A5100733229- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Ocular Infections and Treatments
- Orthopedic Surgery and Rehabilitation
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Vascular Malformations Diagnosis and Treatment
- Retinal and Macular Surgery
- Genetic factors in colorectal cancer
- Autoimmune and Inflammatory Disorders
- Cancer Treatment and Pharmacology
- Reconstructive Surgery and Microvascular Techniques
- Intraocular Surgery and Lenses
- Reconstructive Facial Surgery Techniques
- Ocular Disorders and Treatments
- Advanced Breast Cancer Therapies
- Intracerebral and Subarachnoid Hemorrhage Research
National Taiwan University
2006-2025
Changzhou University
2025
Taipei Veterans General Hospital
1992-2024
Anhui Polytechnic University
2023
Capital Medical University
2023
Soochow University
2023
Second Affiliated Hospital of Soochow University
2023
Fu Jen Catholic University
2021-2023
Beijing Tongren Hospital
2023
National Taiwan University Hospital
2009-2022
Abstract The spatial role of M1 and M2 tumor-associated macrophages (M1/M2 TAMs) in precision medicine remains unclear. EGFR TP53 are among the most frequently mutated genes lung adenocarcinoma. We characterized mutation status density M1/M2 TAMs within tumor islets stroma 117 adenocarcinomas using next-generation sequencing immunohistochemistry, respectively. Stromal were positively correlated with disease progression smoking history. In contrast, islet predominantly found tumors wild-type...
Myasthenia gravis (MG), an acquired autoimmune-related neuromuscular disorder that causes muscle weakness, presents with varying severity, including myasthenic crisis (MC). Although MC can cause significant morbidity and mortality, specialized neuro-intensive care produce a good long-term prognosis. Considering the outcomes of MG during hospitalization, it is critical to conduct risk assessments predict need for intensive care. Evidence valid tools screening patients are lacking. We used...
Purpose.: To compare the effects of early, mid, and late subconjunctival injection bevacizumab on corneal neovascularization (NV) conjunctivalization in a rabbit limbal insufficiency model. Methods.: Limbal was created surgically, injections 2.5 mg twice weekly for 1 month were started immediately (early group), week (mid after injury (late group). The epithelial alterations, stromal opacity, centricity, extent, PICS (percentage involved surface) NV evaluated. expression cytokeratins K3, K4,...
Purpose To evaluate the effects and underlying mechanisms of early late subconjunctival injection bevacizumab on inhibition corneal neovascularization (NV). Methods Corneal NV was induced by closed eye contact lens wear followed a silk suture tarsorrhaphy in rabbits. Weekly injections (5.0 mg) for 1 month were started immediately (early treatment group) or after induction with continuous (late group). The severity evaluated. Immunostaining used to intracorneal diffusion bevacizumab,...
A clinical review with an analysis of prognostic factors, including characteristics, histological classifications, presenting symptoms/signs and treatment modalities, was conducted in 67 patients primary malignant neoplasms the trachea who were seen at Veterans General Hospital-Taipei between 1979 1994. The incidence tracheal cancer 140 times less than lung during this period. Delayed diagnosis more 6 months after onset symptoms occurred one-third owing to lack specific indicative disease....
Palbociclib (PAL) is an effective anti-breast cancer drug, but its use has been partly restricted due to poor bioavailability (resulting from extremely low water solubility) and serious adverse reactions. In this study, two cocrystals of PAL with resorcinol (RES) or orcinol (ORC) were prepared by evaporation crystallization enhance their solubility. The characterized single crystal X-ray diffraction, Hirshfeld surface analysis, powder differential scanning calorimetry, thermogravimetric...
To determine the effects on corneal neovascularization (NV) and lipid deposition after subconjunctival injection of bevacizumab in patients who had NV associated with keratopathy.A case interventional study enrolled 18 (18 eyes) keratopathy. We gave monthly injections from 3 to 10 times during follow-up period according clinical response. evaluated centricity, extent, percentage involved surface (PICS) NV; density PICS deposition; best-corrected visual acuity before treatment. analyzed...
Rational design and virtual screening of novel inhibitors HIV reverse transcriptase associated ribonuclease H based on a combined molecular modeling study.
Myasthenia gravis (MG) is an autoimmune disorder that causes muscle weakness. Although the management well established, some patients are refractory and require prolonged hospitalization. Our study aimed to identify important factors predict duration of hospitalization in with MG by using machine learning methods. A total 21 were chosen for analyses. We retrospectively reviewed data who admitted hospital. Five methods, including stochastic gradient boosting (SGB), least absolute shrinkage...
Purpose: To report the in-vivo confocal microscopic findings of dendritiform cells in central corneal epithelial layer a case mixed bacterial keratitis associated with severe immunologic reaction. Design: Observational report. Methods: A 25-year-old male suffered from contact lens-related dense eccentric immune ring. In-vivo microscopy was performed to study different layers and peripheral cornea lesion fellow eye. Results: Several were found basal superficial eye, which also area ring...
Purpose: To compare the corneal epitheliotrophic capacity of different human blood-derived preparations, including cord blood serum (CBS), peripheral (PBS), and fresh frozen plasma (FFP) on bovine epithelial cells. Materials Methods: The concentrations growth factor, transforming factor β1, insulin-like 1, hyaluronic acid, fibronectin, albumin, glucose, calcium in derivatives were evaluated using enzyme-linked immunosorbent assay or biochemical methods. Cultivated cells incubated with...
We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines function at different hematopoietic stages also fluctuate during myelosuppression extent cytokine level fluctuations correlate severity. Fifteen participated study. Serum stem cell (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyte-macrophage CSF (GM-CSF)...
The purpose of this manuscript was to provide a better understanding patients with intralenticular foreign bodies (FBs) and also review the reported cases, including clinical presentation, diagnosis, management, visual outcome. A 50-year-old male referred our clinic suspected intraocular FB. Under slit-lamp examination, full-thickness corneal wound localized edema at temporal lower peri-limbal area revealed. Seidel test did not indicate any leakage. corresponding iris depigmented, but there...
Purpose: The aim of this study was to evaluate the feasibility storing anterior corneal buttons split from donor Descemet stripping automated endothelial keratoplasty (DSAEK) tissue for later use in tectonic lamellar patch grafting. Methods: Donor corneas DSAEK were into and posterior lamellae using a 350-μm depth microkeratome, remaining stored up 4 weeks at 4°C Optisol GS before grafting cornea sclera. Results: GS–preserved grafts successfully restored maintained corneoscleral integrity...
To evaluate the clinical effect of combined topical autologous serum eye drops (ASEs) and silicone hydrogel contact lens (CLs) for treatment corneal persistent epithelial defects (PEDs) after infectious ulcers.We conducted a retrospective chart review 12 patients with postinfectious PEDs who were unsuccessfully treated conventional medical management then 20% (v/v) ASEs CLs from July 1, 2011, to June 30, 2014. The ulcers all initially managed antibiotic until infiltrates resolved but lesions...
We retrospectively reviewed the chart records at Veterans General Hospital-Taipei for period between January 1985 and December 1994 to examine temporal relationship cancers of lung upper aerodigestive tract. A total 56 patients (54 males, 2 females) with histocytologically proven double primary cancers, either cancer or tract appearing first, were found. Squamous cell carcinoma was most frequent histologic type (squamous 57%, adenocarcinoma 27%, poorly differentiated 9%, small 7%). The...
It was the aim of this study to perform a review clinical features, treatments and outcomes patients with idiopathic sclerosing orbital inflammation (ISOI) in Taiwan.All histologically confirmed ISOI from 1995 2007 at National Taiwan University Hospital were included. We reviewed medical charts see presentation, treatment modalities, efficacy final status these patients.Six male 3 female ranging age 33 82 years The most common symptoms pain blurred vision (both 77.8%). Reduced visual acuity...