A5083203553- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- CAR-T cell therapy research
- Complement system in diseases
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- COVID-19 Impact on Reproduction
Max Delbrück Center
2022-2024
Charité - Universitätsmedizin Berlin
2022-2024
Humboldt-Universität zu Berlin
2022-2023
Freie Universität Berlin
2022-2023
Abstract Diverse autoantibodies were suggested to contribute severe outcomes of COVID‐19, but their functional implications are largely unclear. ACE2, the SARS‐CoV‐2 receptor and a key regulator blood pressure, was described be one many targets in COVID‐19. ACE2 its soluble form (sACE2) is highly elevated critically ill patients, raising question whether sACE2:spike complexes induce reactivity. Screening 247 COVID‐19 we observed sACE2 anti‐ACE2 IgG that poorly correlated. Interestingly,...
Recombination of antibody genes in B cells can involve distant genomic loci and contribute a foreign antigen-binding element to form hybrid antibodies with broad reactivity for Plasmodium falciparum. So far, containing the extracellular domain LAIR1 LILRB1 receptors represent unique examples cross-chromosomal diversification. Here, we devise technique profile non-VDJ elements from transcripts. Independent preexposure donors malaria parasites, inserts were detected 80% individuals at...
The structure-based design of antigens holds promise for developing vaccines with higher efficacy and improved safety profiles. We postulate that abrogation host receptor interaction bears potential the improvement by preventing antigen-induced modification function as well displacement or masking immunogen. Antigen modifications may yet destroy epitopes crucial antibody neutralization. Here, we present a methodology integrates deep mutational scans to identify score SARS-CoV-2 binding...