A5102919573- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Bone Tumor Diagnosis and Treatments
- Sleep and related disorders
- Neuroscience and Neuropharmacology Research
- Oral and Maxillofacial Pathology
- Sarcoma Diagnosis and Treatment
- Microwave and Dielectric Measurement Techniques
- Cardiac Fibrosis and Remodeling
- Neurological disorders and treatments
- Case Reports on Hematomas
- Moyamoya disease diagnosis and treatment
- Telecommunications and Broadcasting Technologies
- Aortic aneurysm repair treatments
- Optical Systems and Laser Technology
- Image Processing Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Wireless Sensor Networks and IoT
- Pain Mechanisms and Treatments
- Optical Imaging and Spectroscopy Techniques
- Exercise and Physiological Responses
Shantou University
2024-2025
First Affiliated Hospital of Shantou University Medical College
2024-2025
Shantou University Medical College
2024
Fudan University
2021-2024
State Key Laboratory of Medical Neurobiology
2021-2024
Xuzhou Medical College
2018-2020
The First Affiliated Hospital, Sun Yat-sen University
2006-2019
Sun Yat-sen University
2006-2019
Peking University Shenzhen Hospital
2018-2019
Shanghai Medical College of Fudan University
2019
Sleep disorders are prevalent among stroke survivors and impede recovery, yet they still insufficiently considered in the management of patients, mechanisms by which occur remain unclear. There is evidence that boosting phasic GABA signaling with zolpidem during repair phase improves recovery enhancing neural plasticity; however, as a non-benzodiazepine hypnotic, effects on post-stroke sleep
The aberrant deposition of β-amyloid (Aβ) is closely linked to the pathogenesis and development Alzheimer's disease (AD). MiR-16 was abnormally downregulated may be related AD. However, functional role molecular mechanism miR-16 in AD are still not well elucidated. expressions β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) mRNA protein levels brain tissues Aβ-treated PC12 cellular model were examined by qRT-PCR western blot analyses. Luciferase reporter assay used verify...
Evidence in animals suggests that deep brain stimulation or optogenetics can be used for recovery from disorders of consciousness (DOC). However, these treatments require invasive procedures. This report presents a noninvasive strategy to stimulate central nervous system neurons selectively DOC mice. Through the delivery ultrasound energy ventral tegmental area, mice were aroused an unconscious, anaesthetized state this study, and process was controlled by adjusting parameters. The sham...
Glucocorticoids are the only therapy that has been demonstrated to alter progress of Duchenne muscular dystrophy (DMD), most common in children. However, glucocorticoids disturb skeletal muscle metabolism and hamper myogenesis regeneration. The mechanisms involved glucocorticoid-mediated suppression myogenic differentiation not fully understood. Glycogen synthase kinase-3β (GSK-3β) is considered play a central role as negative regulator differentiation. Here, we showed glucocorticoid...
Objective Ultimate frisbee can lead to severe sports injuries, especially joint injuries in the lower limbs, such as knee meniscus injuries. This study examines impact of personalized exercise therapy on ultimate players Lingnan region China. Methods Seventy-six patients with confirmed meniscal participated study, divided into an intervention group ( n = 38) and a control 38). The received standard treatment, including drug physical therapy. treatment plus regimen based FITT-VP (frequency,...
Giant cell tumor (GCT) of the bone is a benign but locally aggressive neoplasm with strong tendency to develop local recurrent and metastatic disease. Thus, it provides useful model system for identification biological mechanisms involved in progression metastasis. This study profiled 24 cases versus primary GCT tissues using QuantiGene 2.0 Multiplex Arrays that included Human p53 80-Plex Panels Stem Cell Panels. A total 32 differentially expressed genes were identified, including 20 most...
The Slo3 potassium (KCa 5.1) channel, which is specifically expressed in the testis and sperm, essential for mammalian male fertilization. sequence divergence of bovine, mouse human α-subunit revealed a rapid evolution rate across different species. rat (rSlo3) channel has not been cloned characterized previously.We used molecular cloning, electrophysiology (inside-out patches outside-out patches) mutagenesis to investigate biophysical properties pharmacological characteristics rSlo3...
Background . In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription (STAT1), Rac family small GTPase (RAC1) were correlated with the recurrence giant cell tumor bone (GCT). The aim this study is to use a large cohort confirm involvement these four genes in GCT recurrence. Methods expression was detected compared between patients or without correlation clinical characteristics evaluated....
Abstract Background Sleep disorders are highly prevalent among stroke survivors and impede recovery. It is well established that melatonin has neuroprotective effects in animal models of ischemic stroke. However, as a modulator endogenous physiological circadian rhythms, the on poststroke sleep remain unclear. In present study, we investigated how delivered intraperitoneally once daily subacute phase after onset, influencing neuronal survival, motor recovery, sleep–wake profiles rats....
Inhibition of microRNA-205 is considered to be a therapeutic target for abdominal aortic aneurysm in animal model. Hepatocyte growth factor also plays pivotal roles the pathogenesis intracranial aneurysms, and its expression can regulated by different miRNAs processes. We investigated involvement aneurysms explored potential interaction with hepatocyte factor. found that blood levels were significantly higher patients than healthy controls. High showed diagnostic values aneurysms....
The internal structural details of unknown structures are very helpful to our personnel in carrying out activities during anti-terrorism operations and emergency disaster relief urban environments.According multipath identification propagation mechanism separation technology, a building structure perspective imaging algorithm based on the ray-tracing model is proposed this paper by making full use rich delay power spectrum information gradually filtering multipath.Based results taking...
The aim of this study is to accurately extract the dielectric parameters building materials through nondestructive measurement methods. ultrawideband (UWB) system used capture echoes from marble targets in frequency range 2.5–15 GHz, and reflection coefficient derived using a time window separation technique. By combining particle swarm optimization (PSO) algorithm, are successfully inverted. Research results show that relative constant extracted under three different incident angle...
Articular cartilage degeneration may lead to osteoarthritis (OA) during the aging process, but its underlying mechanism remains unknown. Here, we found that chondrocytes exhibited an energy metabolism shift from glycolysis oxidative phosphorylation (OXPHOS) aging. Parkin regulates various cellular metabolic processes. Reprogrammed by ablation decreased OXPHOS and increased glycolysis, with ameliorated aging-related OA. Metabolomics analysis indicated lauroyl-L-carnitine (LLC) was in aged...
Objective To investigate the potential differences in efficacy of anterior and posterior cruciate ligaments(ACL & PCL) reconstruction by using arthroscopy between autologous tendon allograft. Methods A total 144 patients with ACL or PCL fracture were assigned into two groups, namely tibial muscle tendons allograft(n=82) autograft(n=63). The graft was fixed Endobutton Intrafix systems.The general information, drawer test, Lachman IKDC score, Lysholm score Tegner compared groups before...
Objective To investigate the clinical efficacy of atlantoaxial pedicle screw fixation plus bony fusion in treatment traumatic upper cervical instability. Methods From October 2009 to August 2013, 29 patients with spine instability were treated posterior screws. The underwent autografting (n=19) and allografting (n=10) for spinal fusion. Surgical outcomes recorded including intraoperative blood loss, operation time, or without nerve, vessel cord injury, wound healing bone...