A5014280534- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Nuclear Receptors and Signaling
- Cholesterol and Lipid Metabolism
- Amyotrophic Lateral Sclerosis Research
- Nerve injury and regeneration
- Influenza Virus Research Studies
- Neurotransmitter Receptor Influence on Behavior
- Phytochemistry and Biological Activities
- Genetic Neurodegenerative Diseases
- Drug Transport and Resistance Mechanisms
- Reconstructive Surgery and Microvascular Techniques
- Cell Image Analysis Techniques
- Infectious Diseases and Tuberculosis
- Neurological diseases and metabolism
- Respiratory viral infections research
- Pharmacological Receptor Mechanisms and Effects
- Cellular transport and secretion
- RNA Research and Splicing
UNSW Sydney
2011-2025
The University of Sydney
2017-2025
Research Network (United States)
2024-2025
Hebei Medical University
2025
Collaborative Research Group
2024
BM-Science
2024
Guizhou Normal University
2021-2024
University of California, San Francisco
2024
Tianjin Medical University General Hospital
2024
Beijing Chest Hospital
2012-2023
Pitching cGAMP as a vaccine strategy One to address the variable effectiveness of many influenza vaccines is induce antiviral resident memory T cells, which can mediate cross-protection against multiple substrains (heterosubtypic immunity). Unfortunately, such typically use attenuated active viruses, may be unsafe for certain populations. Wang et al. report using an inactivated virus that effectively induced heterosubtypic immunity in both mice and ferrets (see Perspective by Herold Sander)....
Inflammation is likely a key contributor to the pathogenesis of Parkinson's disease (PD), progressively debilitating neurodegenerative that accompanied by pathological accumulation α-synuclein protein in staged manner through brain. What leads PD and how this relates inflammatory pathways, however, not entirely clear. Toll-like receptor (TLR) signaling major pathway mediating inflammation and, particular, TLR2 increasingly being implicated PD. We have, therefore, examined expression...
This research is responding to the latest sustainable development policy for residential housing in Australia, which mandates a minimum R6.0 roof insulation and requirement of reporting embodied carbon footprint new build houses before obtaining approval. The thermal resistance (R-value) results thicker material be used, inevitably increases total carbon. condition has drawn need an optimised design balance with required performance. In this paper, multi-objective, mixed-integer, non-linear...
Abstract Background Parkinson's disease (PD) is the most common neurodegenerative movement disease. Human endogenous retroviruses (HERVs) are proviral remnants of ancient retroviral infection germ cells that now constitute about 8% human genome. Under certain conditions, HERV genes activated and partake in process. However, virtually nothing known pathological relationship, if any, between PD. Objective The objectives this study were to unravel relationship retrovirus K (HERV‐K) PD,...
Article29 March 2018Open Access Transparent process Alpha-synuclein aggregates activate calcium pump SERCA leading to dysregulation Cristine Betzer orcid.org/0000-0001-5429-3548 Danish Research Institute of Translational Neuroscience – DANDRITE, Aarhus University, Aarhus, Denmark Department Biomedicine, Search for more papers by this author Louise Berkhoudt Lassen Anders Olsen Molecular Biology and Genetics, Rikke Hahn Kofoed Lasse Reimer Emil Gregersen Jin Zheng Tito Calì Biomedical...
Extensively drug-resistant tuberculosis (XDR-TB) is a deadly form of TB that can be incurable due to its extreme drug resistance. In this study, we aimed explore the in vitro susceptibility bedaquiline (BDQ), delamanid (DMD), linezolid (LZD), clofazimine (CLO), moxifloxacin (MFX), and gatifloxacin (GAT) 90 XDR-TB strains isolated from patients China. We also describe genetic characteristics isolates with acquired Resistance MFX, GAT, LZD, CLO, DMD, BDQ was found 82 (91.1%), 76 (84.4%), 5...
The N-methyl-D-aspartate receptor (NMDAR) is a Na(+) and Ca(2+) permeable ionotropic glutamate that activated by the coagonists glycine glutamate. NMDARs are critical to synaptic signaling plasticity, their dysfunction has been implicated in number of neurological disorders, including schizophrenia, depression, Alzheimer's disease. Herein we describe discovery potent GluN2A-selective NMDAR positive allosteric modulators (PAMs) starting from high-throughput screening hit. Using...
The heterogeneity of protein-rich inclusions and its significance in neurodegeneration is poorly understood. Standard patient-derived iPSC models develop neither reproducibly nor a reasonable time frame. Here, we developed screenable "inclusionopathy" utilizing piggyBac or targeted transgenes to rapidly induce CNS cells that express aggregation-prone proteins at brain-like levels. Inclusions their effects on cell survival were trackable single-inclusion resolution. Exemplar cortical neuron...
G-protein-regulated inward-rectifier potassium channel 2 (GIRK2) is reported to be expressed only within certain dopamine neurons of the substantia nigra (SN), although very limited data are available in humans. We examined localization GIRK2 SN and adjacent ventral tegmental area (VTA) humans mice by using either neuromelanin pigment or immunolabeling with tyrosine hydroxylase (TH) calbindin. immunoreactivity was found nearly every human pigmented neuron mouse TH-immunoreactive both VTA,...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia and abnormal deposits of aggregated amyloid-β in the brain. Recent genome-wide association studies have revealed that ABCA7 strongly associated with AD. In vitro evidence suggests role related to phagocytic activity. Deletion mouse model AD exacerbates cerebral plaque load. However, biological brain pathogenesis unknown. We show highly expressed microglia when monocytes are differentiated into macrophages....
Parkinson's disease (PD) is a movement disorder characterized by the early loss of nigrostriatal dopaminergic pathways producing significant network changes impacting motor coordination. Recently three stages PD have been proposed (a silent period when begins, prodromal with subtle focal manifestations, and clinical PD) evidence that cortex abnormalities occur to produce PD[8]. We directly assess structural in primary corticospinal tract using parallel analyses longitudinal cross-sectional...
Abstract Lipid peroxidation is a process of oxidative degradation cellular lipids that increasingly recognized as an important factor in the pathogenesis neurodegenerative diseases. We were therefore interested manifestation lipid synucleinopathies, group diseases characterized by central pathology α-synuclein aggregates, including Parkinson’s disease, multiple system atrophy, dementia with Lewy bodies and Alzheimer’s disease bodies. assessed products, aldehydes, amygdala, common...
Human endogenous retroviruses (HERVs) are DNA transposable elements that have integrated into the human genome via an ancestral germline infection. The potential importance of HERVs is underscored by fact they comprise approximately 8% genome. been implicated in pathogenesis neurodegenerative diseases, a group CNS diseases characterized progressive loss structure and function neurons, resulting cell death multiple physiological dysfunctions. Much evidence indicates initiators or drivers...
Abstract Parkinson’s disease (PD) is a chronic neurodegenerative disorder that affects the motor system. Increasing evidence indicates lysosomal dysfunction pivotal in pathogenesis of PD, typically characterized by dysregulation sphingolipids lysosomes. ATP-binding cassette subfamily A member 5 (ABCA5) transporter mediates removal excess sphingomyelin from We therefore investigated whether expression levels ABCA5 are associated with and α-synuclein pathology PD. Firstly, we undertook...
Brain cholesterol homeostasis is regulated by a group of proteins called ATP-binding cassette subfamily A (ABCA) transporters. Certain ABCA transporters regulate amyloid-β protein precursor (AβPP) processing to generate peptides (Aβ) and are associated with an increased risk for late-onset Alzheimer's disease (AD). ABCA5 little-known member the no known function. In this study we undertook comprehensive analysis expression in human mouse brains. We explored potential role AβPP AD pathology....
Pathology in the noradrenergic A6 locus coeruleus has not been compared with more rostral dopaminergic A9 substantia nigra and A10 ventral tegmental area, cholinergic Ch4 basal nucleus Ch1/2 septal regions same cases of Parkinson's disease (PD).To determine whether there is a gradient caudal to cell loss PD.Postmortem brains were collected from longitudinally followed donors PD (n = 14) aged-matched healthy 13), six restricted brainstem Lewy pathology (RLP), fixed formalin serial tissue...