A5103170922- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Surgical Simulation and Training
- Simulation-Based Education in Healthcare
- Anatomy and Medical Technology
- Enhanced Recovery After Surgery
- 14-3-3 protein interactions
- Reproductive Biology and Fertility
- Cancer Immunotherapy and Biomarkers
- Gynecological conditions and treatments
- Anesthesia and Pain Management
- BRCA gene mutations in cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Uterine Myomas and Treatments
- Intestinal and Peritoneal Adhesions
- Ethics in Clinical Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer and Skin Lesions
- Cancer Risks and Factors
- Augmented Reality Applications
- MRI in cancer diagnosis
- Sperm and Testicular Function
- Economic and Financial Impacts of Cancer
- Blood Coagulation and Thrombosis Mechanisms
- Genital Health and Disease
Memorial Sloan Kettering Cancer Center
2022-2024
University of South Florida
2019-2023
Kettering University
2023
Moffitt Cancer Center
2022
Florida College
2020
Albert Einstein College of Medicine
2019
Montefiore Medical Center
2019
Society of Thoracic Surgeons
2019
New York University
2016-2018
Columbia University Irving Medical Center
2018
Introduction Ovarian cancer recurs in most High Grade Serous Cancer (HGSOC) patients, including initial responders, after standard of care. To improve patient survival, we need to identify and understand the factors contributing early or late recurrence therapeutically target these mechanisms. We hypothesized that HGSOC, response chemotherapy is associated with a specific gene expression signature determined by tumor microenvironment. In this study, sought determine differences immune...
Objectives The use of simulation-based education to train surgeons is widely accepted. Although many authors describe the an Objective Skills Assessment Test (OSAT) assess performance various surgical procedures, there a paucity research on this modality evaluate vaginal surgery skills. We created hysterectomy procedure-specific checklist (PSC) complete OSAT (which composed PSC and global rating scale [GRS]). primary objective study novel evaluation strategy for using combining GRS. Methods...
BACKGROUND: With the new requirement for Fundamentals of Laparoscopic Surgery certification among graduating obstetrics and gynecology residents, there has been an increased interest in simulation training. The curriculum uses a commercial laparoscopic box trainer to practice assess skills. We created low-cost, space-efficient, portable versatile training platform that allows breakdown complex tasks, we studied its user acceptability. METHOD: A rectangular piece pine wood purchased at...
Combination therapy of lenvatinib, a multitargeted tyrosine kinase inhibitor (TKI), plus pembrolizumab, monoclonal antibody targeting programmed death receptor 1 (PD-1), was recently approved by the Food and Drug Administration for advanced endometrial cancer. This case series highlights three patients with serous carcinoma who experienced disease stabilization or slow progression on lenvatinib pembrolizumab followed rapid symptomatic growth after discontinuation, subsequent repeated...
• Management of platinum refractory ovarian cancer is challenging. Extensive venous thromboembolism precludes anti-angiogenic combination chemotherapy. Weekly paclitaxel and immune-checkpoint inhibitor provides a durable tumor control option.
BACKGROUND: Hysterectomies are the most common benign gynecologic surgical procedures performed in United States. Currently, there no tissue models that exist to teach trainees techniques for colpotomy during laparoscopic hysterectomy. To address this educational gap, we have created a model using porcine stomach attached uterine manipulator. METHODS: A segment of is secured onto manipulator simulate cervicovaginal junction. uterus with craft materials and reused subsequent sessions placed...
This study aims to evaluate the feasibility and safety of planned postoperative day 1 discharge (PPOD1) among patients who undergo laparotomy (XL) in department gynecology oncology utilizing a modified enhanced recovery after surgery (ERAS) protocol including opioid-sparing anesthesia (OSA) defined criteria.Patients undergoing XL minimally invasive (MIS) were enrolled this prospective, observational cohort departmental implementation ERAS protocol. The primary outcome was quality life (QoL)...
<h3>Introduction/Background</h3> To identify the anatomic distribution of endometrial cancer recurrences among different molecular subtypes and evaluate prognostic significance in recurrent setting. <h3>Methodology</h3> All patients with who had their initial staging surgery performed at our institution between 2014 2023 a biopsy-proven recurrence subtyping primary tumor were included study. Sites determined by clinical imaging review. <h3>Results</h3> A total 186 met inclusion criteria...
To develop a pre-operative tool to estimate the risk of peri-operative packed red blood cell transfusion in primary debulking surgery. We retrospectively reviewed an institutional database identify patients who underwent surgery for ovarian cancer at single center between January 1, 2001 and May 31, 2019. Receiver operating characteristic curve area under receiver (AUC) were calculated. Five-fold cross-validation was applied multivariate model. Significant variables assigned 'BLOODS' (BLood...
In this case, we discuss emergent small bowel resection and reanastomosis for a closed loop obstruction in the setting of recent bevacizumab exposure. Bevacizumab is humanized monoclonal antibody that binds to vascular endothelial growth factor, inhibiting angiogenesis, decreasing tissue healing capacity, therefore recommendation avoid administration within 28 days pre- postsurgery. Here We review available literature regarding complication rates challanges management counseling with limited...
Abstract Introduction: Endometrial carcinomas (ECs) of no-specific molecular profile (NSMP-EC) are a large and heterogenous group tumors. These cancers, in particular endometrioid carcinomas, thought to be dependent on or benefit from estrogen receptor (ER) signaling. In this study, we sought determine the sources ER signaling patients with NSMP-EC. Methods: We compiled retrospective database EC who received their primary treatment at our institution 2014 2022, had ECs NSMP based surrogate...
<h3>Introduction</h3> To further subclassify copy number-low endometrial carcinomas (CNL-EC) based on immunohistochemistry (IHC) with prognostic implications. <h3>Methods</h3> We compiled EC patients who received their primary treatment at our institution from 2014 to 2022, and had CNL-EC a surrogate of The Cancer Genome Atlas (TCGA) molecular subtype. Estrogen receptor (ER) PTEN IHC was performed. <h3>Results</h3> A total 104 were included. Eighty eight (84.6%) ER positive by IHC, 86 88...
We sought to investigate the safety and feasibility of therapeutic anticoagulation for newly diagnosed venous thromboembolism among women who undergo neoadjuvant chemotherapy treatment advanced ovarian cancer.
INTRODUCTION: One of the most common causes infertility is diminished ovarian reserve (DOR). AMH plays a role in determining and levels <1.05 ng/mL associated with DOR. Young IVF population even DOR have modest clinical outcome, however information on stimulation regimen limited. The aim this study was to evaluate gonadotropin dose required young patients low achieve optimal response. METHODS: A retrospective cohort based SART database between 2012–2016. included 23,001 fresh autologous...
e18067 Background: Concern for toxicities in obese ovarian cancer patients may limit weight-based chemotherapy dosing, which has been associated with poor survival. We sought to evaluate the impact of obesity on treatment and outcomes by race/ethnicity at a National Cancer Institute (NCI)-designated Comprehensive Center (CCC). Methods: 66 minority (non-Hispanic black, Hispanic) epithelial diagnosed 2006 treated frontline were frequency matched two non-Hispanic white (NHW) 5-year age group...
e13576 Background: Genetic testing has revolutionized the care of ovarian cancer, providing a potential for targeted therapies and cancer prevention through cascade testing. Previous historical control genetic rate 28.5% at our institution, this initiated multilevel intervention to improve guideline concordant care. The main objective study is descriptive analysis patterns with implementation genetics tumor board (GTB) an NCI comprehensive center (CCC). Methods: All gynecologic oncology...