A5058992043- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- Plant nutrient uptake and metabolism
- Plant Molecular Biology Research
- Lipid metabolism and biosynthesis
- Dermatologic Treatments and Research
- Light effects on plants
- Plant Micronutrient Interactions and Effects
- Pain Management and Treatment
- Plant responses to elevated CO2
- Aluminum toxicity and tolerance in plants and animals
- Cardiovascular Effects of Exercise
- Biocrusts and Microbial Ecology
- Veterinary Pharmacology and Anesthesia
- Colorectal Cancer Screening and Detection
- Ultrasound and Hyperthermia Applications
- Plant tissue culture and regeneration
- Photoreceptor and optogenetics research
- Marine and coastal plant biology
- Proteoglycans and glycosaminoglycans research
- Adipose Tissue and Metabolism
- Cancer Genomics and Diagnostics
- Anesthesia and Pain Management
- Peripheral Artery Disease Management
- Viral Infections and Immunology Research
University of Bristol
2013-2022
Origin Sciences (United Kingdom)
2022
University of York
2010-2012
École Polytechnique Fédérale de Lausanne
2005-2006
RELX Group (United Kingdom)
2005
St. Elizabeth's Medical Center
1997-2002
Tufts University
1984-2002
University of Arizona
1990
Tufts Medical Center
1984
An integral part of global environment change is an increase in the atmospheric concentration CO2 ([CO2]) [1Long S.P. Ainsworth E.A. Rogers A. Ort D.R. Rising carbon dioxide: plants FACE future.Annu. Rev. Plant Biol. 2004; 55: 591-628Crossref PubMed Scopus (1316) Google Scholar]. Increased [CO2] reduces leaf stomatal apertures and density stomata that plays out as reductions evapotranspiration [2Mansfield T.A. Hetherington A.M. Atkinson C.J. Some current aspects physiology.Annu. Physiol....
Controversy exists over the role of endomyocardial biopsy in evaluating patients with dilated cardiomyopathy, particularly detecting myocarditis and assessing prognosis. Interobserver variability, if high, could explain conflicting reports. To assess this possibility, we submitted specimens from 16 cardiomyopathy to seven cardiac pathologists. The same slides were independently reviewed by each assessed for fibrosis, hypertrophy, nuclear changes on a 0 3+ scale, mean lymphocyte count per...
S-Adenosylmethionine (SAM) is formed exclusively in the cytosol but plays a major role plastids; SAM can either act as methyl donor for biogenesis of small molecules such prenyllipids and macromolecules or regulator synthesis aspartate-derived amino acids. Because biosynthesis restricted to cytosol, plastids require importer. However, this transporter has not yet been identified. Here, we report molecular functional characterization an Arabidopsis thaliana gene designated TRANSPORTER1...
Potassium (K+) is a major nutrient for plant growth and development. Vacuolar K+ ion channels of the two-pore (TPK) family play an important role in maintaining homeostasis. Several TPK were previously shown to be expressed lytic vacuole (LV) tonoplast. Plants also contain smaller protein storage vacuoles (PSVs) that membrane transporters. However, mechanisms define how proteins reach different vacuolar destinations are largely unknown. The Oryza sativa genome encodes two isoforms (TPKa...
The cyclic nucleotide cGMP has been shown to play important roles in plant development and responses abiotic biotic stress. Yet much controversy remains regarding the exact role of this second messenger. Progress unravelling function plants was hampered by laborious time-consuming methodology measure changes cellular [cGMP] but fluorescence-based reporters removed disadvantage. This study used FlincG reporter investigate potential interactions between phytohormone signalling found a rapid...
• Arsenic contamination has a negative impact on crop cultivation and human health. As yet, no proteins have been identified in plants that mediate the extrusion of arsenic. Here, we heterologously expressed yeast (Saccharomyces cerevisiae) arsenite efflux transporter ACR3 into Arabidopsis to evaluate how this affects plant tolerance tissue arsenic contents. was cloned from transformed wild-type nip7;1 Arabidopsis. determined at cellular level using vitality stains protoplasts, intact...
This paper reviews the status of lasers in treatment cardiovascular disease.
The cyclic nucleotide cGMP has been shown to play important roles in plant development and responses abiotic biotic stress. To date, the techniques that are available measure plants limited by low spatial temporal resolution. In addition, tissue destruction is necessary. circumvent these drawbacks we have used δ-FlincG fluorescent protein create an endogenous sensor can report cellular levels with high resolution time space living cells. transient stably expressing cells shows a dissociation...
All living organisms communicate with their environment, and part of this dialogue is mediated by secondary messengers such as cyclic guanosine mono phosphate (cGMP). In plants, most the specific components that allow production breakdown cGMP have now been identified apart from dependent phosphodiesterases, enzymes responsible for catabolism. Irrespectively, role in plant signal transductions firmly established involvement nucleotide development, stress response, ion homeostasis hormone...
Although UVA radiation (315-400 nm) represents 95% of the UV reaching earth's surface, surprisingly little is known about its effects on plants [1]. We show that in Arabidopsis, short-term exposure to inhibits opening stomata, and this requires a reduction cytosolic level cGMP. This process independent UVR8, UVB receptor. A cGMP-activated phosphodiesterase (AtCN-PDE1) was responsible for UVA-induced decrease cGMP Arabidopsis. AtCN-PDE1-like proteins form clade within large...
This study was designed to test the hypothesis that transcutaneous ultrasound (US) exposure may augment transfection efficiency and biological outcome associated with nonviral DNA gene transfer. Hindlimb muscles of New Zealand White rabbits were transfected reporter plasmid pCMV-β, or without US exposure. Optimization studies employed at various frequencies, mechanical indices, duty cycles, durations exposure, time points. Based on these results, we explored effect transfer vascular...
Percutaneous laser angioplasty has now become a clinical reality, consisting chiefly of applications thermal in conjunction with balloon for the recanalization peripheral vascular obstructions. In this development, various aspects laser-tissue interactions, fiber optic transmission, and delivery catheter design pertinent to cardiovascular system have come under closer scrutiny. This paper examines certain noteworthy concepts that emerged from investigations.
Summary Stomata respond to darkness by closing prevent excessive water loss during the night. Although reorganisation of actin filaments stomatal closure is documented, underlying mechanisms responsible for dark‐induced cytoskeletal arrangement remain largely unknown. We used genetic, physiological and cell biological approaches show that cytoskeleton required closure. The opal5 mutant does not close in response but exhibits wild‐type ( WT ) behaviour when exposed abscisic acid ABA or CaCl 2...
Growth at increased concentrations of CO2 induces a reduction in seed zinc (Zn) and iron (Fe). Using Arabidopsis thaliana, we investigated whether this could be mitigated by reducing the elevated -induced decrease transpiration. We used an infrared imaging-based screen to isolate mutants At1g08080 that encodes ALPHA CARBONIC ANHYDRASE 7 (ACA7). aca7 mutant alleles display wild-type (WT) responses abscisic acid (ABA) light but are compromised their response . ACA7 is expressed guard cells....
Potassium (K) is one of the major nutrients that essential for plant growth and development. The majority cellular K+ resides in vacuole tonoplast channels TPK (Two Pore K) family are main players homeostasis. All were previously reported to be expressed large central lytic (LV) except isoform Arabidopsis plasma membrane. However, cells often contain more than type coexist same cell. We recently showed two isoforms (OsTPKa OsTPKb) from Oryza sativa localise different vacuoles with OsTPKa...