A5019907137- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Statistical Methods in Clinical Trials
- Radiation Therapy and Dosimetry
- Process Optimization and Integration
- Advanced Control Systems Optimization
- Cancer survivorship and care
- Digital Mental Health Interventions
- Cancer Treatment and Pharmacology
- Fault Detection and Control Systems
- Advanced X-ray and CT Imaging
- Biomedical Text Mining and Ontologies
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Radiative Heat Transfer Studies
- Cancer-related cognitive impairment studies
- Health and Medical Studies
- Manufacturing Process and Optimization
- Advanced Bandit Algorithms Research
- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Telemedicine and Telehealth Implementation
- Artificial Intelligence in Healthcare and Education
- Aortic Thrombus and Embolism
- Mathematical Biology Tumor Growth
Fraunhofer Institute for Industrial Mathematics
2008-2023
Gesellschaft zur Förderung angewandter Informatik
2021
Virtuelle Fabrik (Switzerland)
2017
Software (Spain)
2017
Fraunhofer Society
2007-2014
Hôpital Foch
2004-2007
Daimler (Germany)
2003-2005
Eppendorf (Germany)
2004
To compare fotemustine and dacarbazine (DTIC) in terms of overall response rate (ORR) as primary end-point survival, duration responses, time to progression, occurrence brain metastases (BM), assess safety quality life patients with disseminated cutaneous melanoma.Patients received either intravenous 100 mg/m2 weekly for 3 weeks or DTIC 250 mg/m2/d 5 consecutive days every 4 (two cycles). Nonprogressive a maintenance treatment (fotemustine days).Two hundred twenty-nine were randomly assigned...
Abstract Commercially available flow sheet simulators cannot perform optimization runs with more than one criterion. To overcome this problem, the simulator CHEMCAD is combined an external solver, and Excel VBA client used to arrange inter‐process communications. The resulting tool for multi‐criteria in chemical process engineering applied two separation problems. First, a dividing‐wall column as theoretical example test different starting points scalarization techniques. Second, significant...
In this work, a new approach for simultaneous steady state simulation and optimization of distillation-based flowsheets is presented. The process embedded in an problem with small number variables constraints. Hence, no specialized solvers are needed. Moreover, arbitrary specifications the form equalities or inequalities can be set formulation. This matches engineering demands usually much better than specifying given quantity fixed numbers. remaining distillation columns calculated from...
The objective of radiotherapy planning is to find a compromise between the contradictive goals delivering sufficiently high dose target volume while widely sparing critical structures. search for such requires computation several plans, which mathematically means solving optimization problems. In case intensity modulated (IMRT) these problems are large-scale, hence accumulated computational expense very high. adaptive clustering method presented in this paper overcomes difficulty. main idea...
According to Europe's Beating Cancer Plan, the number of cancer survivors is growing every year and now estimated at over 12 million in Europe. A main objective European Commission ensure that can enjoy a high quality life, underlining role digital technology eHealth apps tools achieve this.The this study development user-centered artificial intelligence system facilitate input integration patient-related biopsychosocial data improve posttreatment well-being, health outcomes examine...
The formulation of optimization problems in intensity-modulated radiotherapy (IMRT) planning comprises the choice various values such as function-specific parameters or constraint bounds. In current inverse programs that yield a single treatment plan for each optimization, it is often unclear how strongly these modeling affect resulting plan. This work investigates mathematical concepts elasticity and sensitivity to deal with this problem. An artificial case horse-shoe formed target...
Abstract Focused ultrasound therapy (FUS) is a modern and promising way for minimally invasive cancer treatment. Recent advances in treatment technology, bio‐physical models, numerical simulation methods have given rise to significant curative potential. However, clinical routine of FUS still features classical planning approaches, which widely fail exploiting this The structure problems strongly suggests interactive multi‐criteria decision‐making concepts order improve quality. This...
The formulation of intensity modulated radiation therapy (IMRT) planning aspects frequently uses the dose–volume histogram (DVH), whereas plan computations often happen in more desirable convex IMRT optimization framework. Inspired by a recent publication Zinchenko et al (2008 Phys. Med. Biol. 53 3231–50), this work addresses integration DVH-based into framework from general point view. It first provides basic mathematical requirements on evaluation functions order to support such an...
ZUSAMMENFASSUNG Depressive Störungen gehören zu den häufigsten psychischen Erkrankungen in Deutschland. Trotz umfassender Versorgungsstrukturen gelingt es im deutschen Gesundheitssystem häufig nicht, eine an Empfehlungen der Nationalen VersorgungsLeitlinie Depression orientierte Behandlung umzusetzen. Auch ist für Patienten herausfordernd, sich sektorisierten Versorgungssystem die erforderlichen Therapien selbst organisieren, was u. a. mit Unterschieden Gesundheitswissen, Bildungsstand aber...
Purpose: The aim of this paper is a first evaluation the performance new multi‐criteria optimization (MCO) tool developed for IMRT treatment planning Method and Materials: MCO‐tool computes set Pareto‐optimal plans by simultaneously minimizing dose indicators tumor targets considered organs at risk. For tumor, homogeneity in target maximized given, prescribed mean while relative deviations to upper equivalent uniform (EUD) limits are minimized exploration solution space done with visual...