A5093743150- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Pharmaceutical studies and practices
- Effects and risks of endocrine disrupting chemicals
- Neurological disorders and treatments
Northeastern University
2024-2025
Gladstone Institutes
2023-2025
Research Network (United States)
2024-2025
University of California, San Francisco
2024
The University of Sydney
2024
Parkinson’s disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but pathophysiological mechanisms that precede and drive their remain unknown. The activity DA neurons likely altered in PD, we understand little about if or how chronic changes may contribute to degeneration. To address this question, developed a chemogenetic (DREADD) mouse model chronically increase neuron activity, confirmed using ex vivo electrophysiology. Chronic hyperactivation...
Pavlovian fear conditioning is a widely used tool that models associative learning in rodents. For decades the field has predominantly male rodents and focused on sole conditioned response: freezing. However, recent work from our lab others identified darting as female-biased response, characterized by an escape-like movement across chamber. It also accompanied behavioral phenotype: Darters reliably show decreased freezing compared to Non-darters males reach higher velocities response foot...
Abstract Parkinson’s disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but pathophysiological mechanisms that precede and drive their remain unknown. The activity DA neurons likely altered in PD, we understand little about if or how chronic changes may contribute to degeneration. To address this question, developed a chemogenetic (DREADD) mouse model chronically increase neuron activity, confirmed using ex vivo electrophysiology. Chronic...
Parkinson’s disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but pathophysiological mechanisms that precede and drive their remain unknown. The activity DA neurons likely altered in PD, we understand little about if or how chronic changes may contribute to degeneration. To address this question, developed a chemogenetic (DREADD) mouse model chronically increase neuron activity, confirmed using ex vivo electrophysiology. Chronic hyperactivation...
Parkinson’s disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but pathophysiological mechanisms that precede and drive their remain unknown. The activity DA neurons likely altered in PD, we understand little about if or how chronic changes may contribute to degeneration. To address this question, developed a chemogenetic (DREADD) mouse model chronically increase neuron activity, confirmed using ex vivo electrophysiology. Chronic hyperactivation...
Chemogenetic models utilize the consumption of clozapine N-oxide (CNO) to activate Designer Receptors Activated Only by Drugs (DREADDs) in order modulate neuronal activity. This protocol describes preparation a CNO solution for mice, as well daily monitoring water intake.