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About
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A5044347746
Research Areas
- Ion channel regulation and function
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Venomous Animal Envenomation and Studies
Fundação Oswaldo Cruz
2018
The action of Cr-LAAO, an l-amino acid oxidase isolated from Calloselasma rhodosthoma snake venom, on NADPH activation in human neutrophil function was investigated. This enzyme has intrinsic activity hydrogen peroxide production. its native form, induces the ROS production and migration cytosolic components p40phox, p47phox p67phox to membrane, Rac, a GTPase protein member, with involvement intracellular signaling mediated by phospho PKC-α. In inactive iCr-LAAO does not induce showing that...
10.1016/j.toxicon.2018.02.046
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publisher-specific-oa
Toxicon
2018-03-02
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