A5070803873- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- Hemophilia Treatment and Research
- Tendon Structure and Treatment
- Proteoglycans and glycosaminoglycans research
- Orthopaedic implants and arthroplasty
- Sarcoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Bone Tumor Diagnosis and Treatments
- Total Knee Arthroplasty Outcomes
- Musculoskeletal pain and rehabilitation
- Epigenetics and DNA Methylation
- Blood Coagulation and Thrombosis Mechanisms
- Spinal Fractures and Fixation Techniques
- Bone health and treatments
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Hip and Femur Fractures
- Bone and Joint Diseases
- Pituitary Gland Disorders and Treatments
- Musculoskeletal Disorders and Rehabilitation
- Pelvic and Acetabular Injuries
- Cerebral Palsy and Movement Disorders
University of Naples Federico II
2016-2025
Federico II University Hospital
2003-2024
Osaka Metropolitan University
2023
Tokyo Metropolitan University
2023
Istituto Ortopedico Rizzoli
2017
Summary Magnetic resonance imaging ( MRI ) and ultrasonography US are increasingly used in haemophilia A HA to detect early joint changes. total of 40 clinically asymptomatic joints, never involved by bleeding events [“healthy joints” HJ )], were evaluated and, parallel, 20 young subjects with severe (22.45 ± 2.72 years old; no history arthritides, viral infections or inhibitors against factor VIII ). The same joints matched non‐haemophilic (no‐ (mean age 23.90 2.31 years, P = 0.078 vs....
Glucocorticoid-induced osteoporosis is the most frequent cause of secondary osteoporosis. Nevertheless, limited data are available on bone status in patients with endogenous cortisol excess. This study aimed at investigating role sex steroids and severity hypercortisolism mineral density (BMD) prevalence vertebral fractures female patients.Cross-sectional, case-control study.Seventy-one consecutive women were enrolled: 36 overt (26 ACTH-secreting pituitary adenoma 10 cortisol-secreting...
Spinal muscular atrophy (SMA) is a genetic disorder causing motor neuron loss and progressive muscle weakness, significantly affecting daily activities breathing in severe cases. While rehabilitation crucial component of SMA management, no standardised guidelines currently exist. This review synthesised physiotherapy respiratory interventions for patients based on comprehensive literature search from 1990 to 2024. Eighteen studies were analysed: eleven seven rehabilitation. Five approaches...
Oral supplementation of chondroitin sulfate (CS) and glucosamine (GlcN), symptomatic slow-acting molecules, is recommended by European Society for Clinical Economic Aspects Osteoporosis Osteoarthritis Musculoskeletal Diseases (ESCEO) other Union (EU) guidelines the restoration articular cartilage surface in patients affected osteoarthritis (OA). They are commercialized as pharmaceutical grade products food supplements combination with plant extracts hyaluronic acid, methylsulfonylmethane,...
High molecular weight hyaluronan (H-HA) has a pivotal role in the maintenance of normal functions synovial fluid and structure articular joint, but it been shown that its concentration is reduced patients affected by degenerative cartilage diseases, such as osteoarthritis (OA). The aim this study was to investigate anti-inflammatory effects properties hybrid cooperative complexes based on high low (HCC) compared H-HA human primary cells derived pathological joints. In addition, rheological...
Knee osteoarthritis (KOA) is a progressive and multifactorial disease that leads to joint pain, muscle weakness, physical disability, decreased quality of life. In KOA, the quantity hyaluronic acid (HA) molecular weight (MW) are decreased, leading pain due increased wear knee articular cartilage. Arthrogenic inhibition, which usually found in patients with associated inflammation, swelling, also causing atrophy, primarily anterior thigh muscles, hindering rehabilitation process. The aim our...
Abstract Several studies suggest that inflammation has a pivotal role during the progression of osteoarthritis (OA) and cytokines have been identified as main process mediators. This study aimed to explore ability modulate OA pro‐inflammatory biomarkers novel gels (H‐HA/BC) based on high molecular weight hyaluronan (H‐HA) unsulfated biotechnological chondroitin (BC). For first time, BC was tested also in combination with H‐HA human primary cells isolated from pathological knee joints....
Since the initial definition of acromegaly over 100 yr ago, extraordinary efforts have been made to control GH levels and pituitary tumor. Criteria cure evolving constantly all previous statements should be revised according modern criteria disease control. Arthropathy is undoubtedly most important cause morbidity functional disability acromegaly, bone alterations are highly characteristic this syndrome. They involve theoretically bones and, particularly, appendicular axial skeleton....
After the first Italian case of Covid-19, Government imposed complete closure all areas involved by spread virus to contain transmissions. There was a massive reorganization Hospitals, stop elective activities and convertion many hospitals in "Covid Centers''. AITOG (Associazione Italiana Traumatologia e Ortopedia Geriatrica) conducted retrospective study on proximal femur fractures surgeries that occurred this period, find out whether pandemic correlated lockdown somehow changed incidence...
BACKGROUND: Rotator cuff tendinopathy (RCTe) is the most common cause of pain and shoulder dysfunction. Numerous clinical studies have demonstrated therapeutic capacity exogenous peritendinous hyaluronic acid (HA), effectiveness extracorporeal shockwaves therapy (ESWT) in reducing pain. The aim this study was to evaluate added effects HA treatment plus ESWT (E-g) or alone (SC-g), focusing on reduction self-reported disability patients with RCTe.METHODS: Monocentric, randomized open-label...
Knee osteoarthritis (KOA) is a progressive and multifactorial disease that leads to joint pain, muscle weakness, physical disability, decreased quality of life. In KOA, hyaluronic acid (HA) quantity molecular weight (MW) are decreased, leading pain due increased wear the knee articular cartilage. Arthrogenic inhibition, which usually found in patients with associated inflammation, swelling, also causing atrophy, primarily anterior thigh muscles, hindering rehabilitation process. The aim our...
The aim of the study was to identify main aspects concerning appropriateness and efficacy Spa therapy for musculoskeletal pathologies.A committee 8 experts from Italian universities, public hospitals, territorial services, research institutes patient associations set up. Clinicians medical centers specialized in rheumatology, rehabilitation thermal medicine took part a Delphi process aimed at obtaining consensus statements among participants.Large obtained grouped under following themes:...