A5007997301- RNA Research and Splicing
- Extracellular vesicles in disease
- Nuclear Structure and Function
- RNA and protein synthesis mechanisms
- Heat shock proteins research
- Molecular Biology Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Cancer Immunotherapy and Biomarkers
- RNA regulation and disease
- Psoriasis: Treatment and Pathogenesis
- Fuel Cells and Related Materials
- Cancer Cells and Metastasis
- Cardiomyopathy and Myosin Studies
- Polyomavirus and related diseases
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Plant Virus Research Studies
- Cancer Genomics and Diagnostics
- thermodynamics and calorimetric analyses
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
Inserm
2019-2023
La Ligue Contre le Cancer
2019-2023
Université de Lorraine
2015-2021
Centre Georges François Leclerc
2019-2021
Université de Bourgogne
2019-2021
Université Bourgogne Franche-Comté
2019-2021
Ingénierie Moléculaire et Physiopathologie Articulaire
2013-2021
Centre National de la Recherche Scientifique
2015-2021
Centre de recherche Translationnelle en Médecine moléculaire
2019
Molina Center for Energy and the Environment
2015
Abstract Background Circulating tumour cells (CTCs), circulating DNA (ctDNA), and extracellular vesicles (EVs) are minimally invasive liquid biopsy biomarkers. This study investigated whether they predict prognosis, alone or in combination, heterogenous unbiased non-small cell lung cancer (NSCLC) patients. Methods Plasma samples of 54 advanced NSCLC patients from a prospective clinical trial. CtDNA mutations were identified using the UltraSEEK™ Lung Panel (MassARRAY® technology). PD-L1...
Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder phenotypically characterized by many features of premature aging. Most cases HGPS are due to heterozygous silent mutation (c.1824C>T; p.Gly608Gly) that enhances the use an internal 5′ splice site (5′SS) in exon 11 LMNA pre-mRNA and leads production truncated protein (progerin) with dominant negative effect. Here we show changes accessibility 5′SS which sequestered conserved RNA structure. Our results also reveal...
Exosomes are involved in modulating the immune system and mediating communication between cells. The aim of this study was to investigate involvement exosomes psoriasis. from patients with psoriasis were analysed by nanoparticle tracking analysis protein expression western blotting. concentration HSP70 determined an enzyme-linked immunosorbent assay, concentrations interleukin (IL)-1?, IL-2, IL-6, IL-10, IL-17A tumour necrosis factor alpha (TNF-?) flow cytometry. Based on severity psoriasis,...
Abstract Exosomes, as potential circulated biomarkers, have recently become a topic of interest in the field oncology. Immune checkpoint molecule PD‐L1 has been detected circulating exosomes from cancer patients. The purpose this work was to evaluate levels (Exo‐PD‐L1) isolated patients’ plasma suffering Merkel cell carcinoma (MCC). We conducted prospective bicentric cohort study. analysed samples patients MCC stage I IV (according AJCC 8). Exosomes 34 corresponding 66 were analysed....
The Hutchinson Gilford Progeria Syndrome (HGPS) is a rare genetic disease leading to accelerated aging. Three mutations of the LMNA gene HGPS were identified. more frequent ones, c.1824C>T and c.1822G>A, enhance use intron 11 progerin 5'splice site (5'SS) instead 5'SS, production truncated dominant negative progerin. less c.1868C>G mutation creates novel 5'SS (LAΔ35 5'SS), inducing another protein (LAΔ35). Our data show that used at low yield in absence mutation, whereas utilization LAΔ35...
<sec> <title>UNSTRUCTURED</title> Background: Sarcomas are rare cancer with heterogeneous group of tumours. Metastasis is often fatal, and current prognostic methods limited. Recent findings show that sarcoma cells release small extracellular vesicles. Studying them can help assess development, progression, treatment effectiveness. This study aims to demonstrate the potential vesicles for monitoring disease predicting recurrence risk. Methods: A multicentric, prospective pilot will include...