A5042586778- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Photocatalysis Techniques
- Nanomaterials for catalytic reactions
- Synthesis of Indole Derivatives
- Covalent Organic Framework Applications
- Mesoporous Materials and Catalysis
- Chemical Synthesis and Reactions
- X-ray Diffraction in Crystallography
- Asymmetric Hydrogenation and Catalysis
- Fluorine in Organic Chemistry
- Biosensors and Analytical Detection
- Oxidative Organic Chemistry Reactions
- Crystallization and Solubility Studies
- Microfluidic and Capillary Electrophoresis Applications
- Caching and Content Delivery
- Perovskite Materials and Applications
- Conducting polymers and applications
- Synthesis and Catalytic Reactions
- Diatoms and Algae Research
- Catalytic Cross-Coupling Reactions
National University of Singapore
2023-2024
Peking University
2020-2022
Beijing National Laboratory for Molecular Sciences
2022
Despite remarkable progress in photocatalytic hydrogen atom transfer (HAT)-induced C(sp3)–H functionalization, achieving to C(sp3)–P transformation by the HAT process remains highly challenging due P-reagents' compatibility issues. α-Aminophosphonic acids have shown great potential medicinal chemistry, yet their synthesis is hindered limited substrate scopes, poor functional group tolerance, and reliance on prefunctionalized substrates, restricting broad applications. Herein, we report...
Although continuous flow synthesis using microtubing reactors has provided a wealth of opportunities for homogeneous photochemical and proven particularly beneficial in scaling up processes, employing technology to scale heterogeneous photoreactions is challenging due the issues including handling solids, poor light penetration, commonly lengthy reaction time. Here we present solution these by changing mode high-speed circulation mode. The high rate set reactor overcomes solid sedimentation...
Abstract Efficient methods for synthesizing 1,2‐aryl(alkenyl) heteroatomic cores, encompassing heteroatoms such as nitrogen, oxygen, sulfur, and halogens, are of significant importance in medicinal chemistry pharmaceutical research. In this study, we present a mild, versatile practical photoredox/iron dual catalytic system that enables access to highly privileged pharmacophores with exceptional efficiency site selectivity. Our approach exhibits an extensive scope, allowing the direct...
Acridinium perchlorates and tetrafluoroborates are commonly employed photocatalysts with similar photophysical characteristics. Nevertheless, perchlorate salts consistently exhibit superior catalytic performance relative to their tetrafluoroborate counterparts. In a serendipitous discovery, we unveiled the latent potential of trace chloride anions originating from acridinium salts. When coupled redox mediators like diphenyl ether or biphenyl, displayed remarkable hydrogen atom transfer (HAT)...
Continuous flow synthesis is a widely used method for synthesizing fine chemicals due to its benefits such as process intensification, improved reproducibility, and the ability perform otherwise impossible transformations. Multistep continuous (MCFS) simplifies of complex molecules by telescoping multiple steps into streamlined potentially automated process, reducing human efforts time. Despite these advantages, challenges solid formation, solvent reagent incompatibilities, intermediate...
Efficient methods for synthesizing 1,2-aryl(alkenyl) heteroatomic cores, encompassing heteroatoms such as nitrogen, oxygen, sulfur, and halogens, are of significant importance in medicinal chemistry pharmaceutical research. In this study, we present a mild, versatile practical photoredox/iron dual catalytic system that enables access to highly privileged pharmacophores with exceptional efficiency site selectivity. Our approach exhibits an extensive scope, allowing the direct utilization wide...
Abstract Although continuous-flow synthesis using microtubing reactors has provided a wealth of opportunities for photochemical and proven particularly beneficial in scaling up processes, handling solids slow reactions remains major hurdles that have hampered its broad application. Here, we present solution to these issues by changing the mode high-speed circulation-flow mode. The high flow rate set circulation microflow reactor overcomes solid sedimentation prevent clogging improve mixing...
Despite remarkable progress in photocatalytic hydrogen atom transfer (HAT)-induced C(sp3)-H functionalization, achieving to C(sp3)-P transformation by the HAT process remains highly challenging due P-reagents’ compatibility issues. α-Aminophosphonic acids have shown great potential medicinal chemistry, yet their synthesis is hindered limited substrate scopes, poor functional group tolerance, and reliance on pre-functionalized substrates, restricting broad applications. Herein, we report a...
Abstract Efficient methods for synthesizing 1,2‐aryl(alkenyl) heteroatomic cores, encompassing heteroatoms such as nitrogen, oxygen, sulfur, and halogens, are of significant importance in medicinal chemistry pharmaceutical research. In this study, we present a mild, versatile practical photoredox/iron dual catalytic system that enables access to highly privileged pharmacophores with exceptional efficiency site selectivity. Our approach exhibits an extensive scope, allowing the direct...
Molecular machines have attracted significant attentions as one of the most promising aspects chemistry for their potential applications ever since receiving 2016 Nobel Prize in Chemistry.The molecular assembler, also called nanofactory, is a novel type that are capable controlling chemical reactions precisely at microscopic level.As an analog to macroscopic factories, nanofactories comprised "transporting" part, walkers, and "assembling" robotic arms.In this review, we provide brief...
Organic conjugated polymers with long-range conjugation generally have strong light absorption capacity in the visible region and impressive performance charge transfer, which endows them great application potential field of opto-electronic materials. However, there are few reports on their use photocatalytic reactions. At present, it has been reported that a variety donor-acceptor (D-A) type organic dyes can be used efficient transformations. We designed synthesized one-dimensional...