A5052880607- Ferrocene Chemistry and Applications
- CRISPR and Genetic Engineering
- Organometallic Complex Synthesis and Catalysis
- Metal complexes synthesis and properties
University of Puerto Rico at Río Piedras
2020
Precise control over the dosage of Cas9-based technologies is essential because off-target effects, mosaicism, chromosomal aberrations, immunogenicity, and genotoxicity can arise with prolonged Cas9 activity. Type II anti-CRISPR proteins (Acrs) inhibit but are generally impermeable to cell membrane due their size (6–54 kDa) anionic charge. Moreover, existing Acr delivery methods long-lived operate within hours ( e . g ., viral non-viral vectors) or not applicable in vivo nucleofection),...
Over time platinum-based anticancer drugs have dominated the market, but their side effects significantly impact quality of life patients. Alternative treatments are being developed all over world. The titanocene and auranofin families compounds, discovered through an empirical search for other metal-based therapeutics, hold tremendous promise to improve outcomes cancer treatment. Herein we present a historical perspective these compounds review current efforts focused on evolution ligands...