A5103327378- Glutathione Transferases and Polymorphisms
- Asthma and respiratory diseases
- Human Health and Disease
- Pediatric health and respiratory diseases
- Diet, Metabolism, and Disease
- Eicosanoids and Hypertension Pharmacology
- Nutrition, Genetics, and Disease
- Carcinogens and Genotoxicity Assessment
- IL-33, ST2, and ILC Pathways
- RNA modifications and cancer
- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- DNA Repair Mechanisms
- GDF15 and Related Biomarkers
- Forensic and Genetic Research
- Erythrocyte Function and Pathophysiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vitamin D Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Neurological Disorders and Treatments
- Biomarkers in Disease Mechanisms
- RNA Research and Splicing
- Pancreatitis Pathology and Treatment
National Research Tomsk State University
2024
Tomsk Polytechnic University
2024
Kursk State Medical University
2007-2021
Kursk State University
2016
Ministry of Health of the Russian Federation
2015
University of Wisconsin–Madison
1992
The present study was designed to investigate whether genetic polymorphisms of the aryl hydrocarbon receptor (AHR) signaling pathway are involved in molecular basis essential hypertension (EH).A total 2160 unrelated Russian individuals comprising 1341 EH patients and 819 healthy controls were recruited into study. Seven common AHR single-nucleotide (SNPs) such as rs2066853, rs2292596, rs2228099, rs1048943, rs762551, rs1056836, rs1800566 genotyped by TaqMan-based allele discrimination...
The present study was designed to test whether common polymorphism G-50T within the promoter of human CYP2J2 gene is associated with increased risk essential hypertension in a Russian population. We studied 576 unrelated subjects, including 295 patients and 281 healthy subjects. Genotyping for performed by polymerase chain reaction restriction fragment length techniques. frequency -50T variant allele significantly higher versus controls (OR 4.03 95%CI 1.80-9.04 p=0.0004). association -50GT...
Gene encoding flavin-containing monooxygenase 3 (FMO3), a microsomal antioxidant defense enzyme, has been suggested to contribute essential hypertension (EH). The present study was designed investigate whether common functional polymorphism E158K (rs2266782) of the FMO3 gene is associated with EH susceptibility in Russian population. A total 2 995 unrelated subjects from Kursk (1 362 patients and 843 healthy controls) Belgorod (357 422 population regions Central Russia were recruited for...
Numerous studies demonstrated an importance of cytochrome P-450 epoxygenase pathway arachidonic acids metabolism for the pathogenesis essential hypertension (EH). The present study was designed to investigate whether common single-nucleotide polymorphisms (SNP) CYP2C gene subfamily such as CYP2C8 (rs7909236 and rs1934953), CYP2C9 (rs9332242), CYP2C19 (rs4244285) are associated with susceptibility EH in Russian population. A total 816 unrelated individuals comprising 425 patients 391...
Although oxidative stress is a cardinal feature of bronchial asthma, the role interactions between environmental oxidant/antioxidant exposures and antioxidant genes in asthma aetiology has yet to be determined. The present study was conducted investigate whether two common polymorphisms -21A > T -262C catalase (CAT) gene are associated with susceptibility Russian population test hypothesis that risk attributed CAT genotypes could dependent on both oxidant (tobacco smoking) (fruit vegetable...
The present study was designed to investigate whether the susceptibility acute pancreatitis (AP) attributable polymorphism rs10273639 at PRSS1-PRSS2 locus is dependent on alcohol consumption and cigarette smoking.A total of 603 unrelated Russian individuals including 304 patients with physician-diagnosed AP 299 sex- age-matched healthy controls have been recruited for study. A (-408C>T) genotyped by TaqMan-based assay.A variant allele -408T (P = 0.003) genotypes -408CT plus TT 0.002) were...
Background Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify genes that interact with ever smoking in adult onset asthma. Methods We performed a genome-wide interaction analysis six participating GABRIEL consortium following two meta-analyses approaches based on 1) overall effect and 2) subjects exposure. discovery meta-analysis including 4,057 European...
Oxidative stress resulting from an increased amount of reactive oxygen species and imbalance between oxidants antioxidants plays important role in the pathogenesis asthma. The present study tested hypothesis that genetic susceptibility to allergic nonallergic variants asthma is determined by complex interactions genes encoding antioxidant defense enzymes (ADE). We carried out a comprehensive analysis associations adult 46 single nucleotide polymorphisms 34 ADE 12 other candidate Russian...
Objective: The study was designed to assess the effects of polymorphisms in genes associated with essential hypertension on variation erythrocyte membrane proteins (EMPs) hypertensive patients. Methods: Major EMPs content analyzed blood from 1162 unrelated Russians (235 patients, 176 healthy controls, and 751 random individuals Central Russia population). Essential patients were genotyped for 11 susceptibility including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744),...
Transforming growth factor-beta1 (TGF-beta1) has been shown to be an important cytokine that plays a role in cell proliferation, differentiation, tissue injury repair and ulcer healing. The purpose of this pilot study was investigate if common polymorphisms Leu10Pro, Arg25Pro C-509T within the TGF-beta1 gene are associated with susceptibility gastric duodenal disease Russians.Blood samples from 377 unrelated patients 226 sex- age-matched healthy controls were used determine by polymerase...
Background: It has been hypothesized that, whereas many loci are used to generate phylogenetic relationships, the utilization of those that yield most information could increase accuracy any multilocus reconstruction. Among these is D1S80 hypervariable minisatellite region, which shown be highly polymorphic globally, and it was interest compare nearest neighbours distant populations Eastern Europe using polymorphism.Aim: The study evaluated capacity locus discriminate between from different...