A5018330264- Neonatal Health and Biochemistry
- Retinopathy of Prematurity Studies
- Iron Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Neonatal Respiratory Health Research
- Hemoglobinopathies and Related Disorders
- Hemophilia Treatment and Research
- Intraocular Surgery and Lenses
- Blood transfusion and management
- Acute Lymphoblastic Leukemia research
- Liver Disease and Transplantation
- Bone and Joint Diseases
- Childhood Cancer Survivors' Quality of Life
- Anesthesia and Neurotoxicity Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism and Genetic Disorders
- Hematological disorders and diagnostics
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Cardiac Arrest and Resuscitation
Children's Hospital of Eastern Ontario
2021-2024
University of Ottawa
2021-2023
NOSM University
2018-2019
University of Toronto
2018
Background: Asparaginases are a mainstay treatment for pediatric acute lymphoblastic leukemia (ALL). Recent reports identified hypoglycemia associated with asparaginases. Other describe 6-mercaptopurine (6-MP), another fundamental ALL therapy. Little is known about the risk of therapy, an adverse event that puts children at decreased level consciousness, seizures, and possibly negative neurocognitive sequelae. Methods: We performed retrospective chart review 6 during in our institution from...
Although screening examinations for retinopathy of prematurity (ROP) prevent blindness, they are physiologically stressful infants. Photosensitivity during mydriasis may contribute to postexamination stress, and reducing light stimulation make infants more comfortable.To determine the effect a phototherapy mask worn on infant stress in 12-hour period following ROP screening.The Effect Eyemasks Neonatal Stress Following Dilated Retinal Examination (MASK-ROP) randomized clinical trial with...
Transfusion is discouraged in hemodynamically stable children with severe iron deficiency anemia (IDA). Intravenous (IV) sucrose (IS) could be an alternative for some patients; however, there a paucity of data on its use the paediatric emergency department (ED).We analyzed patients presenting IDA at Children's Hospital Eastern Ontario (CHEO) ED between September 1, 2017, and June 2021. We defined as microcytic <70 g/L either ferritin <12 ng/mL or documented clinical diagnosis.Of 57 patients,...
Background: In adults with medically refractory sinusoidal obstruction syndrome (SOS), a transjugular intrahepatic portosystemic shunt (TIPS) has been used successfully to improve portal hypertension and symptoms such as ascites. There is limited data on the use of TIPS for SOS in pediatric patients. Methods: The index case was reviewed retrospectively. PubMed Medline databases were searched identify other cases. Results: A 4-year-old male high-risk neuroblastoma, developed after tandem...
Paediatric patients with acute myeloid leukaemia (AML) often present symptoms associated the disruption of normal haematopoiesis and subsequent cellular deficiencies. Periosteal reactions are common in paediatric leukaemia, but typically manifest as a thin, laminated pattern along long bones. Aggressive periosteal much less frequently seen. Here, we report case AML initially presenting proptosis periorbital swelling caused by aggressive, sunburst surrounding sphenoid zygomatic This unique...
Abstract Background Paediatric iron deficiency anemia (IDA) is a common condition in Canadian children; however, little known about the natural history of extreme cases. This deficit makes it challenging to determine how approach management when these patients present acutely emergency department (ED). Objectives To describe clinical features and children presenting ED with very severe IDA hemoglobin &lt; 40 g/L. Design/Methods Retrospective chart reviews were performed for paediatric...
Background: Retinopathy of prematurity (ROP) is a disorder retinal development in the low birthweight preterm infant. Eye screening routinely performed for infants at risk developing this disorder. While these examinations help prevent blindness, they can be physiologically stressful infants, with changes oxygen saturation, blood pressure and heart rate occurring during exam increased apneic episodes reported 24–48 hours period afterward. The cause not currently known. Our Background to...
Abstract BACKGROUND Retinopathy of prematurity (ROP) is a disorder retinal development in the low birthweight preterm infant. Eye screening routinely performed for infants at risk developing this disorder. While these examinations help prevent blindness, they can be physiologically stressful infants, with changes oxygen saturation, blood pressure and heart rate occurring during exam increased apneic episodes reported 24–48 hours period afterward. The cause not currently known. OBJECTIVES To...