A5059118767- HIV/AIDS drug development and treatment
- Heat shock proteins research
- Ubiquitin and proteasome pathways
- Receptor Mechanisms and Signaling
- Cellular transport and secretion
- Migraine and Headache Studies
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Trigeminal Neuralgia and Treatments
- Bioinformatics and Genomic Networks
- Oropharyngeal Anatomy and Pathologies
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- Single-cell and spatial transcriptomics
- DNA Repair Mechanisms
- Biochemical and Molecular Research
Karolinska Institutet
2023-2025
Science for Life Laboratory
2023-2025
Universitat Internacional de Catalunya
2022
Hospital General de Granollers
2022
Report a rigorous SAMHD1 chemical probe discovery pipelineIdentified series of low micromolar inhibitors, exemplified by
Abstract The human genome contains thousands of potentially coding short open reading frames (sORFs). A growing set microproteins translated from these sORFs are known to have important cellular functions. However, the majority remains uncharacterised. Thus, larger screens find functional become more vital. Here, we performed a high-throughput CRISPR/Cas9 knock-out screen with customised library 11,776 sORFs, curated literature and databases identify essential for cancer cell line growth....
Sterile alpha motif and histidine-aspartic acid domain containing protein-1 (SAMHD1) is a deoxynucleoside triphosphate (dNTP) hydrolase that controls dNTP pools detoxifies cancer cells of chemotherapy metabolites. TH6342 recently reported small molecule inhibitor SAMHD1 interacts with the protein in vitro non-competitively prevents dimerisation, prerequisite for catalysis. The binding site on currently unknown. In present study we demonstrate N-terminal SAM not required inhibition by TH6342.
Abstract Sterile alpha motif and histidine-aspartic acid domain containing protein-1 (SAMHD1) is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase central to cellular nucleotide pool homeostasis. Recent literature has also demonstrated how SAMHD1 can detoxify chemotherapy metabolites thereby controlling their clinical responses. To further understand biology investigate the potential of targeting this enzyme as neoadjuvant existing chemotherapies we set out discover selective small...
Trigeminal trophic syndrome (TTS) is a rare condition that arises secondary to damage the peripheral or central sensory pathways of trigeminal nerve.TTS classically presents with triad anesthesia, facial paresthesias, and selfinduced lateral ala nasi ulceration.TTS should be considered in differential diagnoses unilateral ulcerations due unique management it requires.Patient education prevent compulsive manipulation lesion fundamental piece treatment TTS.We describe 65-year-old woman who...