A5090126632- Plasma Applications and Diagnostics
- Electrohydrodynamics and Fluid Dynamics
- Heme Oxygenase-1 and Carbon Monoxide
- Plasma and Flow Control in Aerodynamics
- Plasma Diagnostics and Applications
- Aerosol Filtration and Electrostatic Precipitation
- Surface Modification and Superhydrophobicity
- Particle Dynamics in Fluid Flows
- Autophagy in Disease and Therapy
- Redox biology and oxidative stress
- Combustion and flame dynamics
Institute of Chemical Biology and Fundamental Medicine
2021-2023
Novosibirsk State University
2022-2023
Siberian Branch of the Russian Academy of Sciences
2023
Cold atmospheric plasma (CAP) is an intensively-studied approach for the treatment of malignant neoplasms. Various active oxygen and nitrogen compounds are believed to be main cytotoxic effectors on biotargets; however, comprehensive mechanism CAP interaction with living cells tissues remains elusive. In this study, we experimentally determined optimal discharge regime (or semi-selective regime) direct jet cancer cells, under which lung adenocarcinoma A549, A427 NCI-H23 demonstrated...
Abstract The effect of the presence or absence a grounded substrate beneath dielectric targets, including cancer cells, during exposure to cold atmospheric plasma jet is studied in experiments and fluid model simulations for discharge parameters typical medical applications. It shown that dynamics streamers generated each positive cycle ac voltage depends on position. approach target more often if target, provides intensive plasma-target interaction. In this case, measured spectrum emission...
Abstract Low-temperature plasma jets at atmospheric pressure generated by sinusoidal and positive pulsed voltages interact differently with the treated surface. In experiment in numerical simulations, we compare operating modes of helium for these types voltages. The discharge current on surface over time heating are studied different parameters acceptable anticancer therapy. intensity emission spectrum is analyzed to improve effectiveness jet. Surface controlled order meet safety conditions...
The interaction of cold atmospheric plasma (CAP) with biotargets is accompanied by chemical reactions on their surfaces and insides, it has great potential as an anticancer approach. This study discovers the molecular mechanisms that may explain selective death tumor cells under CAP exposure. To reach this goal, transcriptional response to treatment was analyzed in A549 lung adenocarcinoma lung-fibroblast Wi-38 cells. We found induced common trend from cells—the p53 pathway, KRAS signaling,...
Abstract Cold atmospheric plasma (CAP) jet generated by the source at 2-6 kV ac voltages with frequencies of 10-50 kHz demonstrate different modes operation. Depending on voltage frequency and amplitude, some streamers in are short decay before they approach treated surface. In this case, effect viability cancer cells when exposed to CAP strongly depends mode operation discharge or, other words, how many times hit bio-target during treatment. The A549 is reported.