A5050550730- Epigenetics and DNA Methylation
- Tissue Engineering and Regenerative Medicine
- Cancer Research and Treatments
- RNA modifications and cancer
- Theoretical and Computational Physics
- Image Processing Techniques and Applications
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Circadian rhythm and melatonin
- S100 Proteins and Annexins
- Advanced Image Processing Techniques
- Inflammasome and immune disorders
- Cancer-related Molecular Pathways
- Signaling Pathways in Disease
- Wound Healing and Treatments
- Bladder and Urothelial Cancer Treatments
- Image and Signal Denoising Methods
- Magneto-Optical Properties and Applications
- Virus-based gene therapy research
- Magnetic properties of thin films
- NF-κB Signaling Pathways
Army Medical University
2024-2025
Nanjing Medical University
2022
Nanjing University
2011-2022
Nanjing General Hospital of Nanjing Military Command
2022
Collaborative Innovation Center of Advanced Microstructures
2021
Model Animal Research Center
2015
Circadian oscillation and cell cycle progression are the two most essential rhythmic events present in almost all organisms. rhythms keep track of time provide temporal regulation with a period about 24 h. The is optimized for growth division, but not keeping. gated divisions observed nearly However, implications this coupling to physiology mammals unknown. A mutation (S662G) clock protein PERIOD2 (PER2) responsible familial advanced sleep phase syndrome which onset occurs early evening...
The persistent accumulation of senescence cells is one the characteristics radiation-induced skin injury (RISI), leading to fibrosis and impaired healing. However, reasons why these are resistant clearance remain unclear. mouse RISI model was established using an X-ray generator, a shield used cover all areas except right leg or back for protecting surrounding tissue. ScRNA sequencing, immunohistochemistry, immunofluorescence, qPCR, western blot, primary cell co-culture system fluorescence...
The cell cycle is a highly regulated process in which proteins involved progression exhibit periodic expression patterns, controlled by specific mechanisms such as transcription, translation, and degradation. However, the precise underlying oscillations of mRNA levels regulators are not fully understood. In this study, we observed that stability cyclin D1 (CCND1) fluctuates during cycle, with increased interphase decreased M phase. Additionally, identified key RNA binding protein, positive...
Abstract p53 is an important tumor suppressor and stress response mediator. Proper control of level activity tightly associated with its function. Posttranslational modifications the interactions Mdm2 Mdm4 are major mechanisms controlling stability. As protein short-lived hardly detectable in unstressed situations, less known on basal expression corresponding vivo . In addition, it also remains obscure how might contribute to functional regulation. this study, we established bacterial...
We report the observation of unidirectional spin Hall magnetoresistance (USMR), which depends on current or magnetization direction, in heavy-metal-ferromagnetic-insulator bilayer, Pt-Y_{3}Fe_{5}O_{12} (YIG). This USMR is apparently not caused by mechanisms established metallic ferromagnetic layer required to be electrically conductive. From magnetic field, current, temperature, and YIG thickness dependent measurements, attributed asymmetric magnon creation annihilation induced spin-orbit...
To propose a multi-modality-based super-resolution synthesis model for reconstruction of routine brain magnetic resonance images (MRI) with low resolution and high thickness into high-resolution images.Based on real paired low-high MRI data (2D T1, 2D T2 FLAIR 3D T1), structure-constrained image mapping network was used to extract important features from the different modalities including whole T1 subcortical regions reconstruct higher resolutions. The gray scale intensity structural...