A5020927012- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Malaria Research and Control
- Animal Virus Infections Studies
- Invertebrate Immune Response Mechanisms
- Radioactive Decay and Measurement Techniques
- Chemistry and Stereochemistry Studies
- Mosquito-borne diseases and control
- T-cell and B-cell Immunology
- Escherichia coli research studies
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Complement system in diseases
- Topological and Geometric Data Analysis
- Philosophy, Science, and History
- Libraries and Information Services
- Drug Transport and Resistance Mechanisms
- Spectroscopy and Chemometric Analyses
- History and advancements in chemistry
University of Edinburgh
2024-2025
Wellcome Trust
2021
Kenya Medical Research Institute
2020-2021
Egerton University
2020-2021
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding infected erythrocytes to human cells and plays key role in parasite immune evasion malaria pathology. The increased availability genome sequence data has revolutionised the study PfEMP1 diversity across multiple P . isolates. However, making functional sense genomic relies on ability infer phenotype from gene sequence. For rosetting,...
Reducing malaria transmission has been a major pillar of control programmes and is considered crucial for achieving elimination. Gametocytes, the transmissible forms
Introduction Naturally acquired immune responses against antigens expressed on the surface of mature gametocytes develop in individuals living malaria-endemic areas. Evidence suggests that such anti-gametocyte immunity can block development parasite mosquito, thus playing a role interrupting transmission. A better comprehension naturally to these gametocyte aid transmission-blocking vaccines and improve our understanding human infectious reservoir. Methods Antigens had not previously been...
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding infected erythrocytes to human cells and plays key role in parasite immune evasion malaria pathology. The increased availability genome sequence data has revolutionised the ability study PfEMP1 diversity across multiple P. isolates. However, making functional sense genomic relies on infer phenotype from gene sequence. For rosetting,...
Malaria caused by Plasmodium falciparum remains a serious global public health challenge especially in Africa. Interventions that aim to reduce malaria transmission targeting the gametocyte reservoir are key elimination and/or eradication. However, factors associated with carriage have not been fully explored. Consequently, identifying predictors of infectious is fundamental campaign. We cultured P. NF54 gametocytes (to stage V) and prepared crude extract. Samples from total 687 participants...