A5004279387- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Apelin-related biomedical research
- Stress Responses and Cortisol
- Signaling Pathways in Disease
- Hypothalamic control of reproductive hormones
- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Adipose Tissue and Metabolism
- Pharmacological Effects and Assays
- Pharmacological Effects of Natural Compounds
- Proteoglycans and glycosaminoglycans research
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Biochemical effects in animals
- Glycosylation and Glycoproteins Research
- Infant Health and Development
Instituto de Investigación Biomédica de Málaga
2015-2024
Universidad de Málaga
2014-2024
Karolinska Institutet
1998-2016
Extrasynaptic neurotransmission is an important short distance form of volume transmission (VT) and describes the extracellular diffusion transmitters modulators after synaptic spillover or extrasynaptic release in local circuit regions binding to activating mainly neuronal glial receptors neuroglial networks brain. Receptor-receptor interactions G protein-coupled receptor (GPCR) heteromers play a major role, on dendritic spines nerve terminals including glutamate synapses, integrative...
Galanin receptor (GalR) subtypes 1-3 linked to central galanin neurons may form heteromers with each other and types of G protein-coupled receptors in the nervous system (CNS). These be one molecular mechanism for peptides their N-terminal fragments (gal 1-15) modulate function different glia-neuronal networks CNS, especially emotional cardiovascular networks. GalR-5-HT1A likely exist antagonistic receptor-receptor interactions ascending midbrain raphe 5-HT neuron systems target regions....
Studies on serotonin-selective reuptake inhibitors have established that disturbances in the ascending 5-HT neuron systems and their receptor subtypes collateral networks to forebrain contribute etiology of major depression are targets for treatment. The therapeutic action is proven effectiveness, but mechanisms underlying effect still unclear. There many involved; some need be blocked (e.g., 5-HT2A, 5-HT3, 5-HT7), whereas others activated postjunctional 5-HT1A 5-HT4). These state-of-the-art...
Galanin (GAL) plays a role in mood regulation. In this study we analyzed the action of active N-terminal fragment [GAL(1–15)] anxiety- and depression-related behavioral tests rats. The effect GAL(1–15) was forced swimming test, tail suspension open field light/dark test. proximity GAL1 GAL2 receptors examined with ligation assay (PLA). We tested GAL involved effects receptor antagonist M871 an vivo model siRNA knockdown or were also studied cell line RN33B. induced strong depression-like...
Morphine is one of the most effective drugs used for pain management, but it also highly addictive. elicits acute and long-term adaptive changes at cellular molecular level in brain, which play a critical role development tolerance, dependence addiction. Previous studies indicated that dopamine D4 receptor (D4R) activation counteracts morphine-induced μ opioid (MOR) signaling striosomes caudate putamen (CPu), as well induction several Fos family transcription factors. Thus, has been...