A5036831474- Probiotics and Fermented Foods
- Infant Nutrition and Health
- Diet and metabolism studies
- Digestive system and related health
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Alcohol Consumption and Health Effects
- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
- Diabetes Treatment and Management
- Frailty in Older Adults
- Antioxidant Activity and Oxidative Stress
- COVID-19 and Mental Health
- Gambling Behavior and Treatments
- Time Series Analysis and Forecasting
- Nutritional Studies and Diet
- Schizophrenia research and treatment
- Bariatric Surgery and Outcomes
- Nutrition and Health in Aging
- Physical Activity and Health
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
Istituto Superiore di Sanità
2021-2023
The Microsoft Research - University of Trento Centre for Computational and Systems Biology
2015-2019
University of Trento
2015-2018
National Academies of Sciences, Engineering, and Medicine
2013
Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti
2012
Pfizer (United Kingdom)
2011
Bristol-Myers Squibb (Germany)
2011
AstraZeneca (Brazil)
2011
Eli Lilly (Singapore)
2011
Boehringer Ingelheim (India)
2011
Polyphenol-rich foods are part of many nutritional interventions aimed at improving health and preventing cardiometabolic diseases (CMDs). Polyphenols have oxidative, inflammatory, and/or metabolic effects. Research into the chemistry biology polyphenol bioactives is prolific but knowledge their molecular interactions with proteins limited. We mined public data to (i) identify that interact or metabolize polyphenols, (ii) mapped these pathways networks, (iii) annotated functions enriched...
In order to provide a method for precise identification of insulin sensitivity from clinical Oral Glucose Tolerance Test (OGTT) observations, relatively simple mathematical model (Simple Interdependent glucose/insulin MOdel SIMO) the OGTT, which coherently incorporates commonly accepted physiological assumptions (incretin effect and saturating glucose-driven secretion) has been developed. OGTT data 78 patients in five different glucose tolerance groups were analyzed: normal (NGT), impaired...
Constitutional thinness (CT) is a state of low but stable body weight (BMI ≤18 kg/m2). CT subjects have normal-range hormonal profiles and food intake exhibit resistance to gain despite living in the modern world's obesogenic environment.The goal this study identify molecular mechanisms underlying protective phenotype against gain.We conducted clinical overfeeding on 30 controls 20-25 kg/m2) matched for age sex. We performed integrative transcriptomic analyses white adipose muscle...
Weaning is a period of marked physiological change. The introduction solid foods and the changes in milk consumption are accompanied by significant gastrointestinal, immune, developmental, microbial adaptations. Defining reduced number infections as desired health benefit for infants around weaning, we identified silico (i.e., advanced public domain mining) infant gut microbes potential deliverers this benefit. We then investigated requirements these bacteria exogenous metabolites prebiotic...
Frailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial phenotypes. We operationalized biopsychosocial frailty construct, estimating its association with mild cognitive impairment (MCI) subtypes.In 1980, older individuals from population-based Italian PRoject on Epidemiology Alzheimer's disease (IPREA), we investigated cross-sectional associations among frailty, MCI, subtypes.Participants showed an increased odds ratio (OR) MCI [OR:...
The COVID-19 pandemic came along with several health and social unprecedented emergencies, among which handling people substance use disorder issues.In this work, data from a cross-sectional online survey conducted more than 40,000 adults in 21 European countries during the spring of 2020 are analyzed. recorded participants drinking habits year preceding changes alcohol consumption lockdown. analyses focused on consumers' type, investigating behavioral change who already had problematic...
Insulin resistance is considered to be a pathogenetic mechanism in several and diverse diseases (e.g. type 2 diabetes, atherosclerosis) often antedating them apparently healthy subjects. The aim of this study investigate with microarray based approach whether IR per se characterized by specific pattern gene expression. For purpose we analyzed the transcriptomic profile peripheral blood mononuclear cells two groups (10 subjects each) individuals, extreme insulin or sensitivity, matched for...
Abstract Background Consensus exists that several bariatric surgery procedures produce a rapid improvement of glucose homeostasis in obese diabetic patients, apparently uncorrelated with the degree eventual weight loss after surgery. Several hypotheses have been suggested to account for these results: among these, anti-incretin, ghrelin and lower-intestinal dumping discussed literature. Since no clear-cut experimental results are so far available confirm or disprove any hypotheses, present...
Background The pathophysiologic processes underlying the regulation of glucose homeostasis are considerably complex at both cellular and systemic level. A comprehensive structured specification for several layers abstraction metabolism is often elusive, an issue currently solvable with hierarchical description provided by multi-level models. In this study we propose a closed-loop model whole-body homeostasis, coupled molecular specifications insulin signaling cascade in adipocytes, under...
Scope Acute metabolic challenges provide an opportunity to identify mechanisms of and nutritional health. In this study, we assessed the transcriptomic response oral glucose lipid in a cohort individuals ranging age BMI. The main goal is whether BMI can mediate transcriptional dietary challenges, differences between tests. Methods results Two hundred fourteen healthy adults were assigned twenty‐three selected for further proofing, using microarray analysis peripheral blood mononuclear cells....
Background and Scope Weight loss success is dependent on the ability to refrain from regaining lost weight in time. This feature was shown be largely variable among individuals, these differences, with their underlying molecular processes, are diverse not completely elucidated. Altered plasma metabolites concentration could partly explain maintenance mechanisms. In present work, a systems biology approach has been applied investigate potential mechanisms involved within Diogenes weight-loss...
The new revision of the ICD came into effect on January 1st, 2022, and significant changes have been introduced in section related to substance use disorders.In present work we describe ICD-11 "Disorders due Substance Use Addictive Behaviors" outline innovations classification diagnosis introduced, with a view addressing most important issues terms opportunities for identifying caring people need treatment.The main chapter interest are expanded classes psychoactive substances, introduction...
In longitudinal clinical studies, methodologies available for the analysis of multivariate data with methods are relatively limited. Here, we present Consensus Clustering (CClust) a new computational method based on clustering time profiles and posterior identification correlation between clusters predictors. Subjects first clustered in groups according to response variable temporal profile, using robust consensus-based strategy. To discover which remaining variables associated resulting...
Transplantation is often the only way to treat a number of diseases leading organ failure. To overcome rejection towards transplanted (graft), immunosuppression therapies are used, which have considerable side-effects and expose patients opportunistic infections. The development model complement physician’s experience in specifying therapeutic regimens therefore desirable. present work proposes an Ordinary Differential Equations accounting for immune cell proliferation response sudden entry...
Focus on Youth Football and Alcohol (FYFA) is a European project (EC, 3rd Health Program, HP-PJ-2016) involving research institutions from Belgium, Finland, Italy, Poland, Slovenia the UK. The Istituto Superiore di Sanità (ISS), was leader of Work Package 5: "Review national policies practice in six Member States related to alcohol, young people, sport, marketing football." aim WP5 determine status quo practices reduce heavy episodic drinking alcohol sport at level. This work investigates...
Objective: to comparatively investigate – by means of computer simulations the economic cost and clinical outcomes five atypical oral antipsychotic agents (ziprasidone, olanzapina, risperidone, paliperidone aripiprazolo).Methods: a cyclical stochastic model representing patient evolution, taking into account main adverse reactions (akathisia, weight gain extra-pyramidal ARs), drug efficacy on psychosis stabilization probability relapse, was developed. Ten different scenarios were compared,...