A5047212229- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Uterine Myomas and Treatments
- Gestational Diabetes Research and Management
- Endometriosis Research and Treatment
- Maternal and fetal healthcare
- COVID-19 Impact on Reproduction
- Gynecological conditions and treatments
- Neurological Complications and Syndromes
- Acute Kidney Injury Research
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroinflammation and Neurodegeneration Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Neonatal and fetal brain pathology
- Preterm Birth and Chorioamnionitis
- Atherosclerosis and Cardiovascular Diseases
- Neonatal Respiratory Health Research
- Nitric Oxide and Endothelin Effects
- Sodium Intake and Health
- Infant Development and Preterm Care
- Cardiovascular Issues in Pregnancy
- Hormonal Regulation and Hypertension
- Muscle and Compartmental Disorders
University of Mississippi Medical Center
2016-2025
Jackson Memorial Hospital
2014-2024
University of North Carolina at Chapel Hill
2020-2024
State Street (United States)
2011-2024
Duke University
2019-2023
Clinical Research Institute
2019-2023
Augusta University
2019-2023
Henry Ford Health System
2020-2023
Brigham and Women's Hospital
2019-2023
University of California, San Francisco
2019-2023
Preeclampsia is considered a disease of immunological origin associated with abnormalities in inflammatory cytokines, tumor necrosis factor-α (TNF-α), and activated lymphocytes secreting autoantibodies to the angiotensin II receptor (AT1-AA). Recent studies have also demonstrated that an imbalance angiogenic factors, soluble fms-like tyrosine kinase (sFlt-1), sEndoglin, exists preeclampsia; however, mechanisms initiate their overproduction are unclear. To determine role immune regulation...
Preeclampsia is associated with autoimmune cells T H 17, secreting interleukin-17, autoantibodies activating the angiotensin II type I receptor (AT1-AA), and placental oxidative stress (ROS). The objective of our study was to determine whether chronic IL-17 increases blood pressure by stimulating ROS AT1-AAs during pregnancy. To answer this question four groups rats were examined: normal pregnant (NP, n = 20), NP+IL-17 ( 12), NP+tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine- N-oxyl) 7) (a...
We have shown that hypertension in response to chronic placental ischemia is associated with elevated inflammatory cytokines and CD4(+) T cells. However, it unknown whether these cells play an important role mediating ischemia. Therefore, we hypothesize reduced uterine perfusion pressure (RUPP)-induced increase blood during pregnancy. To answer this question, were isolated from spleens at day 19 of gestation control normal pregnant (NP) RUPP rats, cultured, adjusted 10(6) per 100 μL saline...
Preeclampsia is associated with innate inflammatory response resulting in elevated tumor necrosis factor-α, agonistic autoantibodies to the angiotensin II type I receptor, and activation of endothelin 1 (ET-1). This study was designed determine role B-cell depletion, receptor suppression mediate hypertension via ET-1 placental ischemic reduced uterine perfusion pressure (RUPP) rat model preeclampsia. To achieve this goal we examined effect RUPP on mean arterial presence absence chronically...
Preeclampsia, new onset hypertension with proteinuria during pregnancy, is associated chronic inflammation and placental oxidative stress (ROS). Chronic interleukin-17 (IL-17) increases blood pressure, autoantibodies (angiotensin II type I receptor [AT1-AA]), ROS pregnancy. The objective of this study was to determine whether T-helper 17 (TH17) suppression via IL-17 recombinant C (IL-17RC) decreases pathophysiology ischemia (reduced uterine perfusion pressure [RUPP]). On gestation day 14,...
Anxiety during pregnancy is associated with adverse outcomes in mothers and infants.Unfortunately, as anxiety often synonymously mentioned depression, the studies focusing solely on are not robust those field of depression are.In this work, we provide an overview what currently known about general pregnancy, pregnancy-related potential impacts could have post-partum care.An risk factors, maternal outcomes, infant outcome along pharmacological nonpharmacological treatments covered a specific...
Importance Insulin is recommended for pregnant persons with preexisting type 2 diabetes or diagnosed early in pregnancy. The addition of metformin to insulin may improve neonatal outcomes. Objective To estimate the effect added pregnancy on a composite adverse outcome. Design, Setting, and Participants This randomized clinical trial 17 US centers enrolled adults aged 18 45 years prior 23 weeks’ gestation between April 2019 November 2021. Each participant was treated assigned add either...
BACKGROUND: Patients with preeclampsia exhibit hypertension and chronic inflammation characterized by CD (cluster determinant) 4+T cells, B cells secreting AT1-AA (agonistic autoantibody against the angiotensin II type 1 receptor), inflammatory cytokines, complement activation. Importantly, a history of COVID-19 during pregnancy is associated an increased incidence preeclampsia-like phenotype partly mediated CD4+T cells. We recently showed pregnant patients or without produce AT1-AA,...
Hypertension during preeclampsia is associated with increased maternal vascular sensitivity to angiotensin II (ANGII). This study was designed determine mechanisms whereby agonistic autoantibodies the ANGII type I receptor (AT1-AA) enhance blood pressure (mean arterial [MAP]) and renal pregnancy. First, we examined MAP artery resistance index in response chronic administration of or AT1-AA AT1-AA+ANGII pregnant rats compared control rats. To examine heightened pregnancy, role endogenous...
The reduced uterine perfusion pressure (RUPP) rat model of preeclampsia exhibits much the pathology characterizing this disease, such as hypertension, inflammation, suppressed regulatory T cells (TRegs), reactive oxygen species (ROS), and autoantibodies to ANG II type I receptor (AT1-AA) during pregnancy. objective study was determine whether supplementation normal pregnant (NP) TRegs into RUPP rats would attenuate pathophysiology associated with CD4(+)/CD25(+) were isolated from spleens NP...
Several studies suggest a link between autoimmunity and essential hypertension in humans. However, whether can drive the development of remains unclear. The autoimmune disease systemic lupus erythematosus is characterized by autoantibody production, prevalence increased markedly this patient population compared with normal healthy women. We hypothesized that preventing would prevent mouse model lupus. Female (NZBWF1) control mice (NZW) were treated weekly anti-CD20 or immunoglobulin G...
Hypertension in rats with chronic placental ischemia (reduced uterine perfusion pressure, RUPP) is associated elevated inflammatory cytokines, agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) and CD4 + T cells; all of which are preclamptic women. Additionally, we have shown that adoptive transfer RUPP cells increases blood sFlt-1. The objective this study was determine long-term effects on AT1-AA, renal systemic hemodynamics pregnant rats. To answer question...
Preeclampsia is associated with chronic inflammation and an imbalance among T-helper cell subtypes increase in 17 (TH17) cells. The objective of this study was to determine a role for TH17s, from the reduced uterine perfusion pressure (RUPP) rat model preeclampsia, etiology hypertension during pregnancy. CD4+/CD25- T cells were isolated spleens, cultured TH17 media, verified as TH17s via flow cytometry. On day 12 gestation, 1×106 RUPP rats adoptively transferred into NP rats, carotid...