we report on the first synthesis anisotropic soft actuators from triblock copolymers. Dumbbell-shaped block (BCPs) with poly(dimethylsiloxane) (PDMS) side chains were crosslinked via poly(butyl acrylate) (PBA) form...

Multiple shells with discrete porosities are created by D. Trau and co-workers on page 5108, within the matrix of a hydrogel. The front cover image illustrates, from both 2D 3D perspectives, increasing density concentric inner- to outermost layer. confocal images reflect unique inwards interweaving behavior polyallylamine (red) polystyrenesulfonic acid (green) produce yellow Intricate multi-porous architectures can be fabricated via this facile easily tunable approach.