A5005515247- Dental materials and restorations
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Endodontics and Root Canal Treatments
- Dental Trauma and Treatments
- Cancer therapeutics and mechanisms
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Dental Radiography and Imaging
- Metabolomics and Mass Spectrometry Studies
- Advanced biosensing and bioanalysis techniques
- Lipid metabolism and biosynthesis
- Cancer-related Molecular Pathways
- Redox biology and oxidative stress
- Autophagy in Disease and Therapy
- Force Microscopy Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
Chi Mei Medical Center
2013-2025
National Sun Yat-sen University
2010
For rapid and unlimited cell growth proliferation, cancer cells require large quantities of nutrients. Many metabolic pathways nutrient uptake systems are frequently reprogrammed upregulated to meet the demand from cells, including for lipids. The lipids most adult normal mainly acquired circulatory system. Whether different adopt identical mechanisms ensure sufficient lipid supply, whether supply each other, remains unclear, was investigated in lung cells. Results showed that, despite...
The anti-oral cancer effects of santamarine (SAMA), a
Manoalide provides preferential antiproliferation of oral cancer but is non-cytotoxic to normal cells by modulating reactive oxygen species (ROS) and apoptosis. Although ROS interplays with endoplasmic reticulum (ER) stress apoptosis, the influence ER on manoalide-triggered apoptosis has not been reported. The role in manoalide-induced was assessed this study. induces a higher expansion aggresome accumulation than cells. Generally, manoalide differentially influences mRNA protein expressions...
Abstract Increased neddylation benefits the survival of several types cancer cells. The inhibition has potential to exert anticancer effects but is rarely assessed in oral This study aimed investigate antiproliferation a inhibitor MLN4924 (pevonedistat) for inhibited cell viability cells more than that normal (HGF‐1) with 100% viability, is, IC 50 values (CAL 27, OC‐2, and Ca9‐22) are 1.8, 1.4, 1.9 μM. caused apoptotic changes such as subG1 accumulation, activation annexin V, pancaspase,...
The unpredictable condition of cracked teeth warrants further investigation and clinical experiences. purpose this study was to collect record data on demographics, characteristics, different treatment modalities survival at 6-month, 1-year 2-year recalls. 77 from 65 patients were included. Data parameters, recall collected. Binomial, multinomial chi square tests used for statistical analysis. Most occurred in greater than 40 years old (p < 0.01). Cracked themselves most often molars...
Probe design is a critical parameter in successful DNA and RNA target detection. In this proof-of-concept study, we evaluated the single-base mismatch recognition power of surface immobilized self-assembled stem-loop hairpin oligonucleotide probes modified to contain locked nucleic acid residues (LNA-HP). The stiffness change conjunction with stem opening interfacial molecules before after hybridization led clear variations overall film thickness or miniaturized nanospot height, which could...
The purpose of this report is to present conservative treatment for two immature premolars with apical periodontitis. A triple antibiotic paste was used disinfect the root canal systems revascularization. In both cases, residual vital pulp tissue noted in system after opening each premolar. canals cases were irrigated copious sodium hypochlorite solution and medicated a consisting ciprofloxacin, metronidazole, minocycline. teeth sealed mineral trioxide aggregate restored composite resin....
Abstract Antioral cancer drugs need a greater antiproliferative impact on than normal cells. Demethoxymurrapanine (DEMU) inhibits proliferation in several cells, but an in‐depth investigation was necessary. This study evaluated the proliferation‐modulating effects of DEMU, focusing oral and DEMU (0, 2, 3, 4 μg/mL) at 48 h treatments inhibited cells (the cell viability (%) for Ca9‐22 100.0 ± 2.2, 75.4 5.6, 26.0 3.8, 15.4 1.4, CAL 27 9.4, 77.2 5.9, 57.4 10.7, 27.1 1.1) more strongly that S‐G...