A5065919550- Renal Diseases and Glomerulopathies
- Cell Adhesion Molecules Research
- Vasculitis and related conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Organ Donation and Transplantation
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Platelet Disorders and Treatments
- Biomedical Research and Pathophysiology
- Genetic and Kidney Cyst Diseases
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Blood Pressure and Hypertension Studies
- Medical History and Innovations
- Monoclonal and Polyclonal Antibodies Research
- Kidney Stones and Urolithiasis Treatments
- Electrolyte and hormonal disorders
- Systemic Lupus Erythematosus Research
- Adolescent and Pediatric Healthcare
- History of Medicine Studies
University of Edinburgh
2015-2025
Centre for Inflammation Research
2003-2025
Medical Research Council
1992-2024
Universities UK
2023-2024
Edinburgh Royal Infirmary
2010-2023
Chelsea and Westminster Hospital NHS Foundation Trust
2017-2023
Middlesex University
2012-2020
The Ohio State University
2005-2017
Chelsea and Westminster Hospital
2015
Kidney Research UK
2005-2012
Anti-glomerular basement membrane (GBM) antibody disease is an autoantibody-mediated disorder that usually presents as rapidly progressive glomerulonephritis, often with pulmonary hemorrhage (the Goodpasture syndrome). It reported patients severe renal failure do not generally recover function.To examine the long-term outcome of anti-GBM disease.Retrospective review treated for confirmed over 25 years.A tertiary referral center in United Kingdom.71 disease.All received plasma exchange,...
Background IgA nephropathy can progress to kidney failure, and risk assessment soon after diagnosis has advantages both for clinical management the development of new therapeutics. We present relationships among proteinuria, eGFR slope, lifetime risks failure. Methods The cohort (2299 adults 140 children) UK National Registry Rare Kidney Diseases (RaDaR) was analyzed. Patients enrolled had a biopsy-proven plus proteinuria >0.5 g/d or <60 ml/min per 1.73 m 2 . Incident prevalent...
To characterize the autoantigen of Goodpasture's (anti-glomerular basement membrane) disease, a molecule 26-kD reactive with autoantibodies from patients' sera was purified collagenase digests sheep glomerular membrane. Short internal amino acid sequences were obtained after tryptic or cyanogen bromide cleavage, and used to deduce redundant oligonucleotides for use in polymerase chain reaction on cDNA derived renal cortex. Molecules 175 bp amplified found come two sequences. One identical...
Change of direction speed (CODS) is often considered a main determinant successful performance in many team sports and routinely measured using field-based tests. However, controversy regarding test selection still exists based upon the reliability specificity The purpose this study was to determine compare reliability, factorial validity, interrelationships five frequently used CODS tests (Illinois, L-Run, Pro-Agility, T-test, 505). Forty-four physical education students (male n = 24;...
Human papillomavirus (HPV) infection causes cervical cancer and premalignant dysplasia. Type-specific HPV prevalence data provide a basis for assessing the impact of vaccination programmes on cytology. We report high-risk (HR-HPV) type-specific in relation to cytology 24 510 women (age range: 20–64; mean age 40.2 years) recruited into ARTISTIC trial, which is being conducted within routine NHS Cervical Screening Programme Greater Manchester. The most common HR-HPV types were HPV16, 18, 31,...
Background and objectives Minimal change disease is an important cause of nephrotic syndrome in adults. Corticosteroids are first-line therapy for minimal disease, but a prolonged course treatment often required relapse rates high. Patients with therefore exposed to high cumulative corticosteroid doses at risk associated adverse effects. This study investigated whether tacrolimus monotherapy without corticosteroids would be effective the de novo disease. Design, setting, participants, &...
In 1927 Arthur Cecil Alport, a South African physician, described British family with an inherited form of kidney disease that affected males more severely than females and was sometimes associated hearing loss. 1961, the eponymous name Alport syndrome adopted. late twentieth century three genes responsible for were discovered: COL4A3, COL4A4, COL4A5 encoding α3, α4, α5 polypeptide chains type IV collagen, respectively. These assemble to heterotrimers collagen in glomerular basement...
Background: Online access to all or part of their health records is widely demanded by patients and, where provided in form patient portals, has been substantially used at least subgroups patients, particularly those with chronic disease. However, little reported regarding the longer-term use patient-accessible electronic record services, which important allocating resources. Renal PatientView (RPV) an established system that gives kidney disease live test results and information about...
Alport syndrome (AS) is a genetic disease characterized by haematuric glomerulopathy variably associated with hearing loss and anterior lenticonus. It caused mutations in the COL4A3, COL4A4 or COL4A5 genes encoding α3α4α5(IV) collagen heterotrimer. AS rare, but it accounts for >1% of patients receiving renal replacement therapy. Angiotensin-converting enzyme inhibition slows, does not stop, progression to failure; therefore, there an urgent requirement expand intensify research towards...
Alport syndrome, historically referred to as hereditary glomerulonephritis with sensorineural deafness and anterior lenticonus, is a genetic disease of collagen α3α4α5(IV) resulting in renal failure. The heterotrimer forms network that major component the kidney glomerular basement membrane (GBM) membranes cochlea eye. estimated affect 1 5000–10,000 individuals, caused by mutations any one three genes encode α chain components heterotrimer: COL4A3, COL4A4, COL4A5. Although...
Background: The UK Registry of Rare Kidney Diseases (RaDaR) Idiopathic Nephrotic Syndrome cohort includes adults and children with genetic nephrotic syndrome, Focal Segmental Glomerulosclerosis (FSGS) minimal change disease. This study examines long-term patient outcomes as a function kidney biopsy diagnosis proteinuria control. Methods: 2467 1599 were followed to establish including eGFR slope survival by diagnosis, analysed from disease onset for FSGS Enrollment began in 2010, follow-up...
Increasingly, patient-reported outcome measures (PROMs) are used to monitor chronic kidney disease (CKD) symptoms in routine clinical practice. However, such symptom measurement currently requires completion of multiple, often lengthy, PROMs, which may lead questionnaire fatigue, lower levels completion, and missing data. Moreover, many CKD-specific PROMs lack evidence important properties few were developed using contemporary psychometric methods. The study objective was develop validate a...
Autoreactive T cells in patients with Goodpasture's disease are specific for epitopes the Goodpasture antigen (the NC1 domain of alpha3 chain type IV collagen) that rapidly destroyed during processing to a degree diminishes their presentation cells. We hypothesized patients' autoreactive exist because prevents self-epitopes they recognize, circumventing tolerance mechanisms. predicted these peptides should also healthy individuals, albeit at low frequency and an unprimed state. obtained...
Abstract Background Access to medical records on the Internet has been reported be acceptable and popular with patients, although most published evaluations have of primary care or office-based practice. We tested feasibility acceptability making unscreened results data from a complex chronic disease pathway (renal medicine) available patients over in project involving more than half renal units UK. Methods Content presentation Renal PatientView (RPV) system was developed patient groups. It...
Objectives The aims of this study were to assess the feasibility simultaneous testing for blood‐borne viruses ( BBV ), HIV , hepatitis C HCV ) and B HBV in Emergency Department ED ascertain seroprevalence these three setting. Methods A pilot program was undertaken as part routine clinical care . All attendees aged between 16 65 years old who able consent tested over a 55 week period on an opt out basis. Patients with positive test results linked services. Interventions aimed at improving...
Alport syndrome is caused by mutations in the genes COL4A3, COL4A4 or COL4A5 and characterised progressive glomerular disease, sensorineural hearing loss ocular defects. Occurring less than 1:5000, a rare genetic disorder but still accounts for > 1% of prevalent population receiving renal replacement therapy. There also increasing awareness about risk chronic kidney disease individuals with heterozygous genes. The mainstay current therapy use angiotensin-converting enzyme inhibitors...