A5091174658- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Cerebrovascular and genetic disorders
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
Ludwig-Maximilians-Universität München
2022-2025
Hippocampus-related cognitive deficits in working and verbal memory are frequent schizophrenia, hippocampal volume loss, particularly the cornu ammonis (CA) subregions, was shown by magnetic resonance imaging studies. However, underlying cellular alterations remain elusive. By using unbiased design-based stereology, we reported a reduction oligodendrocyte number CA4 schizophrenia of granular neurons dentate gyrus (DG). Here, aimed to replicate these findings an independent sample. We used...
Abstract Structural and functional abnormalities of the anterior cingulate cortex (ACC) have frequently been identified in schizophrenia. Alterations von Economo neurons (VENs), a class specialized projection neurons, found different neuropsychiatric disorders are also suspected To date, however, no definitive conclusions can be drawn about quantitative histologic changes ACC schizophrenia because lack rigorous, design-based stereologic studies. In present study, volume, total neuron number...
Alzheimer’s disease (AD) and vascular dementia (VaD) together contribute to almost 90% of all cases leading major health challenges our time with a substantial global socioeconomic burden. While in disease, the improved understanding Amyloid beta (Aß) mismetabolism tau hyperphosphorylation as pathophysiological hallmarks has led significant clinical breakthroughs, similar advances VaD are lacking. We thus highlight here importance shared pathomechanisms found AD VaD:...
Schizophrenia is a severe mental disorder with neurodevelopmental origin whose pathophysiological processes are poorly understood. Magnetic resonance imaging studies have shown structural alterations, such as volume loss in the temporal lobe, including hippocampus and amygdala, thalamus, frontal cortex, while other found reduced oligodendrocyte numbers hippocampal CA4 subregion dorsolateral prefrontal cortex. The decreased number of oligodendrocytes was reported to be related cognitive...
Alzheimer’s disease (AD) and vascular dementia (VaD) together contribute to almost 90% of all cases leading major health challenges our time with a substantial global socioeconomic burden. While in AD, the improved understanding Amyloid beta (Aß) mismetabolism tau hyperphosphorylation as pathophysiological hallmarks has led significant clinical breakthroughs, similar advances VaD are lacking. After comparing presentation, including risk factors, patterns, course diseases...