A5087616615- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
- Lower Extremity Biomechanics and Pathologies
- Bone fractures and treatments
- Cancer-related molecular mechanisms research
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- TGF-β signaling in diseases
- Pain Management and Opioid Use
- dental development and anomalies
- Bone and Joint Diseases
- Periodontal Regeneration and Treatments
- Bone health and treatments
- Musculoskeletal synovial abnormalities and treatments
- Shoulder and Clavicle Injuries
- Orthopedic Surgery and Rehabilitation
- Foot and Ankle Surgery
- Adipose Tissue and Metabolism
- Pain Mechanisms and Treatments
- Bone and Dental Protein Studies
- Exercise and Physiological Responses
- Bone Tumor Diagnosis and Treatments
- Lipid metabolism and disorders
Cedars-Sinai Kerlan-Jobe Institute
2023-2024
Scottish Rite Freemasonry
2024
Cedars-Sinai Medical Center
2024
University of Minnesota
2018-2022
Karolinska Institutet
2011-2022
Penn State Milton S. Hershey Medical Center
2020-2021
Twin Cities Orthopedics
2021
Geisinger Medical Center
2020
National Taiwan University
2018
Karolinska University Hospital
2011-2015
In the growth plate, stem-like cells in resting zone differentiate into rapidly dividing chondrocytes of proliferative and then terminally non-dividing hypertrophic zone. To explore molecular switches responsible for this two-step differentiation program, we developed a microdissection method to isolate RNA from (RZ), (PZ), zones (HZ) 7-day-old male rats. Expression approximately 29,000 genes was analyzed by microarray selected verified real-time PCR. The analysis identified whose expression...
In embryonic growth cartilage, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP) participate in a negative feedback loop that regulates chondrocyte differentiation. Postnatally, this region undergoes major structural functional changes. To explore the organization of Ihh–PTHrP system postnatal plate, we microdissected plates 7-day-old rats into their constituent zones assessed expression genes participating loop. Ihh , Patched 1, Smoothened, Gli1, Gli2, Gli3 Pthr1 were...
During the development of appendicular skeleton, cartilaginous templates undergo hypertrophic differentiation and remodels into bone, except for cartilage most adjacent to joint cavities where endochondral bone formation are prevented, chondrocytes instead form articular cartilage. The mechanisms that prevent have not been elucidated. To explore role synovial microenvironment in chondrocyte differentiation, osteochondral allografts consisting cartilage, epiphyseal growth plate from distal...
Articular and growth plate cartilage are discrete tissues but arise from a common cartilaginous condensation have comparable spatial architectures consisting of distinct layers chondrocytes. To investigate similarities differences between articular to explore transcriptional changes that occur during the onset their divergence, we performed manual microdissection 10-day-old rat proximal tibias, microarray analysis, bioinformatics, real-time PCR compare gene expression profiles in individual...
Orthopedic implant removal following open reduction internal fixation of a fracture is common procedure, especially in the foot and ankle. The purpose this study was to evaluate functional change after symptomatic implants ankle (ORIF) using Short Musculoskeletal Function Assessment (SMFA) outcome score. We hypothesized that would result improved outcomes.Retrospective review prospectively collected data on patients with closed between 2013 2016 performed. Inclusion criteria were skeletal...
During early bone formation, mesenchymal cells condense and then differentiate into collagen type II-expressing chondrocytes that make up the cartilaginous anlagen. This anlage becomes enclosed by perichondrium. The mechanisms which perichondrium forms are not known. purpose of this study was to determine whether epiphyseal can perichondrial cells. Novel markers were identified expression microarray microdissected rat growth plate cartilage. A dissection method allowed for removal...
Background: The gluteus minimus (GMin) and medius (GMed) are important dynamic stabilizers of the hip, but quantitative data on their biomechanical roles in stabilizing hip currently lacking. Purpose: To (1) establish a reproducible cadaveric model abductor complex (2) characterize effects loading GMin GMed extraneous femoral rotation distraction. Study Design: Controlled laboratory study. Methods: A total 10 hemipelvises were tested 4 muscle states: unloaded, loaded, (3) (4) both loaded....
Traditional management of moderate to severe stable slipped capital femoral epiphysis (SCFE) has been in situ fixation followed by reconstructive surgery if symptoms arise. This delayed approach may lead irreversible intra-articular damage the hip over time. The purpose this study was compare radiographic and clinical outcomes modified Dunn procedure (MDP) versus Imhauser osteotomy (DIO).
The long head biceps tendon is a common culprit of anterior shoulder pain and dysfunction that can be surgically treated with tenotomy or tenodesis. Many techniques exist for This article submits an arthroscopic technique using two loop-and-tack sutures knotless suture anchor to tenodese the in proximal bicipital groove situ. advantage this it maintains its native position by performing tenodesis before tenotomy. Most other attempt restore through approximation. transverse humeral ligament...
Purpose: Supracondylar humerus (SCH) fractures are the most common elbow fracture in children; however, they rarely occur as open injuries. Open associated with higher rates of infection, neurovascular injury, compartment syndrome, and nonunion. The purpose this study was to evaluate treatment outcomes SCH children. Methods: Between 2008 2015, four children (1%) had injuries among 420 treated for at a single center. mean patient age six years (range, eight years). Two patients...
Background Wound management associated with Gustilo grade IIIb open tibia fractures in children often requires muscle flaps, skin grafts, and amputations. The purpose of this study is to report the outcomes complications vacuum-assisted closure (VAC) treatment, as well discuss its role optimizing value when treating these injuries. Methods A retrospective review medical records imaging studies was performed from 2008-2015. Six pediatric patients managed VAC were identified. time frequency...