A5047380116- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Biochemical and Molecular Research
- RNA modifications and cancer
- Toxin Mechanisms and Immunotoxins
- Insect symbiosis and bacterial influences
- Viral Infections and Immunology Research
- Endoplasmic Reticulum Stress and Disease
- Plant Virus Research Studies
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Cardiomyopathy and Myosin Studies
- Galectins and Cancer Biology
Institut Pasteur de Montevideo
2012-2024
Institut Pasteur
2013
Abstract Trypanosomes are eukaryotic, unicellular parasites, such as Trypanosoma brucei , which causes sleeping sickness, and cruzi Chagas disease. Genomes of these parasites comprise core regions species-specific disruptive that encode multigene families surface glycoproteins. Few transcriptional regulators have been identified in the role spatial organization genome gene expression is unclear. Here we mapped genome-wide chromatin interactions T. using chromosome conformation capture...
Chagasic chronic cardiomyopathy is one of the most frequent and severe manifestations Chagas Disease, caused by parasite Trypanosoma cruzi. The pathogenic biochemical mechanisms responsible for cardiac lesions remain not completely understood, although it clear that hypertrophy subsequent heart dilatation in part direct infection cardiomyocytes. In this work, we evaluated initial response human cardiomyocytes to T. cruzi infection. Immediately after infection, dramatically change their gene...
Introduction Trypanosoma cruzi , the causative agent of Chagas disease, can infect almost any nucleated cell in mammalian host. Although previous studies have described transcriptomic changes that occur host cells during parasite infection, understanding role post-transcriptional regulation this process is limited. MicroRNAs, a class short non-coding RNAs, are key players regulating gene expression at level, and their involvement host- T. interplay growing area research. However, to our...
Peroxiredoxins are abundant and ubiquitous proteins that participate in different cellular functions, such as oxidant detoxification, protein folding, intracellular signaling. Under conditions, peroxiredoxins can be secreted by parasites, promoting the induction of immune responses hosts. In this work, we demonstrated cytosolic tryparedoxin peroxidase Trypanosoma cruzi (cTXNPx) is epimastigotes trypomastigotes associated with extracellular vesicles also a vesicle-free protein. By confocal...