A5073637056- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Nanoparticle-Based Drug Delivery
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Vaccine Coverage and Hesitancy
- Immunotherapy and Immune Responses
Korea Research Institute of Bioscience and Biotechnology
2024-2025
Ajou University
2019-2024
Lipid nanoparticles (LNPs) are promising mRNA delivery vehicles due to their biocompatibility and tunable characteristics. While current rational design approaches focus on ionizable lipids' pKa zeta potential optimize encapsulation endosomal escape, the selection of helper lipids remains largely empirical. We propose that lipid transition temperature (Tm), marking shift from gel liquid crystalline phase, can guide selection. Through screening 54 lipids, we identified H7T4, which displayed...
Immunotherapy combined with chemicals and genetic engineering tools is emerging as a promising strategy to treat triple-negative breast cancer (TNBC), which more aggressive poorer progress than other subtypes. In this study, lipid-based nanoparticles (LNPs) possessed an NK cell-like function that could deliver tumor-specific therapeutics inhibit tumor growth. LNPs fused cell membrane protein system (NK-LNP) have three main features: (i) hydrophilic plasmid DNA can TNBC metastasis when...
Immunotherapy combined with chemicals and genetic engineering tools is emerging as a promising strategy to treat triple-negative breast cancer (TNBC), which more aggressive poorer progress than other subtypes. In this study, lipid-based nanoparticles (LNPs) possessed an NK cell-like function that could deliver tumor-specific therapeutics regulate the tumor immune microenvironment. Our LNP mimicking cells consists of three characteristics: i) they are hydrophilic therapeutic substances so...
<title>Abstract</title> Introduction: Immunotherapy combined with chemicals and genetic engineering tools is emerging as a promising strategy to treat triple-negative breast cancer (TNBC), which more aggressive poorer progress than other subtypes. In this study, lipid-based nanoparticles (LNPs) possessed an NK cell-like function that could deliver tumor-specific therapeutics regulate the tumor immune microenvironment. Method Our LNP mimicking cells consists of three characteristics: i) they...